Single cell type - JDP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	JDP2
Gene descriptionⁱ Full gene name according to HGNC.	Jun dimerization protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HHSteC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

JDP2 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GAS1	Growth arrest specific 1	0.7988	50
GSC	Goosecoid homeobox	0.7553	50
ACKR3	Atypical chemokine receptor 3	0.7525	50
WNT11	Wnt family member 11	0.7448	50
SPRY2	Sprouty RTK signaling antagonist 2	0.7321	50
MAP1LC3C	Microtubule associated protein 1 light chain 3 gamma	0.7220	50
TNXB	Tenascin XB	0.7204	50
ANGPTL2	Angiopoietin like 2	0.7164	50
GSN	Gelsolin	0.7154	50
EBF3	EBF transcription factor 3	0.7102	50
PDGFRL	Platelet derived growth factor receptor like	0.7099	50
BOC	BOC cell adhesion associated, oncogene regulated	0.7064	50
KRTAP13-4	Keratin associated protein 13-4	0.7009	50
VIT	Vitrin	0.6978	50
CFD	Complement factor D	0.6936	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	33.5 nTPM
Lung	33.5 nTPM

Astrocytes	26.8 nTPM
Brain	26.8 nTPM

B-cells	9.9 nTPM
Breast	24.1 nTPM
Adipose tissue	23.6 nTPM
Bone marrow	10.6 nTPM
Liver	9.2 nTPM
Stomach	7.7 nTPM
PBMC	5.7 nTPM
Spleen	5.5 nTPM
Kidney	4.8 nTPM
Lymph node	4.6 nTPM
Colon	3.2 nTPM

Basal keratinocytes	16.4 nTPM
Skin	16.4 nTPM

Dendritic cells	1.2 nTPM
Breast	1.8 nTPM
Adipose tissue	1.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	21.2 nTPM
Eye	66.3 nTPM
Skeletal muscle	35.7 nTPM
Ovary	32.1 nTPM
Endometrium	26.1 nTPM
Breast	23.6 nTPM
Skin	23.3 nTPM
Heart muscle	17.5 nTPM
Prostate	16.7 nTPM
Liver	15.6 nTPM
Lung	9.3 nTPM
Esophagus	9.3 nTPM
Pancreas	7.7 nTPM
Testis	7.1 nTPM
Placenta	5.7 nTPM

Fibroblasts	49.5 nTPM
Adipose tissue	200.6 nTPM
Skeletal muscle	94.8 nTPM
Breast	67.1 nTPM
Skin	41.0 nTPM
Heart muscle	31.0 nTPM
Esophagus	27.8 nTPM
Ovary	22.7 nTPM
Placenta	19.8 nTPM
Stomach	17.8 nTPM
Lung	13.4 nTPM
Prostate	8.4 nTPM

Intestinal goblet cells	14.9 nTPM
Colon	20.8 nTPM
Rectum	14.3 nTPM
Small intestine	9.7 nTPM

Macrophages	47.3 nTPM
Adipose tissue	147.8 nTPM
Breast	106.0 nTPM
Ovary	103.2 nTPM
Skeletal muscle	77.4 nTPM
Esophagus	53.5 nTPM
Stomach	52.7 nTPM
Spleen	39.4 nTPM
Endometrium	28.0 nTPM
Testis	26.7 nTPM
Bone marrow	26.2 nTPM
Prostate	22.9 nTPM
Kidney	12.0 nTPM
Lung	8.6 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	8.2 nTPM
Rectum	10.9 nTPM
Colon	9.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	9.8 nTPM
Adipose tissue	20.6 nTPM
Bone marrow	11.5 nTPM
Esophagus	6.1 nTPM
Spleen	5.6 nTPM
Stomach	4.9 nTPM

Respiratory ciliated cells	7.4 nTPM
Bronchus	7.6 nTPM
Lung	7.3 nTPM

Smooth muscle cells	19.5 nTPM
Adipose tissue	76.5 nTPM
Ovary	33.2 nTPM
Skeletal muscle	18.5 nTPM
Breast	18.5 nTPM
Endometrium	15.9 nTPM
Heart muscle	13.7 nTPM
Esophagus	10.9 nTPM
Pancreas	10.6 nTPM
Prostate	7.8 nTPM
Skin	6.6 nTPM
Bronchus	2.9 nTPM

T-cells	2.2 nTPM
Skin	9.2 nTPM
Endometrium	5.3 nTPM
Skeletal muscle	4.7 nTPM
Adipose tissue	4.7 nTPM
Lung	4.5 nTPM
Breast	4.3 nTPM
Ovary	2.2 nTPM
Liver	1.3 nTPM
PBMC	0.9 nTPM
Stomach	0.3 nTPM
Spleen	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM

Cone photoreceptor cells	10.4 nTPM
Eye	10.4 nTPM

Cytotrophoblasts	1.4 nTPM
Placenta	1.4 nTPM

Endometrial stromal cells	18.4 nTPM
Endometrium	18.4 nTPM

Excitatory neurons	18.9 nTPM
Brain	18.9 nTPM

Undifferentiated cells	8.7 nTPM
Rectum	12.2 nTPM
Colon	8.5 nTPM
Small intestine	5.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC