Single cell type - CTDSPL - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTDSPL
Gene descriptionⁱ Full gene name according to HGNC.	CTD small phosphatase like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons, Astrocytes, Inhibitory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTCEpi)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Astrocytes, Inhibitory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CTDSPL is part of cluster 21 Neurons & Oligodendrocytes - Neuronal signaling with confidenceⁱ 1
589 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SNED1	Sushi, nidogen and EGF like domains 1	0.6857	21
LAMA2	Laminin subunit alpha 2	0.6062	50
MED12L	Mediator complex subunit 12L	0.5861	21
SLC6A7	Solute carrier family 6 member 7	0.5745	21
FLRT2	Fibronectin leucine rich transmembrane protein 2	0.5373	21
LMO3	LIM domain only 3	0.5358	21
MCHR2	Melanin concentrating hormone receptor 2	0.5303	21
FAT3	FAT atypical cadherin 3	0.5303	21
PDE5A	Phosphodiesterase 5A	0.5280	48
SATB2	SATB homeobox 2	0.5228	21
EPHA4	EPH receptor A4	0.5224	21
BTBD9	BTB domain containing 9	0.5216	21
OR14I1	Olfactory receptor family 14 subfamily I member 1	0.5208	21
OR9Q1	Olfactory receptor family 9 subfamily Q member 1	0.5201	21
ROCK2	Rho associated coiled-coil containing protein kinase 2	0.5195	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.8 nTPM
Breast	31.2 nTPM
Adipose tissue	22.4 nTPM

Alveolar cells type 1	67.3 nTPM
Lung	67.3 nTPM

Alveolar cells type 2	27.6 nTPM
Lung	27.6 nTPM

B-cells	1.2 nTPM
Kidney	4.8 nTPM
PBMC	2.8 nTPM
Breast	2.6 nTPM
Liver	1.3 nTPM
Colon	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	30.1 nTPM
Skin	30.1 nTPM

Dendritic cells	1.0 nTPM
Breast	2.9 nTPM
Adipose tissue	0.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	22.4 nTPM
Ovary	92.7 nTPM
Heart muscle	37.1 nTPM
Skeletal muscle	33.2 nTPM
Eye	28.3 nTPM
Breast	24.4 nTPM
Testis	19.6 nTPM
Lung	18.7 nTPM
Skin	14.9 nTPM
Liver	14.7 nTPM
Placenta	10.8 nTPM
Endometrium	6.1 nTPM
Esophagus	5.7 nTPM
Pancreas	3.9 nTPM
Prostate	3.7 nTPM

Fibroblasts	32.4 nTPM
Adipose tissue	69.0 nTPM
Ovary	61.9 nTPM
Skeletal muscle	54.9 nTPM
Heart muscle	43.5 nTPM
Breast	35.9 nTPM
Skin	26.7 nTPM
Placenta	17.4 nTPM
Lung	15.7 nTPM
Esophagus	14.6 nTPM
Prostate	10.5 nTPM
Stomach	6.0 nTPM

Intestinal goblet cells	18.5 nTPM
Rectum	33.0 nTPM
Small intestine	17.3 nTPM
Colon	5.0 nTPM

Macrophages	11.3 nTPM
PBMC	81.8 nTPM
Ovary	30.6 nTPM
Skeletal muscle	12.0 nTPM
Endometrium	9.2 nTPM
Adipose tissue	8.2 nTPM
Lung	7.0 nTPM
Kidney	6.8 nTPM
Testis	5.8 nTPM
Breast	4.3 nTPM
Esophagus	3.1 nTPM
Prostate	1.2 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	17.9 nTPM
Rectum	43.4 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	0.4 nTPM
Adipose tissue	1.9 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	12.4 nTPM
Lung	16.0 nTPM
Bronchus	8.8 nTPM

Smooth muscle cells	40.4 nTPM
Heart muscle	93.9 nTPM
Breast	71.0 nTPM
Ovary	65.3 nTPM
Adipose tissue	61.2 nTPM
Skeletal muscle	41.2 nTPM
Endometrium	31.5 nTPM
Skin	30.4 nTPM
Esophagus	17.0 nTPM
Prostate	16.2 nTPM
Bronchus	9.5 nTPM
Pancreas	7.4 nTPM

T-cells	2.0 nTPM
Lung	6.1 nTPM
Prostate	4.7 nTPM
Endometrium	4.2 nTPM
Skeletal muscle	4.2 nTPM
Skin	4.1 nTPM
Breast	3.1 nTPM
Kidney	2.7 nTPM
PBMC	1.9 nTPM
Colon	1.0 nTPM
Liver	0.7 nTPM
Adipose tissue	0.6 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Astrocytes	170.4 nTPM
Brain	170.4 nTPM

Cholangiocytes	65.8 nTPM
Liver	65.8 nTPM

Collecting duct cells	23.9 nTPM
Kidney	23.9 nTPM

Cytotrophoblasts	34.7 nTPM
Placenta	34.7 nTPM

Undifferentiated cells	42.0 nTPM
Rectum	67.4 nTPM
Colon	30.5 nTPM
Small intestine	28.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC