Single cell type - FAM193B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM193B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 193 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Nuclear processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM193B is part of cluster 43 Cardiomyocytes - Nuclear processes with confidenceⁱ 1
192 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CRYGS	Crystallin gamma S	0.6457	43
MBD3L3	Methyl-CpG binding domain protein 3 like 3	0.6222	43
SCART1	Scavenger receptor family member expressed on T cells 1	0.5778	43
TUBGCP6	Tubulin gamma complex associated protein 6	0.5553	52
GPR101	G protein-coupled receptor 101	0.5514	43
RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like	0.5338	43
H4C12	H4 clustered histone 12	0.5302	43
NTN3	Netrin 3	0.5301	43
ANKRD20A2P	Ankyrin repeat domain 20 family member A2, pseudogene	0.5297	43
TMC3	Transmembrane channel like 3	0.5296	43
MBD3L2	Methyl-CpG binding domain protein 3 like 2	0.5232	43
GDF2	Growth differentiation factor 2	0.5217	43
HOXD12	Homeobox D12	0.5172	43
GSX2	GS homeobox 2	0.5123	43
CRACD	Capping protein inhibiting regulator of actin dynamics	0.5116	43

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.9 nTPM
Breast	19.2 nTPM
Adipose tissue	14.6 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	26.7 nTPM
Lung	26.7 nTPM

Astrocytes	45.1 nTPM
Brain	45.1 nTPM

B-cells	8.5 nTPM
Breast	16.0 nTPM
Bone marrow	12.3 nTPM
Lymph node	10.5 nTPM
Colon	8.0 nTPM
Adipose tissue	7.5 nTPM
Stomach	6.8 nTPM
Liver	6.7 nTPM
Spleen	6.2 nTPM
PBMC	5.7 nTPM
Kidney	4.8 nTPM

Dendritic cells	11.9 nTPM
Breast	20.0 nTPM
Adipose tissue	11.8 nTPM
PBMC	4.0 nTPM

Endothelial cells	12.5 nTPM
Heart muscle	31.1 nTPM
Breast	18.5 nTPM
Skeletal muscle	18.1 nTPM
Eye	15.4 nTPM
Ovary	14.8 nTPM
Endometrium	13.2 nTPM
Placenta	11.9 nTPM
Skin	10.9 nTPM
Testis	9.8 nTPM
Lung	9.3 nTPM
Prostate	8.9 nTPM
Esophagus	8.3 nTPM
Liver	5.5 nTPM
Pancreas	0.0 nTPM

Fibroblasts	11.7 nTPM
Heart muscle	23.1 nTPM
Breast	19.1 nTPM
Skeletal muscle	13.7 nTPM
Stomach	11.9 nTPM
Esophagus	11.7 nTPM
Skin	10.6 nTPM
Adipose tissue	10.2 nTPM
Ovary	9.9 nTPM
Lung	8.9 nTPM
Placenta	6.9 nTPM
Prostate	2.9 nTPM

Intestinal goblet cells	15.6 nTPM
Rectum	18.4 nTPM
Colon	15.7 nTPM
Small intestine	12.6 nTPM

Macrophages	10.6 nTPM
Esophagus	23.6 nTPM
Breast	16.7 nTPM
Bone marrow	15.0 nTPM
Spleen	14.5 nTPM
Lung	14.4 nTPM
Skeletal muscle	13.7 nTPM
Stomach	11.7 nTPM
Ovary	11.6 nTPM
Adipose tissue	10.0 nTPM
Prostate	9.1 nTPM
Endometrium	8.5 nTPM
Kidney	4.6 nTPM
Pancreas	2.5 nTPM
Testis	2.3 nTPM
PBMC	0.0 nTPM

Paneth cells	8.4 nTPM
Rectum	14.9 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	6.9 nTPM
Adipose tissue	18.1 nTPM
Spleen	7.8 nTPM
Stomach	6.8 nTPM
Bone marrow	1.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.7 nTPM
Bronchus	12.7 nTPM
Lung	8.7 nTPM

Smooth muscle cells	11.1 nTPM
Breast	22.0 nTPM
Adipose tissue	14.9 nTPM
Endometrium	13.2 nTPM
Skeletal muscle	13.2 nTPM
Ovary	12.4 nTPM
Skin	12.1 nTPM
Heart muscle	11.5 nTPM
Esophagus	9.3 nTPM
Prostate	4.7 nTPM
Bronchus	4.7 nTPM
Pancreas	3.5 nTPM

T-cells	10.4 nTPM
Breast	22.2 nTPM
Lung	21.3 nTPM
Ovary	17.8 nTPM
Skeletal muscle	17.2 nTPM
Endometrium	15.6 nTPM
Adipose tissue	11.8 nTPM
Liver	10.6 nTPM
Lymph node	10.5 nTPM
Skin	8.8 nTPM
Colon	7.1 nTPM
PBMC	7.0 nTPM
Esophagus	6.6 nTPM
Bone marrow	6.1 nTPM
Kidney	5.5 nTPM
Spleen	5.4 nTPM
Stomach	3.2 nTPM
Prostate	0.0 nTPM

Basal prostatic cells	5.8 nTPM
Prostate	5.8 nTPM

Basal respiratory cells	7.2 nTPM
Bronchus	7.2 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Undifferentiated cells	11.7 nTPM
Colon	12.2 nTPM
Rectum	11.9 nTPM
Small intestine	11.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC