Single cell type - ITGB3BP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITGB3BP
Gene descriptionⁱ Full gene name according to HGNC.	Integrin subunit beta 3 binding protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ITGB3BP is part of cluster 12 Non-specific - Cell cycle regulation with confidenceⁱ 1
294 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CDC25C	Cell division cycle 25C	0.6975	12
CEP55	Centrosomal protein 55	0.6500	12
NUF2	NUF2 component of NDC80 kinetochore complex	0.6490	12
OIP5	Opa interacting protein 5	0.6412	12
TTK	TTK protein kinase	0.6356	66
NCAPH	Non-SMC condensin I complex subunit H	0.6315	12
NEK2	NIMA related kinase 2	0.6268	66
DEPDC1	DEP domain containing 1	0.6230	12
PBK	PDZ binding kinase	0.6089	66
KIF23	Kinesin family member 23	0.6082	12
AURKA	Aurora kinase A	0.6044	66
HIRIP3	HIRA interacting protein 3	0.5919	12
HJURP	Holliday junction recognition protein	0.5903	12
CCNB2	Cyclin B2	0.5880	12
PLK4	Polo like kinase 4	0.5741	12

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.0 nTPM
Breast	22.8 nTPM
Adipose tissue	21.2 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	13.9 nTPM
Lung	13.9 nTPM

Astrocytes	24.2 nTPM
Brain	24.2 nTPM

B-cells	40.9 nTPM
Liver	65.6 nTPM
Bone marrow	52.3 nTPM
Spleen	49.8 nTPM
Lymph node	46.3 nTPM
Colon	41.5 nTPM
Stomach	35.9 nTPM
Kidney	33.4 nTPM
PBMC	32.9 nTPM
Adipose tissue	26.1 nTPM
Breast	25.5 nTPM

Dendritic cells	19.3 nTPM
Breast	34.2 nTPM
Adipose tissue	19.6 nTPM
PBMC	4.0 nTPM

Endothelial cells	21.6 nTPM
Esophagus	30.9 nTPM
Placenta	30.1 nTPM
Skin	30.1 nTPM
Eye	26.7 nTPM
Breast	25.0 nTPM
Lung	24.9 nTPM
Liver	20.2 nTPM
Testis	20.1 nTPM
Endometrium	19.8 nTPM
Pancreas	15.5 nTPM
Skeletal muscle	15.4 nTPM
Ovary	15.3 nTPM
Prostate	14.6 nTPM
Heart muscle	13.3 nTPM

Fibroblasts	28.6 nTPM
Stomach	52.0 nTPM
Lung	45.8 nTPM
Breast	33.5 nTPM
Esophagus	32.5 nTPM
Ovary	32.4 nTPM
Placenta	27.6 nTPM
Skin	25.4 nTPM
Adipose tissue	23.2 nTPM
Prostate	15.4 nTPM
Heart muscle	13.7 nTPM
Skeletal muscle	13.2 nTPM

Intestinal goblet cells	18.1 nTPM
Colon	23.5 nTPM
Rectum	15.5 nTPM
Small intestine	15.3 nTPM

Macrophages	18.9 nTPM
PBMC	54.6 nTPM
Bone marrow	26.2 nTPM
Prostate	22.9 nTPM
Kidney	21.1 nTPM
Breast	21.1 nTPM
Endometrium	18.1 nTPM
Esophagus	17.3 nTPM
Testis	16.3 nTPM
Spleen	15.6 nTPM
Pancreas	15.3 nTPM
Adipose tissue	15.0 nTPM
Lung	14.6 nTPM
Ovary	13.7 nTPM
Skeletal muscle	8.9 nTPM
Stomach	2.9 nTPM

Paneth cells	4.1 nTPM
Rectum	12.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	30.7 nTPM
Spleen	46.7 nTPM
Bone marrow	34.6 nTPM
Stomach	32.5 nTPM
Esophagus	30.7 nTPM
Adipose tissue	9.1 nTPM

Respiratory ciliated cells	54.3 nTPM
Bronchus	67.7 nTPM
Lung	40.8 nTPM

Smooth muscle cells	21.9 nTPM
Pancreas	37.2 nTPM
Endometrium	26.4 nTPM
Skin	23.4 nTPM
Prostate	22.8 nTPM
Ovary	22.3 nTPM
Breast	22.0 nTPM
Esophagus	21.7 nTPM
Adipose tissue	21.0 nTPM
Bronchus	19.9 nTPM
Skeletal muscle	15.1 nTPM
Heart muscle	8.8 nTPM

T-cells	26.6 nTPM
Prostate	47.3 nTPM
Lymph node	41.5 nTPM
Liver	36.6 nTPM
Spleen	35.3 nTPM
Bone marrow	32.9 nTPM
Kidney	30.2 nTPM
Colon	28.5 nTPM
PBMC	27.4 nTPM
Stomach	26.6 nTPM
Esophagus	26.2 nTPM
Breast	24.7 nTPM
Skin	20.2 nTPM
Endometrium	19.9 nTPM
Adipose tissue	17.9 nTPM
Skeletal muscle	13.2 nTPM
Lung	12.2 nTPM
Ovary	11.1 nTPM

Basal keratinocytes	33.9 nTPM
Skin	33.9 nTPM

Basal prostatic cells	56.3 nTPM
Prostate	56.3 nTPM

Basal squamous epithelial cells	34.7 nTPM
Esophagus	34.7 nTPM

Collecting duct cells	25.8 nTPM
Kidney	25.8 nTPM

Undifferentiated cells	31.9 nTPM
Small intestine	41.9 nTPM
Rectum	27.6 nTPM
Colon	26.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC