Single cell type - EIF2A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2A
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EIF2A is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RSL24D1	Ribosomal L24 domain containing 1	0.6630	32
RPL34	Ribosomal protein L34	0.6588	32
TOMM7	Translocase of outer mitochondrial membrane 7	0.6420	32
RSL1D1	Ribosomal L1 domain containing 1	0.6377	32
RPS3A	Ribosomal protein S3A	0.6298	32
EIF3E	Eukaryotic translation initiation factor 3 subunit E	0.6275	32
RPL14	Ribosomal protein L14	0.6260	32
RPL10	Ribosomal protein L10	0.6254	32
EIF3K	Eukaryotic translation initiation factor 3 subunit K	0.6247	32
RPL6	Ribosomal protein L6	0.6221	32
NACA	Nascent polypeptide associated complex subunit alpha	0.6176	32
RPS13	Ribosomal protein S13	0.6149	32
COMMD6	COMM domain containing 6	0.6135	32
RPS6	Ribosomal protein S6	0.6126	32
RPL9	Ribosomal protein L9	0.6109	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	77.7 nTPM
Adipose tissue	82.6 nTPM
Breast	72.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	67.1 nTPM
Lung	67.1 nTPM

Astrocytes	14.4 nTPM
Brain	14.4 nTPM

B-cells	91.4 nTPM
Breast	112.4 nTPM
Adipose tissue	111.2 nTPM
Spleen	110.8 nTPM
Stomach	92.6 nTPM
Liver	87.8 nTPM
Colon	86.3 nTPM
Lymph node	84.3 nTPM
PBMC	80.0 nTPM
Kidney	76.1 nTPM
Bone marrow	72.7 nTPM

Basal squamous epithelial cells	109.3 nTPM
Esophagus	109.3 nTPM

Dendritic cells	85.7 nTPM
Adipose tissue	92.4 nTPM
PBMC	87.6 nTPM
Breast	76.9 nTPM

Endothelial cells	67.5 nTPM
Skin	110.7 nTPM
Prostate	103.8 nTPM
Liver	95.4 nTPM
Testis	93.7 nTPM
Breast	74.2 nTPM
Pancreas	65.6 nTPM
Lung	65.5 nTPM
Skeletal muscle	57.0 nTPM
Esophagus	56.8 nTPM
Placenta	50.6 nTPM
Endometrium	50.5 nTPM
Heart muscle	48.7 nTPM
Ovary	39.1 nTPM
Eye	34.0 nTPM

Fibroblasts	63.8 nTPM
Lung	93.8 nTPM
Adipose tissue	80.6 nTPM
Skin	73.7 nTPM
Prostate	69.1 nTPM
Placenta	61.4 nTPM
Heart muscle	61.0 nTPM
Stomach	60.9 nTPM
Breast	59.8 nTPM
Skeletal muscle	53.8 nTPM
Esophagus	45.8 nTPM
Ovary	41.8 nTPM

Intestinal goblet cells	81.7 nTPM
Colon	97.9 nTPM
Rectum	89.7 nTPM
Small intestine	57.7 nTPM

Macrophages	72.7 nTPM
Adipose tissue	147.1 nTPM
Testis	120.8 nTPM
Stomach	93.7 nTPM
Lung	88.8 nTPM
Breast	79.4 nTPM
Prostate	74.5 nTPM
Spleen	68.5 nTPM
Endometrium	67.0 nTPM
Skeletal muscle	67.0 nTPM
Ovary	65.7 nTPM
Bone marrow	56.3 nTPM
Pancreas	56.2 nTPM
Kidney	54.4 nTPM
Esophagus	50.4 nTPM
PBMC	0.0 nTPM

Paneth cells	57.7 nTPM
Rectum	85.8 nTPM
Colon	46.1 nTPM
Small intestine	41.3 nTPM

Plasma cells	112.1 nTPM
Stomach	163.9 nTPM
Esophagus	117.0 nTPM
Spleen	107.0 nTPM
Bone marrow	88.9 nTPM
Adipose tissue	83.8 nTPM

Respiratory ciliated cells	41.7 nTPM
Lung	45.2 nTPM
Bronchus	38.2 nTPM

Smooth muscle cells	77.9 nTPM
Prostate	115.4 nTPM
Bronchus	105.3 nTPM
Skin	98.4 nTPM
Breast	88.7 nTPM
Pancreas	79.6 nTPM
Heart muscle	76.4 nTPM
Adipose tissue	74.5 nTPM
Skeletal muscle	61.6 nTPM
Endometrium	54.9 nTPM
Ovary	54.1 nTPM
Esophagus	48.0 nTPM

Cholangiocytes	58.6 nTPM
Liver	58.6 nTPM

Collecting duct cells	35.0 nTPM
Kidney	35.0 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

Cytotrophoblasts	84.1 nTPM
Placenta	84.1 nTPM

T-cells	95.0 nTPM
Prostate	179.9 nTPM
PBMC	149.5 nTPM
Adipose tissue	118.8 nTPM
Lymph node	116.0 nTPM
Skin	107.2 nTPM
Colon	100.7 nTPM
Kidney	100.0 nTPM
Spleen	92.4 nTPM
Breast	89.7 nTPM
Stomach	88.5 nTPM
Ovary	86.7 nTPM
Liver	82.3 nTPM
Lung	77.5 nTPM
Bone marrow	71.1 nTPM
Skeletal muscle	59.4 nTPM
Endometrium	55.5 nTPM
Esophagus	39.3 nTPM

Undifferentiated cells	99.0 nTPM
Small intestine	113.6 nTPM
Colon	93.5 nTPM
Rectum	90.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC