Single cell type - ACP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACP1
Gene descriptionⁱ Full gene name according to HGNC.	Acid phosphatase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACP1 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TFAM	Transcription factor A, mitochondrial	0.8118	34
NT5C1B-RDH14	NT5C1B-RDH14 readthrough	0.7795	34
ATAD1	ATPase family AAA domain containing 1	0.7504	34
HARBI1	Harbinger transposase derived 1	0.7490	34
BAG5	BAG cochaperone 5	0.7398	34
PRSS51	Serine protease 51	0.7381	34
HSFY1	Heat shock transcription factor Y-linked 1	0.7371	34
FAM205C	Family with sequence similarity 205 member C	0.7359	34
CEP112	Centrosomal protein 112	0.7246	34
DEFB136	Defensin beta 136	0.7224	34
MKRN2	Makorin ring finger protein 2	0.7198	34
GRXCR2	Glutaredoxin and cysteine rich domain containing 2	0.7106	34
INPP1	Inositol polyphosphate-1-phosphatase	0.7083	34
FBXO39	F-box protein 39	0.7078	34
TTLL2	Tubulin tyrosine ligase like 2	0.6952	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	62.5 nTPM
Breast	78.5 nTPM
Adipose tissue	46.5 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	96.7 nTPM
Lung	96.7 nTPM

Astrocytes	9.1 nTPM
Brain	9.1 nTPM

B-cells	102.6 nTPM
Liver	189.9 nTPM
PBMC	141.4 nTPM
Colon	121.4 nTPM
Breast	96.4 nTPM
Kidney	95.3 nTPM
Spleen	89.3 nTPM
Bone marrow	79.3 nTPM
Stomach	78.1 nTPM
Adipose tissue	72.7 nTPM
Lymph node	62.2 nTPM

Dendritic cells	101.3 nTPM
PBMC	111.6 nTPM
Breast	102.7 nTPM
Adipose tissue	89.5 nTPM

Endothelial cells	70.6 nTPM
Pancreas	131.3 nTPM
Prostate	94.5 nTPM
Placenta	92.1 nTPM
Testis	88.6 nTPM
Skin	82.3 nTPM
Breast	81.2 nTPM
Heart muscle	63.9 nTPM
Ovary	62.3 nTPM
Liver	54.1 nTPM
Lung	53.0 nTPM
Eye	52.6 nTPM
Endometrium	46.9 nTPM
Esophagus	45.7 nTPM
Skeletal muscle	39.3 nTPM

Erythroid cells	291.5 nTPM
Liver	481.3 nTPM
Bone marrow	101.7 nTPM

Fibroblasts	74.2 nTPM
Placenta	115.9 nTPM
Ovary	107.2 nTPM
Lung	87.1 nTPM
Prostate	79.9 nTPM
Heart muscle	76.2 nTPM
Skin	68.4 nTPM
Breast	67.2 nTPM
Adipose tissue	66.7 nTPM
Stomach	56.4 nTPM
Esophagus	48.6 nTPM
Skeletal muscle	42.4 nTPM

Intestinal goblet cells	125.1 nTPM
Colon	149.4 nTPM
Small intestine	113.8 nTPM
Rectum	112.2 nTPM

Macrophages	74.6 nTPM
Pancreas	130.2 nTPM
PBMC	122.7 nTPM
Kidney	90.0 nTPM
Ovary	84.6 nTPM
Testis	83.0 nTPM
Breast	81.6 nTPM
Prostate	79.2 nTPM
Lung	73.0 nTPM
Endometrium	67.0 nTPM
Esophagus	61.4 nTPM
Adipose tissue	58.0 nTPM
Bone marrow	52.4 nTPM
Stomach	46.9 nTPM
Spleen	45.6 nTPM
Skeletal muscle	43.1 nTPM

Paneth cells	109.2 nTPM
Rectum	125.5 nTPM
Small intestine	116.4 nTPM
Colon	85.7 nTPM

Plasma cells	106.4 nTPM
Spleen	165.4 nTPM
Stomach	131.9 nTPM
Bone marrow	128.6 nTPM
Esophagus	55.5 nTPM
Adipose tissue	50.3 nTPM

Respiratory ciliated cells	128.1 nTPM
Lung	141.4 nTPM
Bronchus	114.7 nTPM

Smooth muscle cells	87.0 nTPM
Pancreas	195.5 nTPM
Bronchus	163.0 nTPM
Ovary	115.2 nTPM
Heart muscle	90.8 nTPM
Prostate	89.1 nTPM
Breast	71.9 nTPM
Skin	68.0 nTPM
Adipose tissue	46.0 nTPM
Endometrium	41.9 nTPM
Skeletal muscle	38.1 nTPM
Esophagus	37.2 nTPM

Basal prostatic cells	105.3 nTPM
Prostate	105.3 nTPM

Basal respiratory cells	173.4 nTPM
Bronchus	173.4 nTPM

Basal squamous epithelial cells	51.8 nTPM
Esophagus	51.8 nTPM

Cholangiocytes	131.5 nTPM
Liver	131.5 nTPM

T-cells	86.0 nTPM
PBMC	133.0 nTPM
Kidney	128.0 nTPM
Colon	112.6 nTPM
Liver	112.3 nTPM
Lung	97.2 nTPM
Breast	96.1 nTPM
Ovary	93.4 nTPM
Skin	88.9 nTPM
Adipose tissue	77.8 nTPM
Bone marrow	70.9 nTPM
Spleen	70.0 nTPM
Stomach	69.4 nTPM
Lymph node	69.2 nTPM
Esophagus	65.5 nTPM
Prostate	61.6 nTPM
Endometrium	59.8 nTPM
Skeletal muscle	55.8 nTPM

Undifferentiated cells	143.9 nTPM
Small intestine	166.7 nTPM
Colon	150.7 nTPM
Rectum	114.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC