Single cell type - PARP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PARP1
Gene descriptionⁱ Full gene name according to HGNC.	Poly(ADP-ribose) polymerase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PARP1 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SOX14	SRY-box transcription factor 14	0.7630	47
SMIM43	Small integral membrane protein 43	0.7516	47
IL36RN	Interleukin 36 receptor antagonist	0.7495	47
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.7480	47
MORC4	MORC family CW-type zinc finger 4	0.7428	47
PAGE4	PAGE family member 4	0.7372	47
GSDME	Gasdermin E	0.7342	47
MTARC1	Mitochondrial amidoxime reducing component 1	0.7263	47
CBY2	Chibby family member 2	0.7218	47
RMI2	RecQ mediated genome instability 2	0.7205	47
L1TD1	LINE1 type transposase domain containing 1	0.7166	47
FBN2	Fibrillin 2	0.7156	47
LARGE2	LARGE xylosyl- and glucuronyltransferase 2	0.7117	47
NXPH4	Neurexophilin 4	0.7105	47
MYORG	Myogenesis regulating glycosidase (putative)	0.7058	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.4 nTPM
Breast	38.3 nTPM
Adipose tissue	28.4 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	73.6 nTPM
Lung	73.6 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	169.1 nTPM
Liver	232.5 nTPM
Bone marrow	229.7 nTPM
Spleen	210.0 nTPM
PBMC	209.9 nTPM
Stomach	177.1 nTPM
Kidney	166.7 nTPM
Lymph node	161.3 nTPM
Colon	111.8 nTPM
Adipose tissue	98.3 nTPM
Breast	93.5 nTPM

Dendritic cells	53.8 nTPM
PBMC	67.8 nTPM
Adipose tissue	52.8 nTPM
Breast	40.9 nTPM

Endothelial cells	62.0 nTPM
Placenta	104.0 nTPM
Eye	85.7 nTPM
Heart muscle	73.3 nTPM
Ovary	72.3 nTPM
Lung	68.6 nTPM
Esophagus	64.2 nTPM
Endometrium	63.9 nTPM
Testis	58.7 nTPM
Prostate	56.5 nTPM
Breast	50.2 nTPM
Skin	48.2 nTPM
Skeletal muscle	47.4 nTPM
Pancreas	38.6 nTPM
Liver	36.7 nTPM

Erythroid cells	100.5 nTPM
Bone marrow	158.1 nTPM
Liver	42.9 nTPM

Fibroblasts	49.8 nTPM
Ovary	113.1 nTPM
Placenta	101.0 nTPM
Heart muscle	73.8 nTPM
Lung	60.3 nTPM
Skeletal muscle	34.9 nTPM
Prostate	31.6 nTPM
Breast	29.0 nTPM
Skin	27.8 nTPM
Stomach	26.7 nTPM
Adipose tissue	25.4 nTPM
Esophagus	24.1 nTPM

Intestinal goblet cells	50.0 nTPM
Colon	62.9 nTPM
Rectum	46.3 nTPM
Small intestine	40.7 nTPM

Macrophages	48.3 nTPM
Esophagus	75.5 nTPM
Lung	71.8 nTPM
Ovary	65.1 nTPM
Bone marrow	63.7 nTPM
Endometrium	59.8 nTPM
Pancreas	53.7 nTPM
Testis	51.2 nTPM
Spleen	50.8 nTPM
Kidney	48.5 nTPM
Skeletal muscle	48.5 nTPM
Prostate	48.2 nTPM
Breast	45.2 nTPM
Adipose tissue	36.3 nTPM
Stomach	5.9 nTPM
PBMC	0.0 nTPM

Paneth cells	24.2 nTPM
Rectum	36.4 nTPM
Small intestine	26.3 nTPM
Colon	9.9 nTPM

Plasma cells	186.9 nTPM
Bone marrow	293.3 nTPM
Spleen	272.7 nTPM
Stomach	164.4 nTPM
Esophagus	160.2 nTPM
Adipose tissue	43.9 nTPM

Respiratory ciliated cells	56.4 nTPM
Lung	81.6 nTPM
Bronchus	31.1 nTPM

Smooth muscle cells	48.0 nTPM
Ovary	83.8 nTPM
Pancreas	67.1 nTPM
Endometrium	66.4 nTPM
Prostate	53.8 nTPM
Heart muscle	52.2 nTPM
Bronchus	39.5 nTPM
Skin	39.0 nTPM
Skeletal muscle	34.7 nTPM
Esophagus	34.1 nTPM
Breast	31.3 nTPM
Adipose tissue	25.8 nTPM

Basal prostatic cells	83.9 nTPM
Prostate	83.9 nTPM

Cholangiocytes	44.3 nTPM
Liver	44.3 nTPM

Collecting duct cells	57.0 nTPM
Kidney	57.0 nTPM

Cone photoreceptor cells	141.8 nTPM
Eye	141.8 nTPM

T-cells	85.0 nTPM
Lung	126.0 nTPM
PBMC	122.2 nTPM
Kidney	102.7 nTPM
Bone marrow	99.5 nTPM
Esophagus	98.3 nTPM
Stomach	94.2 nTPM
Liver	91.2 nTPM
Colon	86.0 nTPM
Prostate	80.4 nTPM
Lymph node	80.3 nTPM
Spleen	78.3 nTPM
Skeletal muscle	76.9 nTPM
Ovary	66.8 nTPM
Skin	65.4 nTPM
Adipose tissue	63.1 nTPM
Endometrium	60.1 nTPM
Breast	53.9 nTPM

Undifferentiated cells	61.9 nTPM
Colon	72.3 nTPM
Small intestine	65.7 nTPM
Rectum	47.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC