Single cell type - SSBP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SSBP2
Gene descriptionⁱ Full gene name according to HGNC.	Single stranded DNA binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Oligodendrocytes, Microglial cells, Astrocytes, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (JURKAT, MOLT-4, REH)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Oligodendrocytes, Microglial cells, Astrocytes, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SSBP2 is part of cluster 8 Neurons & Oligodendrocytes - Synaptic function with confidenceⁱ 0.99
719 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BICD1	BICD cargo adaptor 1	0.6987	8
MACROD2	Mono-ADP ribosylhydrolase 2	0.6739	8
OCA2	OCA2 melanosomal transmembrane protein	0.6719	8
TRPC7	Transient receptor potential cation channel subfamily C member 7	0.6672	8
XKRX	XK related X-linked	0.6665	8
SPOCK1	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	0.6604	8
HCRTR2	Hypocretin receptor 2	0.6596	8
HIVEP3	HIVEP zinc finger 3	0.6582	8
GRPR	Gastrin releasing peptide receptor	0.6566	8
SH3RF3	SH3 domain containing ring finger 3	0.6564	8
KCNIP1	Potassium voltage-gated channel interacting protein 1	0.6490	8
PRICKLE2	Prickle planar cell polarity protein 2	0.6477	8
EPHA3	EPH receptor A3	0.6425	8
MGAT4C	MGAT4 family member C	0.6412	8
RGS7	Regulator of G protein signaling 7	0.6382	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	43.7 nTPM
Adipose tissue	56.5 nTPM
Breast	31.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	18.6 nTPM
Lung	18.6 nTPM

B-cells	39.0 nTPM
Kidney	71.4 nTPM
Lymph node	50.7 nTPM
PBMC	44.2 nTPM
Spleen	40.5 nTPM
Adipose tissue	38.6 nTPM
Stomach	36.8 nTPM
Bone marrow	34.3 nTPM
Breast	32.1 nTPM
Colon	31.9 nTPM
Liver	9.5 nTPM

Basal keratinocytes	34.9 nTPM
Skin	34.9 nTPM

Basal squamous epithelial cells	122.9 nTPM
Esophagus	122.9 nTPM

Dendritic cells	12.5 nTPM
Adipose tissue	16.9 nTPM
Breast	12.4 nTPM
PBMC	8.0 nTPM

Endothelial cells	21.4 nTPM
Skeletal muscle	35.0 nTPM
Breast	33.1 nTPM
Skin	32.1 nTPM
Heart muscle	30.1 nTPM
Eye	27.5 nTPM
Placenta	26.7 nTPM
Esophagus	23.7 nTPM
Prostate	22.1 nTPM
Testis	20.4 nTPM
Pancreas	19.3 nTPM
Endometrium	11.2 nTPM
Liver	7.3 nTPM
Lung	6.2 nTPM
Ovary	5.2 nTPM

Fibroblasts	48.6 nTPM
Breast	86.2 nTPM
Adipose tissue	77.4 nTPM
Heart muscle	66.1 nTPM
Esophagus	64.8 nTPM
Stomach	53.4 nTPM
Skeletal muscle	53.3 nTPM
Skin	40.7 nTPM
Placenta	31.9 nTPM
Prostate	26.6 nTPM
Ovary	20.9 nTPM
Lung	13.4 nTPM

Intestinal goblet cells	5.4 nTPM
Small intestine	7.6 nTPM
Rectum	5.0 nTPM
Colon	3.6 nTPM

Macrophages	29.9 nTPM
PBMC	95.5 nTPM
Adipose tissue	68.8 nTPM
Testis	50.6 nTPM
Esophagus	33.1 nTPM
Skeletal muscle	29.4 nTPM
Prostate	27.5 nTPM
Ovary	23.6 nTPM
Breast	22.8 nTPM
Bone marrow	22.5 nTPM
Spleen	20.7 nTPM
Kidney	15.2 nTPM
Endometrium	13.0 nTPM
Lung	12.6 nTPM
Stomach	8.8 nTPM
Pancreas	5.1 nTPM

Paneth cells	13.6 nTPM
Small intestine	26.3 nTPM
Rectum	11.3 nTPM
Colon	3.3 nTPM

Plasma cells	14.9 nTPM
Adipose tissue	21.3 nTPM
Stomach	21.3 nTPM
Esophagus	12.3 nTPM
Bone marrow	11.5 nTPM
Spleen	8.1 nTPM

Respiratory ciliated cells	34.1 nTPM
Bronchus	36.0 nTPM
Lung	32.1 nTPM

Smooth muscle cells	59.4 nTPM
Heart muscle	118.6 nTPM
Esophagus	83.7 nTPM
Breast	82.7 nTPM
Skin	81.9 nTPM
Adipose tissue	74.5 nTPM
Prostate	58.8 nTPM
Skeletal muscle	43.1 nTPM
Endometrium	36.7 nTPM
Bronchus	31.7 nTPM
Ovary	23.1 nTPM
Pancreas	18.3 nTPM

Astrocytes	281.7 nTPM
Brain	281.7 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

T-cells	23.9 nTPM
Skin	47.0 nTPM
Lymph node	44.4 nTPM
Prostate	42.6 nTPM
Breast	38.5 nTPM
Adipose tissue	36.9 nTPM
PBMC	25.8 nTPM
Skeletal muscle	24.4 nTPM
Endometrium	21.6 nTPM
Spleen	18.7 nTPM
Colon	16.1 nTPM
Lung	15.2 nTPM
Stomach	13.7 nTPM
Ovary	13.4 nTPM
Kidney	13.1 nTPM
Esophagus	13.1 nTPM
Bone marrow	12.3 nTPM
Liver	9.1 nTPM

Undifferentiated cells	4.4 nTPM
Small intestine	5.4 nTPM
Colon	4.0 nTPM
Rectum	3.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC