Single cell type - DDX46 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDX46
Gene descriptionⁱ Full gene name according to HGNC.	DEAD-box helicase 46
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DDX46 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NOM1	Nucleolar protein with MIF4G domain 1	0.6542	39
REXO4	REX4 homolog, 3'-5' exonuclease	0.5837	39
CBX3	Chromobox 3	0.5829	12
SAFB	Scaffold attachment factor B	0.5824	39
PRPF4B	Pre-mRNA processing factor 4B	0.5651	52
TIMM44	Translocase of inner mitochondrial membrane 44	0.5505	39
BRD7	Bromodomain containing 7	0.5495	52
NOC2L	NOC2 like nucleolar associated transcriptional repressor	0.5494	39
U2SURP	U2 snRNP associated SURP domain containing	0.5447	10
DDX18	DEAD-box helicase 18	0.5341	39
KIAA2026	KIAA2026	0.5334	52
NFATC2IP	Nuclear factor of activated T cells 2 interacting protein	0.5331	52
KNOP1	Lysine rich nucleolar protein 1	0.5292	20
EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.5160	39
ZNHIT6	Zinc finger HIT-type containing 6	0.5139	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	102.4 nTPM
Adipose tissue	106.4 nTPM
Breast	98.4 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	131.5 nTPM
Lung	131.5 nTPM

Astrocytes	35.9 nTPM
Brain	35.9 nTPM

B-cells	123.6 nTPM
Liver	197.6 nTPM
Adipose tissue	146.4 nTPM
PBMC	138.5 nTPM
Colon	135.8 nTPM
Stomach	112.6 nTPM
Spleen	110.8 nTPM
Lymph node	109.4 nTPM
Bone marrow	101.4 nTPM
Breast	97.7 nTPM
Kidney	85.7 nTPM

Dendritic cells	142.3 nTPM
Adipose tissue	205.1 nTPM
Breast	118.0 nTPM
PBMC	103.6 nTPM

Endothelial cells	104.7 nTPM
Prostate	153.7 nTPM
Heart muscle	121.6 nTPM
Ovary	121.1 nTPM
Skeletal muscle	116.6 nTPM
Lung	115.4 nTPM
Placenta	110.2 nTPM
Endometrium	109.0 nTPM
Testis	102.9 nTPM
Pancreas	100.4 nTPM
Breast	98.4 nTPM
Skin	92.6 nTPM
Esophagus	83.5 nTPM
Eye	72.8 nTPM
Liver	67.8 nTPM

Fibroblasts	85.1 nTPM
Lung	131.8 nTPM
Ovary	106.4 nTPM
Prostate	102.8 nTPM
Placenta	93.7 nTPM
Adipose tissue	86.5 nTPM
Breast	83.8 nTPM
Skeletal muscle	75.6 nTPM
Skin	74.6 nTPM
Esophagus	66.2 nTPM
Stomach	63.9 nTPM
Heart muscle	50.6 nTPM

Intestinal goblet cells	112.4 nTPM
Colon	186.5 nTPM
Small intestine	78.8 nTPM
Rectum	72.0 nTPM

Macrophages	103.4 nTPM
Adipose tissue	148.6 nTPM
Lung	145.7 nTPM
Testis	144.7 nTPM
Kidney	133.0 nTPM
Endometrium	127.1 nTPM
Skeletal muscle	111.6 nTPM
Spleen	102.7 nTPM
Prostate	91.7 nTPM
Breast	90.2 nTPM
Esophagus	89.7 nTPM
Pancreas	89.3 nTPM
Stomach	88.0 nTPM
Bone marrow	81.2 nTPM
Ovary	80.8 nTPM
PBMC	27.3 nTPM

Paneth cells	62.6 nTPM
Rectum	68.5 nTPM
Small intestine	60.1 nTPM
Colon	59.3 nTPM

Plasma cells	134.7 nTPM
Adipose tissue	172.9 nTPM
Spleen	152.5 nTPM
Bone marrow	126.9 nTPM
Esophagus	117.0 nTPM
Stomach	104.0 nTPM

Respiratory ciliated cells	74.5 nTPM
Lung	84.5 nTPM
Bronchus	64.5 nTPM

Smooth muscle cells	115.2 nTPM
Ovary	159.8 nTPM
Heart muscle	147.8 nTPM
Endometrium	123.8 nTPM
Skeletal muscle	123.2 nTPM
Esophagus	122.5 nTPM
Pancreas	117.2 nTPM
Adipose tissue	112.0 nTPM
Prostate	110.0 nTPM
Skin	85.8 nTPM
Bronchus	85.6 nTPM
Breast	80.1 nTPM

T-cells	131.8 nTPM
Adipose tissue	199.4 nTPM
PBMC	191.1 nTPM
Colon	177.2 nTPM
Skeletal muscle	159.5 nTPM
Endometrium	156.7 nTPM
Liver	146.1 nTPM
Lung	145.8 nTPM
Prostate	132.5 nTPM
Kidney	123.9 nTPM
Skin	122.1 nTPM
Breast	105.6 nTPM
Stomach	104.0 nTPM
Bone marrow	102.8 nTPM
Lymph node	100.6 nTPM
Ovary	97.9 nTPM
Spleen	96.1 nTPM
Esophagus	78.6 nTPM

Basal keratinocytes	113.8 nTPM
Skin	113.8 nTPM

Basal prostatic cells	121.5 nTPM
Prostate	121.5 nTPM

Basal squamous epithelial cells	68.9 nTPM
Esophagus	68.9 nTPM

Cholangiocytes	64.3 nTPM
Liver	64.3 nTPM

Undifferentiated cells	112.7 nTPM
Colon	166.6 nTPM
Small intestine	94.2 nTPM
Rectum	77.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC