Single cell type - PRPS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRPS1
Gene descriptionⁱ Full gene name according to HGNC.	Phosphoribosyl pyrophosphate synthetase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRPS1 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.5629	24
LPXN	Leupaxin	0.5513	58
IL21R	Interleukin 21 receptor	0.5414	24
IL17A	Interleukin 17A	0.5401	24
P2RY10	P2Y receptor family member 10	0.5374	24
TRBV28	T cell receptor beta variable 28	0.5353	24
PDCD1	Programmed cell death 1	0.5335	24
G3BP1	G3BP stress granule assembly factor 1	0.5333	28
SC5D	Sterol-C5-desaturase	0.5266	15
CCR6	C-C motif chemokine receptor 6	0.5175	24
IL9R	Interleukin 9 receptor	0.5167	58
IL4	Interleukin 4	0.5127	24
SARDH	Sarcosine dehydrogenase	0.5120	67
RHOH	Ras homolog family member H	0.5120	24
IL22	Interleukin 22	0.5104	58

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.0 nTPM
Adipose tissue	24.4 nTPM
Breast	17.5 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	10.0 nTPM
Lung	10.0 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	44.2 nTPM
Stomach	60.9 nTPM
Liver	55.3 nTPM
Kidney	52.4 nTPM
Bone marrow	50.7 nTPM
Lymph node	50.2 nTPM
Adipose tissue	50.1 nTPM
Spleen	48.4 nTPM
Colon	36.7 nTPM
Breast	21.3 nTPM
PBMC	15.7 nTPM

Dendritic cells	29.3 nTPM
Adipose tissue	41.9 nTPM
Breast	33.9 nTPM
PBMC	12.0 nTPM

Endothelial cells	18.1 nTPM
Prostate	38.5 nTPM
Skin	34.7 nTPM
Pancreas	23.1 nTPM
Skeletal muscle	21.9 nTPM
Liver	19.2 nTPM
Ovary	18.2 nTPM
Esophagus	17.4 nTPM
Endometrium	17.2 nTPM
Breast	15.7 nTPM
Testis	13.3 nTPM
Placenta	13.1 nTPM
Eye	8.1 nTPM
Heart muscle	6.6 nTPM
Lung	6.2 nTPM

Fibroblasts	22.2 nTPM
Prostate	45.6 nTPM
Stomach	31.2 nTPM
Skin	31.0 nTPM
Adipose tissue	25.8 nTPM
Ovary	20.8 nTPM
Skeletal muscle	17.3 nTPM
Placenta	16.9 nTPM
Esophagus	16.1 nTPM
Heart muscle	15.3 nTPM
Breast	13.6 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	6.5 nTPM
Rectum	8.0 nTPM
Small intestine	7.1 nTPM
Colon	4.3 nTPM

Macrophages	16.8 nTPM
Adipose tissue	30.1 nTPM
Kidney	25.7 nTPM
Pancreas	23.0 nTPM
Bone marrow	21.2 nTPM
Breast	20.3 nTPM
Spleen	19.7 nTPM
Testis	18.6 nTPM
Ovary	18.0 nTPM
Esophagus	17.3 nTPM
Skeletal muscle	16.9 nTPM
Endometrium	14.0 nTPM
Lung	13.8 nTPM
Prostate	10.3 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	3.7 nTPM
Rectum	4.0 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	35.7 nTPM
Spleen	53.3 nTPM
Bone marrow	41.2 nTPM
Stomach	36.8 nTPM
Esophagus	24.6 nTPM
Adipose tissue	22.5 nTPM

Respiratory ciliated cells	27.1 nTPM
Lung	33.5 nTPM
Bronchus	20.6 nTPM

Smooth muscle cells	30.7 nTPM
Pancreas	96.9 nTPM
Skin	50.9 nTPM
Prostate	45.6 nTPM
Esophagus	29.4 nTPM
Skeletal muscle	22.8 nTPM
Adipose tissue	22.4 nTPM
Breast	20.3 nTPM
Bronchus	17.2 nTPM
Ovary	14.7 nTPM
Endometrium	10.9 nTPM
Heart muscle	7.2 nTPM

T-cells	45.0 nTPM
Adipose tissue	70.0 nTPM
Skin	65.4 nTPM
Stomach	64.8 nTPM
Kidney	58.9 nTPM
Lymph node	57.9 nTPM
Spleen	55.4 nTPM
Colon	54.2 nTPM
Bone marrow	49.2 nTPM
Ovary	48.9 nTPM
Breast	47.0 nTPM
Liver	41.0 nTPM
Skeletal muscle	35.5 nTPM
Esophagus	32.8 nTPM
Endometrium	24.3 nTPM
PBMC	23.4 nTPM
Prostate	19.0 nTPM
Lung	16.7 nTPM

Basal keratinocytes	31.1 nTPM
Skin	31.1 nTPM

Basal prostatic cells	18.4 nTPM
Prostate	18.4 nTPM

Basal respiratory cells	13.2 nTPM
Bronchus	13.2 nTPM

Collecting duct cells	16.5 nTPM
Kidney	16.5 nTPM

Undifferentiated cells	8.0 nTPM
Colon	9.5 nTPM
Rectum	7.2 nTPM
Small intestine	7.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC