Single cell type - MBTPS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MBTPS1
Gene descriptionⁱ Full gene name according to HGNC.	Membrane bound transcription factor peptidase, site 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MBTPS1 is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SAMD7	Sterile alpha motif domain containing 7	0.8028	46
RAX2	Retina and anterior neural fold homeobox 2	0.7992	46
PDE6B	Phosphodiesterase 6B	0.7972	46
EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit	0.7968	46
GUCY2F	Guanylate cyclase 2F, retinal	0.7955	46
CROCC	Ciliary rootlet coiled-coil, rootletin	0.7932	46
PRPH2	Peripherin 2	0.7914	46
CNGB1	Cyclic nucleotide gated channel subunit beta 1	0.7883	46
NR2E3	Nuclear receptor subfamily 2 group E member 3	0.7865	46
SPINT4	Serine peptidase inhibitor, Kunitz type 4	0.7863	46
ZMYND19	Zinc finger MYND-type containing 19	0.7853	46
PDE6A	Phosphodiesterase 6A	0.7853	46
KCNJ14	Potassium inwardly rectifying channel subfamily J member 14	0.7836	46
ZFYVE26	Zinc finger FYVE-type containing 26	0.7836	46
KLHL34	Kelch like family member 34	0.7823	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	54.3 nTPM
Breast	57.6 nTPM
Adipose tissue	51.1 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	50.7 nTPM
Lung	50.7 nTPM

Astrocytes	27.1 nTPM
Brain	27.1 nTPM

B-cells	33.5 nTPM
Liver	47.0 nTPM
Adipose tissue	46.1 nTPM
PBMC	44.2 nTPM
Breast	41.5 nTPM
Lymph node	32.7 nTPM
Stomach	27.3 nTPM
Bone marrow	26.2 nTPM
Kidney	23.8 nTPM
Spleen	23.6 nTPM
Colon	22.3 nTPM

Dendritic cells	41.0 nTPM
Adipose tissue	51.6 nTPM
PBMC	35.8 nTPM
Breast	35.7 nTPM

Endothelial cells	39.8 nTPM
Heart muscle	58.9 nTPM
Endometrium	57.0 nTPM
Ovary	53.1 nTPM
Eye	52.6 nTPM
Lung	46.8 nTPM
Liver	41.2 nTPM
Skeletal muscle	40.7 nTPM
Testis	38.0 nTPM
Breast	38.0 nTPM
Pancreas	34.7 nTPM
Esophagus	28.3 nTPM
Prostate	28.1 nTPM
Placenta	25.0 nTPM
Skin	15.3 nTPM

Fibroblasts	48.4 nTPM
Adipose tissue	69.8 nTPM
Heart muscle	69.4 nTPM
Skeletal muscle	67.0 nTPM
Ovary	59.5 nTPM
Breast	58.4 nTPM
Lung	50.3 nTPM
Placenta	38.1 nTPM
Esophagus	35.1 nTPM
Stomach	32.7 nTPM
Skin	27.6 nTPM
Prostate	24.7 nTPM

Intestinal goblet cells	26.6 nTPM
Rectum	39.4 nTPM
Small intestine	26.1 nTPM
Colon	14.3 nTPM

Macrophages	23.3 nTPM
Ovary	37.8 nTPM
Endometrium	33.4 nTPM
Skeletal muscle	31.0 nTPM
Breast	30.5 nTPM
Adipose tissue	30.1 nTPM
Lung	28.9 nTPM
Spleen	24.9 nTPM
Pancreas	20.4 nTPM
Testis	18.6 nTPM
Stomach	17.6 nTPM
Bone marrow	17.5 nTPM
Kidney	16.6 nTPM
Esophagus	15.8 nTPM
PBMC	13.6 nTPM
Prostate	12.6 nTPM

Paneth cells	24.8 nTPM
Rectum	38.8 nTPM
Small intestine	22.5 nTPM
Colon	13.2 nTPM

Plasma cells	59.3 nTPM
Spleen	82.9 nTPM
Stomach	68.7 nTPM
Adipose tissue	62.5 nTPM
Bone marrow	57.7 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	56.4 nTPM
Lung	65.6 nTPM
Bronchus	47.2 nTPM

Smooth muscle cells	42.2 nTPM
Adipose tissue	79.2 nTPM
Breast	63.6 nTPM
Ovary	57.1 nTPM
Heart muscle	56.4 nTPM
Endometrium	54.8 nTPM
Skeletal muscle	49.0 nTPM
Prostate	31.9 nTPM
Pancreas	24.6 nTPM
Esophagus	21.7 nTPM
Skin	18.8 nTPM
Bronchus	7.5 nTPM

T-cells	34.3 nTPM
Adipose tissue	54.5 nTPM
Endometrium	52.0 nTPM
Skeletal muscle	49.2 nTPM
Breast	48.6 nTPM
Lung	47.1 nTPM
Ovary	46.7 nTPM
Colon	36.6 nTPM
Lymph node	35.4 nTPM
PBMC	34.7 nTPM
Spleen	32.4 nTPM
Stomach	31.0 nTPM
Bone marrow	25.7 nTPM
Liver	20.9 nTPM
Esophagus	19.7 nTPM
Skin	18.0 nTPM
Kidney	15.8 nTPM
Prostate	14.2 nTPM

Basal keratinocytes	13.8 nTPM
Skin	13.8 nTPM

Basal prostatic cells	24.2 nTPM
Prostate	24.2 nTPM

Basal respiratory cells	25.9 nTPM
Bronchus	25.9 nTPM

Basal squamous epithelial cells	19.9 nTPM
Esophagus	19.9 nTPM

Undifferentiated cells	33.8 nTPM
Rectum	48.0 nTPM
Colon	30.1 nTPM
Small intestine	23.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC