Single cell type - DOCK11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DOCK11
Gene descriptionⁱ Full gene name according to HGNC.	Dedicator of cytokinesis 11
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Microglial cells, NK-cells, Kupffer cells, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Microglial cells, NK-cells, Kupffer cells, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DOCK11 is part of cluster 8 Neurons & Oligodendrocytes - Synaptic function with confidenceⁱ 1
719 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NCALD	Neurocalcin delta	0.5954	8
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	0.5845	8
BTBD11	BTB domain containing 11	0.5779	8
MANBA	Mannosidase beta	0.5679	57
ZMAT4	Zinc finger matrin-type 4	0.5657	8
NCOA2	Nuclear receptor coactivator 2	0.5644	8
ERBB4	Erb-b2 receptor tyrosine kinase 4	0.5633	8
PPIP5K2	Diphosphoinositol pentakisphosphate kinase 2	0.5538	8
TRPC4	Transient receptor potential cation channel subfamily C member 4	0.5466	8
DLGAP1	DLG associated protein 1	0.5451	8
ADCY8	Adenylate cyclase 8	0.5433	8
SLIT2	Slit guidance ligand 2	0.5372	8
CACNG2	Calcium voltage-gated channel auxiliary subunit gamma 2	0.5372	8
SLC9A9	Solute carrier family 9 member A9	0.5360	8
PLXNC1	Plexin C1	0.5343	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.9 nTPM
Adipose tissue	13.0 nTPM
Breast	8.7 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	3.7 nTPM
Lung	3.7 nTPM

Astrocytes	6.8 nTPM
Brain	6.8 nTPM

B-cells	38.3 nTPM
Adipose tissue	66.2 nTPM
Bone marrow	65.4 nTPM
Spleen	49.5 nTPM
Lymph node	43.5 nTPM
Kidney	38.1 nTPM
Stomach	34.1 nTPM
Colon	27.1 nTPM
PBMC	27.1 nTPM
Breast	20.0 nTPM
Liver	11.6 nTPM

Dendritic cells	34.5 nTPM
Adipose tissue	58.9 nTPM
Breast	40.5 nTPM
PBMC	4.0 nTPM

Endothelial cells	7.4 nTPM
Esophagus	25.3 nTPM
Skin	21.6 nTPM
Breast	14.6 nTPM
Prostate	13.1 nTPM
Eye	10.5 nTPM
Skeletal muscle	9.8 nTPM
Lung	3.1 nTPM
Heart muscle	2.1 nTPM
Placenta	1.1 nTPM
Testis	1.1 nTPM
Endometrium	0.8 nTPM
Ovary	0.2 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	18.7 nTPM
Lung	62.6 nTPM
Adipose tissue	46.5 nTPM
Skeletal muscle	33.1 nTPM
Skin	17.2 nTPM
Stomach	11.9 nTPM
Breast	9.7 nTPM
Placenta	8.7 nTPM
Esophagus	8.2 nTPM
Heart muscle	3.8 nTPM
Prostate	2.7 nTPM
Ovary	1.5 nTPM

Intestinal goblet cells	3.2 nTPM
Rectum	4.9 nTPM
Small intestine	2.4 nTPM
Colon	2.2 nTPM

Macrophages	45.7 nTPM
Stomach	82.1 nTPM
Adipose tissue	76.5 nTPM
Skeletal muscle	69.0 nTPM
Spleen	64.3 nTPM
Testis	63.9 nTPM
Bone marrow	60.0 nTPM
Lung	57.6 nTPM
Ovary	56.6 nTPM
Esophagus	34.6 nTPM
Kidney	34.0 nTPM
Endometrium	28.7 nTPM
Breast	23.9 nTPM
Prostate	18.4 nTPM
Pancreas	15.3 nTPM
PBMC	0.0 nTPM

Paneth cells	1.5 nTPM
Small intestine	3.7 nTPM
Rectum	0.9 nTPM
Colon	0.0 nTPM

Plasma cells	22.7 nTPM
Adipose tissue	44.6 nTPM
Bone marrow	24.7 nTPM
Spleen	19.2 nTPM
Stomach	19.0 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	1.2 nTPM
Lung	1.5 nTPM
Bronchus	1.0 nTPM

Smooth muscle cells	14.0 nTPM
Adipose tissue	39.4 nTPM
Skeletal muscle	27.6 nTPM
Breast	20.5 nTPM
Skin	14.6 nTPM
Esophagus	12.4 nTPM
Heart muscle	10.0 nTPM
Endometrium	7.9 nTPM
Prostate	7.5 nTPM
Bronchus	6.6 nTPM
Ovary	4.6 nTPM
Pancreas	3.5 nTPM

T-cells	36.6 nTPM
Skeletal muscle	67.7 nTPM
Adipose tissue	60.1 nTPM
Bone marrow	59.3 nTPM
Spleen	46.6 nTPM
Ovary	44.5 nTPM
PBMC	41.8 nTPM
Lymph node	41.4 nTPM
Stomach	36.3 nTPM
Endometrium	32.2 nTPM
Liver	31.3 nTPM
Breast	30.7 nTPM
Colon	27.1 nTPM
Skin	26.2 nTPM
Kidney	26.0 nTPM
Lung	19.7 nTPM
Prostate	19.0 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	2.9 nTPM
Skin	2.9 nTPM

Basal prostatic cells	0.1 nTPM
Prostate	0.1 nTPM

Basal respiratory cells	0.4 nTPM
Bronchus	0.4 nTPM

Basal squamous epithelial cells	0.6 nTPM
Esophagus	0.6 nTPM

Undifferentiated cells	1.3 nTPM
Small intestine	2.7 nTPM
Rectum	0.9 nTPM
Colon	0.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC