Single cell type - TTC13 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TTC13
Gene descriptionⁱ Full gene name according to HGNC.	Tetratricopeptide repeat domain 13
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocytes, Microglial cells, Astrocytes, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocytes, Microglial cells, Astrocytes, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TTC13 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TBC1D31	TBC1 domain family member 31	0.6480	63
ZNF718	Zinc finger protein 718	0.6227	42
EXOC2	Exocyst complex component 2	0.6109	8
ZNF41	Zinc finger protein 41	0.5932	8
AMBRA1	Autophagy and beclin 1 regulator 1	0.5533	42
RAD52	RAD52 homolog, DNA repair protein	0.5464	8
COG5	Component of oligomeric golgi complex 5	0.5408	8
MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2	0.5348	42
AUTS2	Activator of transcription and developmental regulator AUTS2	0.5313	8
FBXL17	F-box and leucine rich repeat protein 17	0.5281	8
KDM4C	Lysine demethylase 4C	0.5214	42
TBC1D5	TBC1 domain family member 5	0.5172	42
PRKACB	Protein kinase cAMP-activated catalytic subunit beta	0.5150	42
GAS2	Growth arrest specific 2	0.5134	8
GAL3ST2	Galactose-3-O-sulfotransferase 2	0.5080	58

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.2 nTPM
Breast	7.8 nTPM
Adipose tissue	6.6 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	7.4 nTPM
Lung	7.4 nTPM

B-cells	18.9 nTPM
Bone marrow	35.1 nTPM
Spleen	23.9 nTPM
Kidney	23.8 nTPM
Stomach	22.3 nTPM
Breast	20.0 nTPM
Lymph node	17.2 nTPM
Colon	16.0 nTPM
Adipose tissue	12.6 nTPM
PBMC	11.5 nTPM
Liver	6.2 nTPM

Basal keratinocytes	3.3 nTPM
Skin	3.3 nTPM

Dendritic cells	21.8 nTPM
Breast	25.2 nTPM
Adipose tissue	24.2 nTPM
PBMC	16.0 nTPM

Endothelial cells	5.4 nTPM
Skeletal muscle	10.7 nTPM
Heart muscle	10.6 nTPM
Ovary	10.6 nTPM
Placenta	6.8 nTPM
Breast	6.3 nTPM
Lung	6.2 nTPM
Eye	5.7 nTPM
Endometrium	4.9 nTPM
Testis	3.8 nTPM
Liver	3.7 nTPM
Skin	3.7 nTPM
Esophagus	2.1 nTPM
Prostate	1.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	5.2 nTPM
Heart muscle	11.6 nTPM
Lung	11.1 nTPM
Skeletal muscle	5.9 nTPM
Breast	4.5 nTPM
Stomach	4.4 nTPM
Ovary	4.3 nTPM
Adipose tissue	4.2 nTPM
Skin	3.7 nTPM
Esophagus	3.5 nTPM
Placenta	2.9 nTPM
Prostate	1.2 nTPM

Intestinal goblet cells	11.3 nTPM
Rectum	14.6 nTPM
Colon	13.6 nTPM
Small intestine	5.8 nTPM

Macrophages	8.9 nTPM
Stomach	20.5 nTPM
Bone marrow	13.8 nTPM
Spleen	13.5 nTPM
Breast	11.2 nTPM
Lung	10.9 nTPM
Testis	10.5 nTPM
Skeletal muscle	9.8 nTPM
Adipose tissue	9.4 nTPM
Endometrium	7.9 nTPM
Kidney	7.6 nTPM
Esophagus	6.3 nTPM
Pancreas	5.1 nTPM
Ovary	5.1 nTPM
Prostate	2.2 nTPM
PBMC	0.0 nTPM

Paneth cells	8.7 nTPM
Rectum	16.2 nTPM
Colon	9.9 nTPM
Small intestine	0.0 nTPM

Plasma cells	13.6 nTPM
Adipose tissue	27.1 nTPM
Stomach	12.1 nTPM
Bone marrow	11.5 nTPM
Spleen	11.0 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	1.3 nTPM
Bronchus	2.6 nTPM
Lung	0.0 nTPM

Smooth muscle cells	4.9 nTPM
Heart muscle	9.2 nTPM
Bronchus	7.6 nTPM
Breast	5.8 nTPM
Ovary	5.6 nTPM
Pancreas	5.0 nTPM
Adipose tissue	4.5 nTPM
Prostate	4.3 nTPM
Endometrium	4.3 nTPM
Skeletal muscle	3.6 nTPM
Skin	2.5 nTPM
Esophagus	1.5 nTPM

T-cells	16.9 nTPM
Bone marrow	43.9 nTPM
Stomach	25.8 nTPM
Breast	23.2 nTPM
Spleen	22.6 nTPM
Ovary	22.3 nTPM
Liver	17.6 nTPM
Adipose tissue	17.2 nTPM
Lung	16.7 nTPM
Skeletal muscle	15.2 nTPM
Kidney	13.7 nTPM
Skin	12.9 nTPM
PBMC	12.6 nTPM
Lymph node	12.5 nTPM
Endometrium	10.8 nTPM
Colon	9.0 nTPM
Esophagus	6.6 nTPM
Prostate	4.7 nTPM

Astrocytes	42.7 nTPM
Brain	42.7 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Early spermatids	1.7 nTPM
Testis	1.7 nTPM

Undifferentiated cells	9.4 nTPM
Rectum	13.1 nTPM
Colon	8.7 nTPM
Small intestine	6.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC