Single cell type - KANSL1L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KANSL1L
Gene descriptionⁱ Full gene name according to HGNC.	KAT8 regulatory NSL complex subunit 1 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Astrocytes, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Astrocytes, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KANSL1L is part of cluster 68 Oligodendrocytes - Mixed function with confidenceⁱ 1
161 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FHIT	Fragile histidine triad diadenosine triphosphatase	0.6708	68
WWOX	WW domain containing oxidoreductase	0.6630	42
NAV2	Neuron navigator 2	0.6458	68
TMEM132C	Transmembrane protein 132C	0.6177	68
BBS9	Bardet-Biedl syndrome 9	0.6176	42
DISP1	Dispatched RND transporter family member 1	0.6134	68
UST	Uronyl 2-sulfotransferase	0.6106	68
ROR1	Receptor tyrosine kinase like orphan receptor 1	0.6091	8
ZNF704	Zinc finger protein 704	0.6001	68
BMPR1A	Bone morphogenetic protein receptor type 1A	0.5866	68
ARMCX4	Armadillo repeat containing X-linked 4	0.5802	8
LUZP2	Leucine zipper protein 2	0.5698	68
NAV1	Neuron navigator 1	0.5675	68
INVS	Inversin	0.5637	42
NLGN4X	Neuroligin 4 X-linked	0.5565	68

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.8 nTPM
Breast	14.8 nTPM
Adipose tissue	10.7 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	20.1 nTPM
Lung	20.1 nTPM

B-cells	4.6 nTPM
Adipose tissue	10.0 nTPM
Breast	9.4 nTPM
Bone marrow	7.4 nTPM
Lymph node	6.2 nTPM
Colon	3.2 nTPM
PBMC	2.8 nTPM
Stomach	2.7 nTPM
Liver	2.1 nTPM
Spleen	1.7 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	7.4 nTPM
Skin	7.4 nTPM

Dendritic cells	1.5 nTPM
Adipose tissue	3.0 nTPM
Breast	1.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	8.8 nTPM
Prostate	16.9 nTPM
Skeletal muscle	14.6 nTPM
Eye	10.5 nTPM
Heart muscle	10.4 nTPM
Esophagus	10.3 nTPM
Ovary	9.7 nTPM
Breast	9.6 nTPM
Testis	9.5 nTPM
Skin	9.3 nTPM
Endometrium	9.2 nTPM
Liver	4.6 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM
Placenta	1.1 nTPM

Fibroblasts	14.2 nTPM
Prostate	25.3 nTPM
Esophagus	21.0 nTPM
Skeletal muscle	18.7 nTPM
Adipose tissue	17.2 nTPM
Heart muscle	14.1 nTPM
Ovary	13.1 nTPM
Skin	12.2 nTPM
Stomach	11.9 nTPM
Breast	10.7 nTPM
Lung	10.1 nTPM
Placenta	1.8 nTPM

Intestinal goblet cells	3.2 nTPM
Rectum	4.1 nTPM
Colon	3.6 nTPM
Small intestine	1.8 nTPM

Macrophages	8.5 nTPM
Adipose tissue	19.9 nTPM
Breast	14.4 nTPM
Skeletal muscle	14.1 nTPM
Spleen	11.4 nTPM
Endometrium	11.3 nTPM
Esophagus	9.4 nTPM
Bone marrow	8.7 nTPM
Prostate	8.1 nTPM
Kidney	7.6 nTPM
Ovary	6.9 nTPM
Testis	5.8 nTPM
Lung	4.8 nTPM
Stomach	2.9 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	4.7 nTPM
Small intestine	11.3 nTPM
Rectum	2.7 nTPM
Colon	0.0 nTPM

Plasma cells	3.0 nTPM
Esophagus	6.1 nTPM
Stomach	4.9 nTPM
Adipose tissue	3.3 nTPM
Spleen	0.6 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	36.0 nTPM
Lung	48.1 nTPM
Bronchus	23.9 nTPM

Smooth muscle cells	15.6 nTPM
Adipose tissue	21.8 nTPM
Prostate	21.3 nTPM
Ovary	20.9 nTPM
Endometrium	19.9 nTPM
Esophagus	18.6 nTPM
Breast	18.2 nTPM
Skeletal muscle	17.1 nTPM
Bronchus	12.3 nTPM
Heart muscle	10.2 nTPM
Skin	9.4 nTPM
Pancreas	1.7 nTPM

T-cells	2.7 nTPM
Lung	6.1 nTPM
Endometrium	5.3 nTPM
Prostate	4.7 nTPM
Skeletal muscle	4.7 nTPM
Lymph node	4.7 nTPM
Breast	4.0 nTPM
Kidney	3.4 nTPM
Adipose tissue	2.8 nTPM
Skin	2.3 nTPM
Bone marrow	2.2 nTPM
Liver	1.9 nTPM
Spleen	1.3 nTPM
PBMC	1.2 nTPM
Stomach	0.7 nTPM
Colon	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Astrocytes	113.6 nTPM
Brain	113.6 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Collecting duct cells	31.3 nTPM
Kidney	31.3 nTPM

Early spermatids	30.3 nTPM
Testis	30.3 nTPM

Undifferentiated cells	2.8 nTPM
Small intestine	3.6 nTPM
Rectum	2.7 nTPM
Colon	2.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC