Single cell type - MBNL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MBNL2
Gene descriptionⁱ Full gene name according to HGNC.	Muscleblind like splicing regulator 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MBNL2 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MON2	MON2 homolog, regulator of endosome-to-Golgi trafficking	0.5583	42
PRRG1	Proline rich and Gla domain 1	0.5401	42
PTBP2	Polypyrimidine tract binding protein 2	0.5116	42
GAB1	GRB2 associated binding protein 1	0.4897	42
FUT8	Fucosyltransferase 8	0.4845	42
RAPGEF5	Rap guanine nucleotide exchange factor 5	0.4781	42
DPYD	Dihydropyrimidine dehydrogenase	0.4736	42
OSBPL1A	Oxysterol binding protein like 1A	0.4731	42
ELF2	E74 like ETS transcription factor 2	0.4702	41
ANKRD28	Ankyrin repeat domain 28	0.4677	55
LPAR1	Lysophosphatidic acid receptor 1	0.4667	42
NXPE3	Neurexophilin and PC-esterase domain family member 3	0.4630	42
OTUD7A	OTU deubiquitinase 7A	0.4566	42
FAM13C	Family with sequence similarity 13 member C	0.4556	42
ZFP36	ZFP36 ring finger protein	0.4554	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	153.8 nTPM
Adipose tissue	226.5 nTPM
Breast	81.0 nTPM

Alveolar cells type 1	83.3 nTPM
Lung	83.3 nTPM

Alveolar cells type 2	45.1 nTPM
Lung	45.1 nTPM

Astrocytes	148.9 nTPM
Brain	148.9 nTPM

B-cells	52.3 nTPM
Adipose tissue	100.3 nTPM
Stomach	91.3 nTPM
Spleen	89.3 nTPM
Lymph node	77.8 nTPM
Breast	49.4 nTPM
Bone marrow	43.4 nTPM
Colon	36.7 nTPM
Liver	24.6 nTPM
PBMC	9.9 nTPM
Kidney	0.0 nTPM

Basal squamous epithelial cells	129.1 nTPM
Esophagus	129.1 nTPM

Dendritic cells	31.6 nTPM
Adipose tissue	54.5 nTPM
Breast	20.4 nTPM
PBMC	20.0 nTPM

Endothelial cells	66.6 nTPM
Endometrium	115.7 nTPM
Ovary	103.9 nTPM
Skin	91.4 nTPM
Esophagus	86.4 nTPM
Skeletal muscle	78.9 nTPM
Lung	77.9 nTPM
Heart muscle	75.5 nTPM
Breast	68.7 nTPM
Testis	51.0 nTPM
Eye	46.9 nTPM
Prostate	41.3 nTPM
Placenta	38.0 nTPM
Liver	33.9 nTPM
Pancreas	23.1 nTPM

Fibroblasts	75.7 nTPM
Adipose tissue	175.7 nTPM
Esophagus	110.6 nTPM
Lung	91.6 nTPM
Heart muscle	89.9 nTPM
Stomach	77.2 nTPM
Breast	74.0 nTPM
Skeletal muscle	65.4 nTPM
Skin	51.8 nTPM
Ovary	35.6 nTPM
Placenta	33.6 nTPM
Prostate	26.8 nTPM

Intestinal goblet cells	29.0 nTPM
Rectum	45.6 nTPM
Colon	21.5 nTPM
Small intestine	19.8 nTPM

Macrophages	31.2 nTPM
Adipose tissue	96.7 nTPM
Esophagus	55.1 nTPM
PBMC	40.9 nTPM
Ovary	35.4 nTPM
Skeletal muscle	33.6 nTPM
Spleen	30.0 nTPM
Endometrium	29.4 nTPM
Breast	23.4 nTPM
Testis	21.5 nTPM
Bone marrow	21.2 nTPM
Prostate	20.7 nTPM
Stomach	20.5 nTPM
Lung	18.2 nTPM
Kidney	14.3 nTPM
Pancreas	7.7 nTPM

Paneth cells	14.5 nTPM
Rectum	22.3 nTPM
Small intestine	11.3 nTPM
Colon	9.9 nTPM

Plasma cells	169.1 nTPM
Stomach	263.8 nTPM
Esophagus	246.5 nTPM
Spleen	160.3 nTPM
Adipose tissue	117.4 nTPM
Bone marrow	57.7 nTPM

Respiratory ciliated cells	54.5 nTPM
Lung	86.0 nTPM
Bronchus	22.9 nTPM

Smooth muscle cells	80.8 nTPM
Adipose tissue	181.1 nTPM
Esophagus	138.0 nTPM
Heart muscle	93.4 nTPM
Endometrium	86.4 nTPM
Skeletal muscle	85.0 nTPM
Bronchus	80.8 nTPM
Breast	67.1 nTPM
Prostate	54.4 nTPM
Skin	47.1 nTPM
Ovary	32.0 nTPM
Pancreas	23.3 nTPM

Cholangiocytes	50.1 nTPM
Liver	50.1 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cone photoreceptor cells	47.9 nTPM
Eye	47.9 nTPM

Cytotrophoblasts	25.3 nTPM
Placenta	25.3 nTPM

T-cells	40.8 nTPM
Adipose tissue	99.3 nTPM
Prostate	80.4 nTPM
Spleen	56.8 nTPM
Endometrium	52.3 nTPM
Stomach	47.8 nTPM
Lymph node	46.0 nTPM
Skeletal muscle	44.0 nTPM
Skin	43.7 nTPM
Esophagus	39.3 nTPM
Bone marrow	36.1 nTPM
Breast	29.3 nTPM
Lung	25.8 nTPM
Colon	24.7 nTPM
Liver	21.6 nTPM
PBMC	16.9 nTPM
Kidney	15.8 nTPM
Ovary	13.4 nTPM

Undifferentiated cells	17.9 nTPM
Rectum	25.3 nTPM
Small intestine	17.1 nTPM
Colon	11.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC