Single cell type - OCIAD2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OCIAD2
Gene descriptionⁱ Full gene name according to HGNC.	OCIA domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Pancreatic endocrine cells, Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBEC3-KT, U-251 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Pancreatic endocrine cells, Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OCIAD2 is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PDZK1IP1	PDZK1 interacting protein 1	0.7243	67
TPMT	Thiopurine S-methyltransferase	0.7074	67
CLDN2	Claudin 2	0.6693	67
INAVA	Innate immunity activator	0.6549	1
AP1M2	Adaptor related protein complex 1 subunit mu 2	0.6537	67
ADM2	Adrenomedullin 2	0.6527	67
INSC	INSC spindle orientation adaptor protein	0.6463	67
MMP24OS	MMP24 opposite strand	0.6292	7
ATP5MD	ATP synthase membrane subunit DAPIT	0.6212	7
PLCXD2	Phosphatidylinositol specific phospholipase C X domain containing 2	0.6178	7
EIF6	Eukaryotic translation initiation factor 6	0.6131	16
ANXA9	Annexin A9	0.6084	67
MYL12B	Myosin light chain 12B	0.6077	16
AL049629.2	Novel protein	0.6062	16
AC008687.4	Novel protein	0.6041	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	135.9 nTPM
Breast	189.9 nTPM
Adipose tissue	82.0 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	70.6 nTPM
Lung	70.6 nTPM

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	102.5 nTPM
Kidney	233.3 nTPM
PBMC	111.3 nTPM
Colon	110.2 nTPM
Stomach	108.6 nTPM
Lymph node	91.9 nTPM
Breast	85.6 nTPM
Liver	80.5 nTPM
Spleen	77.2 nTPM
Adipose tissue	65.1 nTPM
Bone marrow	61.3 nTPM

Dendritic cells	66.3 nTPM
Breast	94.0 nTPM
Adipose tissue	57.0 nTPM
PBMC	47.8 nTPM

Endothelial cells	103.3 nTPM
Pancreas	374.5 nTPM
Breast	148.8 nTPM
Testis	126.8 nTPM
Heart muscle	109.2 nTPM
Skin	106.0 nTPM
Placenta	104.0 nTPM
Skeletal muscle	92.1 nTPM
Endometrium	80.1 nTPM
Esophagus	78.0 nTPM
Prostate	71.6 nTPM
Liver	53.2 nTPM
Ovary	49.9 nTPM
Eye	36.4 nTPM
Lung	15.6 nTPM

Enteroendocrine cells	306.4 nTPM
Colon	341.1 nTPM
Rectum	271.8 nTPM

Fibroblasts	14.9 nTPM
Ovary	32.8 nTPM
Lung	30.1 nTPM
Heart muscle	24.9 nTPM
Stomach	20.8 nTPM
Skin	16.7 nTPM
Prostate	14.4 nTPM
Breast	12.1 nTPM
Placenta	7.1 nTPM
Esophagus	3.2 nTPM
Skeletal muscle	1.7 nTPM
Adipose tissue	0.2 nTPM

Intestinal goblet cells	301.3 nTPM
Colon	406.7 nTPM
Small intestine	264.4 nTPM
Rectum	232.9 nTPM

Macrophages	21.7 nTPM
Kidney	139.9 nTPM
Breast	39.9 nTPM
Endometrium	32.2 nTPM
Pancreas	20.4 nTPM
Prostate	13.8 nTPM
PBMC	13.6 nTPM
Esophagus	12.6 nTPM
Stomach	11.7 nTPM
Lung	9.9 nTPM
Adipose tissue	7.1 nTPM
Ovary	6.6 nTPM
Testis	5.2 nTPM
Skeletal muscle	5.2 nTPM
Bone marrow	3.7 nTPM
Spleen	3.1 nTPM

Paneth cells	311.6 nTPM
Colon	596.1 nTPM
Rectum	177.1 nTPM
Small intestine	161.5 nTPM

Plasma cells	53.5 nTPM
Stomach	83.2 nTPM
Spleen	68.9 nTPM
Bone marrow	47.7 nTPM
Esophagus	36.9 nTPM
Adipose tissue	31.0 nTPM

Respiratory ciliated cells	171.4 nTPM
Bronchus	262.6 nTPM
Lung	80.2 nTPM

Smooth muscle cells	41.8 nTPM
Bronchus	173.1 nTPM
Ovary	133.8 nTPM
Pancreas	40.4 nTPM
Heart muscle	37.7 nTPM
Prostate	23.5 nTPM
Endometrium	16.8 nTPM
Breast	13.5 nTPM
Skin	12.2 nTPM
Skeletal muscle	5.0 nTPM
Esophagus	3.1 nTPM
Adipose tissue	0.4 nTPM

Basal keratinocytes	109.0 nTPM
Skin	109.0 nTPM

Basal prostatic cells	146.6 nTPM
Prostate	146.6 nTPM

Basal respiratory cells	401.4 nTPM
Bronchus	401.4 nTPM

Basal squamous epithelial cells	81.4 nTPM
Esophagus	81.4 nTPM

T-cells	129.8 nTPM
Kidney	267.0 nTPM
PBMC	183.4 nTPM
Breast	174.6 nTPM
Lymph node	156.7 nTPM
Colon	145.4 nTPM
Ovary	142.3 nTPM
Skin	137.8 nTPM
Liver	132.2 nTPM
Stomach	130.0 nTPM
Endometrium	107.1 nTPM
Spleen	105.1 nTPM
Bone marrow	99.4 nTPM
Esophagus	98.3 nTPM
Lung	94.2 nTPM
Adipose tissue	82.6 nTPM
Prostate	75.7 nTPM
Skeletal muscle	74.4 nTPM

Undifferentiated cells	188.6 nTPM
Small intestine	217.5 nTPM
Colon	176.9 nTPM
Rectum	171.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC