Single cell type - OSBPL11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OSBPL11
Gene descriptionⁱ Full gene name according to HGNC.	Oxysterol binding protein like 11
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes & Neutrophils - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OSBPL11 is part of cluster 19 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SIRPB2	Signal regulatory protein beta 2	0.5745	19
MNDA	Myeloid cell nuclear differentiation antigen	0.5422	19
P2RY13	Purinergic receptor P2Y13	0.5411	19
OSCAR	Osteoclast associated Ig-like receptor	0.5348	19
HPSE	Heparanase	0.5198	19
CLEC6A	C-type lectin domain containing 6A	0.5179	19
IFI30	IFI30 lysosomal thiol reductase	0.5174	19
CYBB	Cytochrome b-245 beta chain	0.5157	19
KDM1B	Lysine demethylase 1B	0.5144	19
TLR8	Toll like receptor 8	0.5117	19
CLEC4A	C-type lectin domain family 4 member A	0.5075	19
JAML	Junction adhesion molecule like	0.5035	19
CTSS	Cathepsin S	0.5023	19
PRAM1	PML-RARA regulated adaptor molecule 1	0.4984	19
NCF2	Neutrophil cytosolic factor 2	0.4968	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.4 nTPM
Breast	16.9 nTPM
Adipose tissue	11.9 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	14.4 nTPM
Lung	14.4 nTPM

Astrocytes	33.3 nTPM
Brain	33.3 nTPM

B-cells	16.0 nTPM
Colon	27.1 nTPM
PBMC	22.8 nTPM
Adipose tissue	22.5 nTPM
Liver	20.6 nTPM
Breast	17.3 nTPM
Lymph node	14.2 nTPM
Spleen	10.0 nTPM
Kidney	9.5 nTPM
Bone marrow	9.0 nTPM
Stomach	7.3 nTPM

Dendritic cells	22.8 nTPM
PBMC	31.8 nTPM
Adipose tissue	19.5 nTPM
Breast	17.1 nTPM

Endothelial cells	9.7 nTPM
Eye	21.0 nTPM
Endometrium	13.3 nTPM
Breast	11.9 nTPM
Skeletal muscle	11.7 nTPM
Liver	11.0 nTPM
Testis	10.6 nTPM
Prostate	10.5 nTPM
Skin	10.2 nTPM
Ovary	9.8 nTPM
Esophagus	7.3 nTPM
Placenta	6.8 nTPM
Heart muscle	4.8 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM

Fibroblasts	9.4 nTPM
Lung	19.0 nTPM
Skeletal muscle	13.5 nTPM
Breast	10.8 nTPM
Adipose tissue	10.6 nTPM
Skin	9.6 nTPM
Prostate	7.8 nTPM
Ovary	7.6 nTPM
Stomach	7.4 nTPM
Placenta	6.2 nTPM
Heart muscle	6.1 nTPM
Esophagus	5.1 nTPM

Intestinal goblet cells	6.0 nTPM
Colon	7.8 nTPM
Rectum	6.1 nTPM
Small intestine	4.2 nTPM

Macrophages	40.3 nTPM
Lung	96.8 nTPM
Esophagus	61.4 nTPM
Bone marrow	57.5 nTPM
Skeletal muscle	50.2 nTPM
Spleen	46.7 nTPM
Testis	45.9 nTPM
Pancreas	40.8 nTPM
Breast	39.9 nTPM
Ovary	36.9 nTPM
Adipose tissue	31.3 nTPM
Kidney	29.5 nTPM
Endometrium	26.6 nTPM
Stomach	23.5 nTPM
Prostate	17.2 nTPM
PBMC	0.0 nTPM

Paneth cells	21.3 nTPM
Colon	39.6 nTPM
Rectum	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	10.5 nTPM
Adipose tissue	17.4 nTPM
Bone marrow	11.5 nTPM
Spleen	9.7 nTPM
Stomach	7.9 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	8.9 nTPM
Lung	10.2 nTPM
Bronchus	7.5 nTPM

Smooth muscle cells	10.5 nTPM
Heart muscle	18.1 nTPM
Endometrium	16.9 nTPM
Breast	14.0 nTPM
Adipose tissue	12.2 nTPM
Skeletal muscle	11.4 nTPM
Ovary	10.0 nTPM
Prostate	9.1 nTPM
Skin	8.3 nTPM
Pancreas	7.8 nTPM
Esophagus	6.2 nTPM
Bronchus	2.0 nTPM

T-cells	11.1 nTPM
Colon	18.1 nTPM
Adipose tissue	18.1 nTPM
PBMC	17.2 nTPM
Skeletal muscle	17.2 nTPM
Breast	17.2 nTPM
Ovary	15.6 nTPM
Endometrium	13.9 nTPM
Liver	12.0 nTPM
Lung	10.6 nTPM
Skin	9.2 nTPM
Kidney	8.2 nTPM
Esophagus	6.6 nTPM
Lymph node	6.4 nTPM
Bone marrow	4.9 nTPM
Prostate	4.7 nTPM
Stomach	4.7 nTPM
Spleen	4.4 nTPM

Basal keratinocytes	9.9 nTPM
Skin	9.9 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Cone photoreceptor cells	12.5 nTPM
Eye	12.5 nTPM

Cytotrophoblasts	12.4 nTPM
Placenta	12.4 nTPM

Undifferentiated cells	9.5 nTPM
Colon	14.8 nTPM
Small intestine	7.2 nTPM
Rectum	6.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC