Single cell type - POGZ - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POGZ
Gene descriptionⁱ Full gene name according to HGNC.	Pogo transposable element derived with ZNF domain
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

POGZ is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TJAP1	Tight junction associated protein 1	0.6071	42
ABCA2	ATP binding cassette subfamily A member 2	0.5563	42
PLP1	Proteolipid protein 1	0.5350	42
MAG	Myelin associated glycoprotein	0.5304	42
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.5278	42
TESK2	Testis associated actin remodelling kinase 2	0.5269	42
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.5265	42
UGT8	UDP glycosyltransferase 8	0.5260	42
ERMN	Ermin	0.5254	42
ST18	ST18 C2H2C-type zinc finger transcription factor	0.5226	42
MOG	Myelin oligodendrocyte glycoprotein	0.5215	42
MYBBP1A	MYB binding protein 1a	0.5198	39
TMEM235	Transmembrane protein 235	0.5173	42
RNF220	Ring finger protein 220	0.5111	42
PLEKHG1	Pleckstrin homology and RhoGEF domain containing G1	0.5085	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	42.7 nTPM
Adipose tissue	51.7 nTPM
Breast	33.7 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	41.6 nTPM
Lung	41.6 nTPM

Astrocytes	167.8 nTPM
Brain	167.8 nTPM

B-cells	60.6 nTPM
Stomach	94.9 nTPM
Lymph node	93.5 nTPM
Bone marrow	74.4 nTPM
Colon	73.5 nTPM
Spleen	70.2 nTPM
PBMC	64.2 nTPM
Breast	52.2 nTPM
Adipose tissue	45.6 nTPM
Liver	23.1 nTPM
Kidney	14.3 nTPM

Dendritic cells	34.4 nTPM
Adipose tissue	44.0 nTPM
Breast	31.3 nTPM
PBMC	27.9 nTPM

Endothelial cells	45.0 nTPM
Endometrium	56.9 nTPM
Esophagus	56.3 nTPM
Liver	55.9 nTPM
Prostate	52.2 nTPM
Skeletal muscle	52.0 nTPM
Lung	46.8 nTPM
Ovary	46.5 nTPM
Heart muscle	46.0 nTPM
Skin	45.2 nTPM
Breast	44.5 nTPM
Testis	44.2 nTPM
Placenta	35.8 nTPM
Eye	35.6 nTPM
Pancreas	11.6 nTPM

Fibroblasts	40.2 nTPM
Esophagus	54.0 nTPM
Ovary	52.1 nTPM
Skin	49.9 nTPM
Skeletal muscle	47.3 nTPM
Breast	39.9 nTPM
Adipose tissue	39.8 nTPM
Lung	38.0 nTPM
Prostate	35.4 nTPM
Stomach	31.2 nTPM
Placenta	30.1 nTPM
Heart muscle	24.0 nTPM

Intestinal goblet cells	32.4 nTPM
Rectum	34.4 nTPM
Small intestine	32.6 nTPM
Colon	30.0 nTPM

Macrophages	32.8 nTPM
Adipose tissue	57.3 nTPM
Prostate	52.7 nTPM
Esophagus	51.9 nTPM
Ovary	42.1 nTPM
Skeletal muscle	39.5 nTPM
Breast	33.7 nTPM
Bone marrow	32.4 nTPM
Stomach	32.2 nTPM
Endometrium	30.0 nTPM
Testis	29.1 nTPM
Spleen	29.0 nTPM
Kidney	28.0 nTPM
Lung	23.4 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	26.3 nTPM
Small intestine	30.0 nTPM
Rectum	29.1 nTPM
Colon	19.7 nTPM

Plasma cells	58.9 nTPM
Esophagus	67.8 nTPM
Adipose tissue	66.5 nTPM
Stomach	58.6 nTPM
Spleen	52.0 nTPM
Bone marrow	49.4 nTPM

Respiratory ciliated cells	29.7 nTPM
Bronchus	39.1 nTPM
Lung	20.4 nTPM

Smooth muscle cells	41.3 nTPM
Skeletal muscle	63.6 nTPM
Adipose tissue	58.7 nTPM
Endometrium	51.5 nTPM
Ovary	50.5 nTPM
Esophagus	48.0 nTPM
Skin	44.6 nTPM
Breast	36.8 nTPM
Prostate	36.6 nTPM
Heart muscle	28.1 nTPM
Bronchus	20.9 nTPM
Pancreas	14.4 nTPM

T-cells	39.9 nTPM
Lymph node	74.2 nTPM
Bone marrow	54.8 nTPM
Adipose tissue	52.4 nTPM
Spleen	52.1 nTPM
Skeletal muscle	49.2 nTPM
Skin	47.8 nTPM
Stomach	45.9 nTPM
Endometrium	36.0 nTPM
PBMC	35.1 nTPM
Prostate	33.1 nTPM
Colon	32.3 nTPM
Kidney	30.2 nTPM
Breast	29.7 nTPM
Lung	27.4 nTPM
Ovary	26.7 nTPM
Esophagus	26.2 nTPM
Liver	24.8 nTPM

Basal prostatic cells	26.8 nTPM
Prostate	26.8 nTPM

Basal respiratory cells	25.2 nTPM
Bronchus	25.2 nTPM

Basal squamous epithelial cells	54.1 nTPM
Esophagus	54.1 nTPM

Cholangiocytes	37.1 nTPM
Liver	37.1 nTPM

Undifferentiated cells	36.4 nTPM
Small intestine	40.6 nTPM
Rectum	36.3 nTPM
Colon	32.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC