Single cell type - MFAP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MFAP1
Gene descriptionⁱ Full gene name according to HGNC.	Microfibril associated protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MFAP1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLTA	Clathrin light chain A	0.6320	10
HSPA4	Heat shock protein family A (Hsp70) member 4	0.6098	10
RAB14	RAB14, member RAS oncogene family	0.5898	10
SNX6	Sorting nexin 6	0.5851	10
HNRNPA3	Heterogeneous nuclear ribonucleoprotein A3	0.5792	10
POTEE	POTE ankyrin domain family member E	0.5768	10
RBM42	RNA binding motif protein 42	0.5719	18
MED19	Mediator complex subunit 19	0.5425	10
ANP32D	Acidic nuclear phosphoprotein 32 family member D	0.5399	10
PPIG	Peptidylprolyl isomerase G	0.5333	10
HNRNPR	Heterogeneous nuclear ribonucleoprotein R	0.5315	10
TSG101	Tumor susceptibility 101	0.5221	10
UBAP2L	Ubiquitin associated protein 2 like	0.5151	10
DNAJA2	DnaJ heat shock protein family (Hsp40) member A2	0.5147	10
PITPNA	Phosphatidylinositol transfer protein alpha	0.5129	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.4 nTPM
Breast	37.9 nTPM
Adipose tissue	22.9 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	30.2 nTPM
Lung	30.2 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	32.8 nTPM
Adipose tissue	59.6 nTPM
Lymph node	50.3 nTPM
Colon	41.5 nTPM
PBMC	40.0 nTPM
Breast	32.1 nTPM
Stomach	31.4 nTPM
Liver	28.1 nTPM
Spleen	26.7 nTPM
Kidney	9.5 nTPM
Bone marrow	9.0 nTPM

Dendritic cells	33.2 nTPM
Adipose tissue	45.6 nTPM
Breast	37.9 nTPM
PBMC	16.0 nTPM

Endothelial cells	35.6 nTPM
Lung	65.5 nTPM
Prostate	46.4 nTPM
Placenta	44.4 nTPM
Pancreas	38.6 nTPM
Eye	36.4 nTPM
Esophagus	36.0 nTPM
Endometrium	33.8 nTPM
Skeletal muscle	32.5 nTPM
Testis	32.0 nTPM
Ovary	29.9 nTPM
Breast	29.4 nTPM
Heart muscle	28.7 nTPM
Skin	26.2 nTPM
Liver	19.2 nTPM

Fibroblasts	29.8 nTPM
Heart muscle	50.5 nTPM
Placenta	48.8 nTPM
Ovary	30.0 nTPM
Stomach	29.7 nTPM
Prostate	29.2 nTPM
Esophagus	27.9 nTPM
Breast	27.9 nTPM
Skeletal muscle	25.8 nTPM
Adipose tissue	24.0 nTPM
Lung	17.9 nTPM
Skin	16.7 nTPM

Intestinal goblet cells	24.4 nTPM
Colon	33.6 nTPM
Small intestine	20.1 nTPM
Rectum	19.6 nTPM

Macrophages	25.5 nTPM
Esophagus	42.5 nTPM
Adipose tissue	40.9 nTPM
Lung	40.6 nTPM
Endometrium	33.8 nTPM
Breast	29.7 nTPM
Kidney	29.5 nTPM
Stomach	26.4 nTPM
Testis	25.5 nTPM
Skeletal muscle	24.7 nTPM
Ovary	23.0 nTPM
Prostate	21.8 nTPM
Bone marrow	16.3 nTPM
Spleen	15.6 nTPM
Pancreas	12.8 nTPM
PBMC	0.0 nTPM

Paneth cells	27.1 nTPM
Colon	32.9 nTPM
Small intestine	30.0 nTPM
Rectum	18.4 nTPM

Plasma cells	20.6 nTPM
Spleen	33.1 nTPM
Stomach	19.4 nTPM
Esophagus	18.4 nTPM
Adipose tissue	17.4 nTPM
Bone marrow	14.8 nTPM

Respiratory ciliated cells	60.0 nTPM
Lung	83.1 nTPM
Bronchus	36.9 nTPM

Smooth muscle cells	41.7 nTPM
Bronchus	143.0 nTPM
Endometrium	38.3 nTPM
Pancreas	38.1 nTPM
Ovary	38.0 nTPM
Breast	32.4 nTPM
Adipose tissue	32.1 nTPM
Esophagus	31.0 nTPM
Skeletal muscle	30.6 nTPM
Prostate	29.7 nTPM
Heart muscle	25.9 nTPM
Skin	19.6 nTPM

T-cells	33.6 nTPM
Adipose tissue	62.4 nTPM
Prostate	47.3 nTPM
Lymph node	46.6 nTPM
Breast	45.4 nTPM
Colon	34.7 nTPM
Endometrium	34.0 nTPM
Kidney	32.9 nTPM
Esophagus	32.8 nTPM
Skeletal muscle	32.1 nTPM
PBMC	29.5 nTPM
Spleen	29.0 nTPM
Stomach	28.9 nTPM
Lung	28.8 nTPM
Skin	25.7 nTPM
Liver	24.7 nTPM
Bone marrow	22.6 nTPM
Ovary	13.4 nTPM

Basal keratinocytes	30.3 nTPM
Skin	30.3 nTPM

Basal respiratory cells	50.1 nTPM
Bronchus	50.1 nTPM

Basal squamous epithelial cells	35.9 nTPM
Esophagus	35.9 nTPM

Collecting duct cells	51.5 nTPM
Kidney	51.5 nTPM

Undifferentiated cells	21.3 nTPM
Colon	25.1 nTPM
Rectum	19.7 nTPM
Small intestine	19.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC