Single cell type - LPAR6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LPAR6
Gene descriptionⁱ Full gene name according to HGNC.	Lysophosphatidic acid receptor 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes G-protein coupled receptors Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Langerhans cells, Early spermatids, Basal squamous epithelial cells, Late spermatids, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AF22, HUVEC TERT2, MOLT-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Langerhans cells, Early spermatids, Basal squamous epithelial cells, Late spermatids, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LPAR6 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HCAR2	Hydroxycarboxylic acid receptor 2	0.5485	61
INPP1	Inositol polyphosphate-1-phosphatase	0.5419	34
SOX7	SRY-box transcription factor 7	0.5411	14
THBD	Thrombomodulin	0.5361	41
FCGR2A	Fc fragment of IgG receptor IIa	0.5316	4
FUT1	Fucosyltransferase 1 (H blood group)	0.5266	14
CYYR1	Cysteine and tyrosine rich 1	0.5245	14
HLA-DQB2	Major histocompatibility complex, class II, DQ beta 2	0.5243	41
FPR3	Formyl peptide receptor 3	0.5235	4
NFKBIA	NFKB inhibitor alpha	0.5196	41
AHR	Aryl hydrocarbon receptor	0.5065	41
CD1E	CD1e molecule	0.5032	41
CD1B	CD1b molecule	0.5006	41
KRT33A	Keratin 33A	0.4956	61
TIFAB	TIFA inhibitor	0.4943	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	9.7 nTPM
Lung	9.7 nTPM

Astrocytes	4.9 nTPM
Brain	4.9 nTPM

B-cells	5.8 nTPM
Kidney	14.3 nTPM
Colon	12.8 nTPM
Breast	9.4 nTPM
Liver	7.2 nTPM
Adipose tissue	5.0 nTPM
PBMC	4.3 nTPM
Lymph node	1.9 nTPM
Spleen	1.4 nTPM
Stomach	0.9 nTPM
Bone marrow	0.8 nTPM

Basal keratinocytes	120.6 nTPM
Skin	120.6 nTPM

Adipocytes	266.1 nTPM
Breast	325.0 nTPM
Adipose tissue	207.2 nTPM

Basal squamous epithelial cells	327.2 nTPM
Esophagus	327.2 nTPM

Dendritic cells	22.2 nTPM
Adipose tissue	34.1 nTPM
Breast	32.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	140.1 nTPM
Breast	299.8 nTPM
Heart muscle	218.8 nTPM
Esophagus	216.8 nTPM
Skin	205.9 nTPM
Skeletal muscle	199.7 nTPM
Placenta	192.1 nTPM
Prostate	119.2 nTPM
Endometrium	110.0 nTPM
Eye	108.4 nTPM
Testis	89.2 nTPM
Ovary	78.3 nTPM
Lung	56.1 nTPM
Liver	51.3 nTPM
Pancreas	15.5 nTPM

Fibroblasts	23.6 nTPM
Skin	51.0 nTPM
Stomach	34.1 nTPM
Prostate	33.8 nTPM
Breast	27.8 nTPM
Esophagus	24.4 nTPM
Adipose tissue	20.6 nTPM
Heart muscle	19.2 nTPM
Lung	15.7 nTPM
Skeletal muscle	13.1 nTPM
Ovary	11.0 nTPM
Placenta	8.9 nTPM

Intestinal goblet cells	4.9 nTPM
Rectum	7.1 nTPM
Small intestine	3.8 nTPM
Colon	3.6 nTPM

Macrophages	111.9 nTPM
Testis	322.4 nTPM
Prostate	288.8 nTPM
Esophagus	240.8 nTPM
Adipose tissue	116.0 nTPM
Kidney	109.6 nTPM
Breast	107.2 nTPM
Bone marrow	88.7 nTPM
Endometrium	82.0 nTPM
Lung	77.8 nTPM
Ovary	64.9 nTPM
Skeletal muscle	57.8 nTPM
Stomach	46.9 nTPM
Spleen	39.4 nTPM
Pancreas	35.7 nTPM
PBMC	0.0 nTPM

Paneth cells	4.1 nTPM
Rectum	12.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	6.3 nTPM
Adipose tissue	21.3 nTPM
Esophagus	6.1 nTPM
Spleen	2.3 nTPM
Bone marrow	1.7 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	49.4 nTPM
Bronchus	63.8 nTPM
Lung	35.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Endometrial stromal cells	20.7 nTPM
Endometrium	20.7 nTPM

Excitatory neurons	1.8 nTPM
Brain	1.8 nTPM

Smooth muscle cells	13.3 nTPM
Bronchus	30.5 nTPM
Skin	27.6 nTPM
Heart muscle	17.2 nTPM
Prostate	16.6 nTPM
Breast	14.4 nTPM
Endometrium	13.7 nTPM
Ovary	10.5 nTPM
Skeletal muscle	8.2 nTPM
Adipose tissue	3.9 nTPM
Pancreas	2.7 nTPM
Esophagus	1.5 nTPM

T-cells	52.3 nTPM
Skin	309.4 nTPM
Kidney	87.6 nTPM
Liver	66.3 nTPM
Lung	62.3 nTPM
PBMC	60.2 nTPM
Adipose tissue	47.9 nTPM
Spleen	38.6 nTPM
Prostate	33.1 nTPM
Bone marrow	32.8 nTPM
Lymph node	29.3 nTPM
Skeletal muscle	28.3 nTPM
Esophagus	26.2 nTPM
Colon	20.5 nTPM
Breast	15.0 nTPM
Endometrium	13.7 nTPM
Ovary	11.1 nTPM
Stomach	6.7 nTPM

Undifferentiated cells	9.6 nTPM
Colon	12.4 nTPM
Rectum	9.0 nTPM
Small intestine	7.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC