Single cell type - ITPKB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITPKB
Gene descriptionⁱ Full gene name according to HGNC.	Inositol-trisphosphate 3-kinase B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Astrocytes - Nervous system maintenance (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Astrocytes, Oligodendrocytes, Adipocytes, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Astrocytes, Oligodendrocytes, Adipocytes, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ITPKB is part of cluster 64 Astrocytes - Nervous system maintenance with confidenceⁱ 1
169 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LRRC3C	Leucine rich repeat containing 3C	0.5428	64
PLXNB3	Plexin B3	0.5389	64
PITPNC1	Phosphatidylinositol transfer protein cytoplasmic 1	0.5385	64
NPFF	Neuropeptide FF-amide peptide precursor	0.5307	64
HIF3A	Hypoxia inducible factor 3 subunit alpha	0.5269	14
MLC1	Modulator of VRAC current 1	0.5250	64
INO80D	INO80 complex subunit D	0.5226	44
NTSR2	Neurotensin receptor 2	0.5219	64
PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2	0.5122	64
PSD2	Pleckstrin and Sec7 domain containing 2	0.5066	64
ETNPPL	Ethanolamine-phosphate phospho-lyase	0.5042	64
SLCO1C1	Solute carrier organic anion transporter family member 1C1	0.5018	64
HEPACAM	Hepatic and glial cell adhesion molecule	0.5013	64
RAPGEF3	Rap guanine nucleotide exchange factor 3	0.4971	14
GFAP	Glial fibrillary acidic protein	0.4964	64

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	7.4 nTPM
Lung	7.4 nTPM

B-cells	16.0 nTPM
Adipose tissue	58.7 nTPM
Colon	20.8 nTPM
Lymph node	18.6 nTPM
Bone marrow	13.1 nTPM
PBMC	12.9 nTPM
Liver	12.1 nTPM
Spleen	10.7 nTPM
Stomach	6.8 nTPM
Breast	6.6 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	12.2 nTPM
Skin	12.2 nTPM

Basal prostatic cells	4.8 nTPM
Prostate	4.8 nTPM

Dendritic cells	28.9 nTPM
Adipose tissue	49.5 nTPM
Breast	33.2 nTPM
PBMC	4.0 nTPM

Endothelial cells	42.2 nTPM
Heart muscle	105.3 nTPM
Skeletal muscle	69.5 nTPM
Ovary	69.4 nTPM
Skin	54.2 nTPM
Prostate	43.9 nTPM
Testis	41.2 nTPM
Liver	34.8 nTPM
Lung	34.3 nTPM
Breast	29.0 nTPM
Esophagus	28.8 nTPM
Placenta	25.0 nTPM
Pancreas	23.1 nTPM
Endometrium	20.0 nTPM
Eye	12.2 nTPM

Fibroblasts	8.9 nTPM
Skin	27.9 nTPM
Prostate	11.8 nTPM
Skeletal muscle	9.5 nTPM
Heart muscle	9.2 nTPM
Stomach	8.9 nTPM
Esophagus	6.2 nTPM
Breast	6.0 nTPM
Placenta	5.9 nTPM
Adipose tissue	4.8 nTPM
Ovary	4.4 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	2.8 nTPM
Small intestine	4.2 nTPM
Rectum	2.8 nTPM
Colon	1.4 nTPM

Macrophages	14.4 nTPM
Adipose tissue	33.2 nTPM
Prostate	22.9 nTPM
Ovary	22.2 nTPM
Skeletal muscle	19.3 nTPM
Esophagus	18.9 nTPM
Spleen	15.6 nTPM
Bone marrow	13.8 nTPM
PBMC	13.6 nTPM
Breast	13.1 nTPM
Kidney	9.9 nTPM
Endometrium	9.9 nTPM
Stomach	8.8 nTPM
Lung	8.0 nTPM
Testis	7.5 nTPM
Pancreas	0.0 nTPM

Paneth cells	3.7 nTPM
Small intestine	7.5 nTPM
Rectum	3.6 nTPM
Colon	0.0 nTPM

Plasma cells	11.8 nTPM
Adipose tissue	47.7 nTPM
Bone marrow	6.6 nTPM
Spleen	4.0 nTPM
Stomach	0.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	2.6 nTPM
Lung	2.9 nTPM
Bronchus	2.3 nTPM

Smooth muscle cells	16.3 nTPM
Prostate	43.7 nTPM
Skin	35.5 nTPM
Heart muscle	25.7 nTPM
Skeletal muscle	18.5 nTPM
Esophagus	17.0 nTPM
Breast	10.6 nTPM
Endometrium	10.5 nTPM
Adipose tissue	8.9 nTPM
Ovary	5.9 nTPM
Pancreas	1.5 nTPM
Bronchus	0.9 nTPM

T-cells	35.2 nTPM
Adipose tissue	120.0 nTPM
Skin	81.5 nTPM
Skeletal muscle	56.3 nTPM
PBMC	42.6 nTPM
Lymph node	41.6 nTPM
Endometrium	34.2 nTPM
Breast	33.1 nTPM
Liver	30.6 nTPM
Spleen	29.8 nTPM
Colon	24.2 nTPM
Bone marrow	21.4 nTPM
Stomach	19.1 nTPM
Ovary	15.6 nTPM
Kidney	13.7 nTPM
Esophagus	13.1 nTPM
Lung	12.2 nTPM
Prostate	9.5 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cytotrophoblasts	0.6 nTPM
Placenta	0.6 nTPM

Distal enterocytes	1.2 nTPM
Colon	1.7 nTPM
Rectum	0.8 nTPM

Distal tubular cells	3.9 nTPM
Kidney	3.9 nTPM

Undifferentiated cells	3.1 nTPM
Rectum	3.5 nTPM
Colon	2.8 nTPM
Small intestine	2.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC