Single cell type - ATP1B1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP1B1
Gene descriptionⁱ Full gene name according to HGNC.	ATPase Na+/K+ transporting subunit beta 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Collecting duct cells, Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19, RPTEC TERT1, SH-SY5Y)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Collecting duct cells, Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP1B1 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RNF5	Ring finger protein 5	0.6114	67
SLC16A9	Solute carrier family 16 member 9	0.5972	67
ABCC6	ATP binding cassette subfamily C member 6	0.5819	67
B3GNT4	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4	0.5708	67
PDZK1IP1	PDZK1 interacting protein 1	0.5560	67
FCAMR	Fc fragment of IgA and IgM receptor	0.5515	67
SLC22A2	Solute carrier family 22 member 2	0.5500	67
OR2T10	Olfactory receptor family 2 subfamily T member 10	0.5482	67
ANXA9	Annexin A9	0.5449	67
SLC47A2	Solute carrier family 47 member 2	0.5417	67
CCDC198	Coiled-coil domain containing 198	0.5417	67
SLC36A2	Solute carrier family 36 member 2	0.5409	67
TINAG	Tubulointerstitial nephritis antigen	0.5404	67
OR2T2	Olfactory receptor family 2 subfamily T member 2	0.5372	67
AUH	AU RNA binding methylglutaconyl-CoA hydratase	0.5314	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.4 nTPM
Adipose tissue	16.2 nTPM
Breast	12.7 nTPM

Alveolar cells type 1	240.4 nTPM
Lung	240.4 nTPM

Alveolar cells type 2	251.5 nTPM
Lung	251.5 nTPM

Astrocytes	79.0 nTPM
Brain	79.0 nTPM

B-cells	18.4 nTPM
Kidney	76.1 nTPM
Adipose tissue	31.5 nTPM
Colon	22.3 nTPM
Breast	20.0 nTPM
Liver	14.3 nTPM
Stomach	9.6 nTPM
Lymph node	5.8 nTPM
Spleen	3.5 nTPM
Bone marrow	0.8 nTPM
PBMC	0.0 nTPM

Basal squamous epithelial cells	153.1 nTPM
Esophagus	153.1 nTPM

Dendritic cells	21.0 nTPM
Adipose tissue	34.1 nTPM
Breast	28.8 nTPM
PBMC	0.0 nTPM

Distal enterocytes	817.1 nTPM
Rectum	1018.2 nTPM
Colon	615.9 nTPM

Endothelial cells	18.6 nTPM
Breast	34.7 nTPM
Eye	32.4 nTPM
Skeletal muscle	28.4 nTPM
Testis	26.6 nTPM
Endometrium	22.8 nTPM
Lung	21.8 nTPM
Skin	20.3 nTPM
Prostate	17.6 nTPM
Pancreas	11.6 nTPM
Liver	11.0 nTPM
Ovary	9.8 nTPM
Heart muscle	9.7 nTPM
Esophagus	8.8 nTPM
Placenta	5.1 nTPM

Enteroendocrine cells	160.9 nTPM
Rectum	179.6 nTPM
Colon	142.1 nTPM

Fibroblasts	78.7 nTPM
Lung	244.6 nTPM
Placenta	199.1 nTPM
Prostate	111.5 nTPM
Heart muscle	63.6 nTPM
Ovary	50.3 nTPM
Stomach	46.0 nTPM
Skeletal muscle	45.2 nTPM
Esophagus	39.0 nTPM
Breast	32.3 nTPM
Skin	18.4 nTPM
Adipose tissue	15.7 nTPM

Intestinal goblet cells	296.7 nTPM
Colon	355.2 nTPM
Rectum	274.3 nTPM
Small intestine	260.7 nTPM

Macrophages	101.5 nTPM
Ovary	250.4 nTPM
Adipose tissue	208.5 nTPM
Esophagus	151.1 nTPM
Breast	144.9 nTPM
Prostate	122.7 nTPM
Kidney	122.5 nTPM
Lung	115.6 nTPM
Endometrium	99.1 nTPM
Skeletal muscle	90.8 nTPM
Spleen	86.0 nTPM
Testis	44.7 nTPM
Bone marrow	43.7 nTPM
Stomach	29.4 nTPM
Pancreas	12.8 nTPM
PBMC	0.0 nTPM

Paneth cells	666.4 nTPM
Colon	734.5 nTPM
Rectum	679.0 nTPM
Small intestine	585.7 nTPM

Plasma cells	16.9 nTPM
Adipose tissue	42.5 nTPM
Esophagus	18.4 nTPM
Stomach	8.5 nTPM
Spleen	8.2 nTPM
Bone marrow	6.6 nTPM

Cholangiocytes	664.8 nTPM
Liver	664.8 nTPM

Cone photoreceptor cells	14.6 nTPM
Eye	14.6 nTPM

Cytotrophoblasts	4.8 nTPM
Placenta	4.8 nTPM

Early spermatids	3.8 nTPM
Testis	3.8 nTPM

Respiratory ciliated cells	332.5 nTPM
Bronchus	461.0 nTPM
Lung	204.0 nTPM

Smooth muscle cells	32.5 nTPM
Bronchus	108.1 nTPM
Prostate	56.6 nTPM
Ovary	51.1 nTPM
Pancreas	47.3 nTPM
Skin	22.7 nTPM
Esophagus	15.5 nTPM
Breast	15.3 nTPM
Endometrium	14.7 nTPM
Skeletal muscle	9.8 nTPM
Adipose tissue	9.5 nTPM
Heart muscle	7.5 nTPM

T-cells	48.2 nTPM
Adipose tissue	133.6 nTPM
Skin	120.2 nTPM
Endometrium	88.8 nTPM
Skeletal muscle	76.1 nTPM
Prostate	75.7 nTPM
Breast	71.7 nTPM
Kidney	67.1 nTPM
Esophagus	52.4 nTPM
Colon	40.9 nTPM
Lung	24.3 nTPM
Ovary	20.1 nTPM
Stomach	16.8 nTPM
Liver	15.1 nTPM
Lymph node	6.7 nTPM
Bone marrow	4.3 nTPM
Spleen	4.2 nTPM
PBMC	1.9 nTPM

Undifferentiated cells	436.0 nTPM
Colon	611.8 nTPM
Small intestine	371.4 nTPM
Rectum	324.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC