Single cell type - SLC25A37 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A37
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 37
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells, Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells, Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC25A37 is part of cluster 6 Erythroid cells - Oxygen transport with confidenceⁱ 1
151 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HBA1	Hemoglobin subunit alpha 1	0.8807	6
AHSP	Alpha hemoglobin stabilizing protein	0.8805	6
HBB	Hemoglobin subunit beta	0.8801	6
HBD	Hemoglobin subunit delta	0.8798	6
HBA2	Hemoglobin subunit alpha 2	0.8787	6
ALAS2	5'-aminolevulinate synthase 2	0.8786	6
HBM	Hemoglobin subunit mu	0.8779	6
EPB42	Erythrocyte membrane protein band 4.2	0.8769	6
RHCE	Rh blood group CcEe antigens	0.8769	6
IFIT1B	Interferon induced protein with tetratricopeptide repeats 1B	0.8768	6
TSPO2	Translocator protein 2	0.8761	6
GYPB	Glycophorin B (MNS blood group)	0.8759	6
HBQ1	Hemoglobin subunit theta 1	0.8752	6
GYPA	Glycophorin A (MNS blood group)	0.8743	6
TRIM58	Tripartite motif containing 58	0.8725	6

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	43.5 nTPM
Adipose tissue	45.5 nTPM
Breast	41.4 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	61.7 nTPM
Lung	61.7 nTPM

Astrocytes	36.6 nTPM
Brain	36.6 nTPM

B-cells	45.5 nTPM
Bone marrow	63.0 nTPM
Kidney	57.1 nTPM
Colon	52.7 nTPM
Adipose tissue	50.1 nTPM
PBMC	47.1 nTPM
Breast	45.4 nTPM
Spleen	40.8 nTPM
Liver	36.4 nTPM
Lymph node	33.3 nTPM
Stomach	28.6 nTPM

Dendritic cells	19.1 nTPM
Breast	25.9 nTPM
Adipose tissue	19.5 nTPM
PBMC	12.0 nTPM

Endothelial cells	94.5 nTPM
Prostate	284.6 nTPM
Liver	182.5 nTPM
Skin	153.9 nTPM
Eye	127.8 nTPM
Skeletal muscle	92.2 nTPM
Pancreas	88.8 nTPM
Endometrium	69.6 nTPM
Lung	59.3 nTPM
Breast	51.1 nTPM
Esophagus	49.0 nTPM
Placenta	47.2 nTPM
Ovary	45.7 nTPM
Heart muscle	44.4 nTPM
Testis	27.2 nTPM

Erythroid cells	4197.2 nTPM
Liver	7835.2 nTPM
Bone marrow	559.1 nTPM

Fibroblasts	95.4 nTPM
Prostate	316.4 nTPM
Lung	184.3 nTPM
Skin	149.0 nTPM
Ovary	81.9 nTPM
Skeletal muscle	60.4 nTPM
Breast	49.1 nTPM
Esophagus	47.4 nTPM
Placenta	45.0 nTPM
Adipose tissue	43.9 nTPM
Stomach	40.1 nTPM
Heart muscle	32.5 nTPM

Intestinal goblet cells	44.7 nTPM
Small intestine	67.0 nTPM
Colon	35.1 nTPM
Rectum	32.1 nTPM

Macrophages	86.8 nTPM
Skeletal muscle	206.5 nTPM
Adipose tissue	162.0 nTPM
Prostate	149.0 nTPM
Testis	140.6 nTPM
Stomach	111.3 nTPM
Spleen	97.4 nTPM
Lung	86.8 nTPM
Kidney	82.4 nTPM
Endometrium	68.0 nTPM
Esophagus	62.9 nTPM
Bone marrow	42.5 nTPM
Breast	38.3 nTPM
Ovary	33.4 nTPM
PBMC	13.6 nTPM
Pancreas	7.7 nTPM

Paneth cells	47.7 nTPM
Small intestine	71.4 nTPM
Colon	39.6 nTPM
Rectum	32.1 nTPM

Plasma cells	24.0 nTPM
Adipose tissue	34.2 nTPM
Esophagus	30.7 nTPM
Bone marrow	29.7 nTPM
Spleen	20.2 nTPM
Stomach	5.4 nTPM

Respiratory ciliated cells	42.5 nTPM
Bronchus	61.7 nTPM
Lung	23.3 nTPM

Smooth muscle cells	52.3 nTPM
Skin	121.4 nTPM
Prostate	107.5 nTPM
Ovary	76.8 nTPM
Skeletal muscle	52.2 nTPM
Pancreas	47.8 nTPM
Endometrium	42.6 nTPM
Breast	33.8 nTPM
Adipose tissue	30.9 nTPM
Heart muscle	22.3 nTPM
Bronchus	21.6 nTPM
Esophagus	18.6 nTPM

Basal keratinocytes	93.3 nTPM
Skin	93.3 nTPM

Basal prostatic cells	125.2 nTPM
Prostate	125.2 nTPM

Basal respiratory cells	95.8 nTPM
Bronchus	95.8 nTPM

Basal squamous epithelial cells	28.5 nTPM
Esophagus	28.5 nTPM

T-cells	32.4 nTPM
Skin	68.2 nTPM
Lung	50.1 nTPM
Prostate	47.3 nTPM
Breast	47.3 nTPM
Skeletal muscle	44.0 nTPM
Adipose tissue	37.5 nTPM
Bone marrow	33.1 nTPM
PBMC	33.0 nTPM
Ovary	31.1 nTPM
Kidney	25.3 nTPM
Colon	24.7 nTPM
Lymph node	24.6 nTPM
Endometrium	21.4 nTPM
Spleen	20.4 nTPM
Liver	19.6 nTPM
Stomach	16.0 nTPM
Esophagus	6.6 nTPM

Undifferentiated cells	70.3 nTPM
Colon	83.1 nTPM
Small intestine	81.9 nTPM
Rectum	46.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC