Single cell type - PLPP5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLPP5
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipid phosphatase 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Plasma cells, Prostatic glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive B-cell, memory B-cell, basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Plasma cells, Prostatic glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLPP5 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 1
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TXNDC11	Thioredoxin domain containing 11	0.7082	55
IGLV1-44	Immunoglobulin lambda variable 1-44	0.6854	55
IGLV5-45	Immunoglobulin lambda variable 5-45	0.6835	55
SEC11C	SEC11 homolog C, signal peptidase complex subunit	0.6834	55
IGLV3-9	Immunoglobulin lambda variable 3-9	0.6796	55
IGLV3-19	Immunoglobulin lambda variable 3-19	0.6757	55
IGLV3-25	Immunoglobulin lambda variable 3-25	0.6757	55
IGLV3-27	Immunoglobulin lambda variable 3-27	0.6753	55
IGHV1-2	Immunoglobulin heavy variable 1-2	0.6738	55
IGLV4-69	Immunoglobulin lambda variable 4-69	0.6732	55
IGLV3-21	Immunoglobulin lambda variable 3-21	0.6727	55
FKBP11	FKBP prolyl isomerase 11	0.6707	55
IGHV3-33	Immunoglobulin heavy variable 3-33	0.6685	55
IGLV2-8	Immunoglobulin lambda variable 2-8	0.6672	55
IGLV5-48	Immunoglobulin lambda variable 5-48 (non-functional)	0.6670	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.2 nTPM
Breast	22.5 nTPM
Adipose tissue	21.9 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	46.2 nTPM
Lung	46.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	110.8 nTPM
PBMC	305.4 nTPM
Liver	226.6 nTPM
Breast	216.7 nTPM
Kidney	100.0 nTPM
Adipose tissue	77.7 nTPM
Bone marrow	63.0 nTPM
Spleen	47.1 nTPM
Lymph node	39.2 nTPM
Stomach	32.2 nTPM
Colon	0.0 nTPM

Dendritic cells	14.8 nTPM
Breast	25.9 nTPM
Adipose tissue	18.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	27.9 nTPM
Prostate	68.4 nTPM
Lung	53.0 nTPM
Pancreas	50.2 nTPM
Esophagus	35.0 nTPM
Endometrium	31.8 nTPM
Testis	28.5 nTPM
Ovary	28.3 nTPM
Placenta	24.5 nTPM
Breast	23.8 nTPM
Skeletal muscle	17.1 nTPM
Liver	15.6 nTPM
Eye	13.7 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM

Fibroblasts	41.5 nTPM
Lung	124.0 nTPM
Prostate	61.9 nTPM
Stomach	52.0 nTPM
Placenta	50.7 nTPM
Esophagus	48.5 nTPM
Breast	38.4 nTPM
Adipose tissue	29.3 nTPM
Skeletal muscle	25.7 nTPM
Ovary	25.7 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	62.6 nTPM
Small intestine	106.0 nTPM
Rectum	81.8 nTPM
Colon	0.0 nTPM

Macrophages	23.0 nTPM
Pancreas	56.2 nTPM
Lung	32.7 nTPM
Bone marrow	30.0 nTPM
Prostate	29.8 nTPM
PBMC	27.3 nTPM
Ovary	25.6 nTPM
Breast	25.1 nTPM
Kidney	24.9 nTPM
Endometrium	19.1 nTPM
Adipose tissue	19.0 nTPM
Skeletal muscle	15.5 nTPM
Testis	11.7 nTPM
Stomach	11.7 nTPM
Spleen	9.3 nTPM
Esophagus	7.9 nTPM

Paneth cells	31.1 nTPM
Small intestine	52.6 nTPM
Rectum	40.6 nTPM
Colon	0.0 nTPM

Plasma cells	264.5 nTPM
Stomach	497.6 nTPM
Esophagus	307.9 nTPM
Spleen	246.8 nTPM
Bone marrow	163.2 nTPM
Adipose tissue	107.1 nTPM

Respiratory ciliated cells	55.4 nTPM
Lung	110.8 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	18.9 nTPM
Pancreas	49.5 nTPM
Ovary	39.8 nTPM
Prostate	34.7 nTPM
Endometrium	20.5 nTPM
Breast	20.5 nTPM
Skeletal muscle	14.9 nTPM
Adipose tissue	14.5 nTPM
Esophagus	14.0 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	25.2 nTPM
Prostate	94.7 nTPM
Lung	48.6 nTPM
Breast	35.8 nTPM
Ovary	31.1 nTPM
Adipose tissue	26.0 nTPM
Stomach	25.5 nTPM
Kidney	22.6 nTPM
Endometrium	22.3 nTPM
Liver	19.9 nTPM
Spleen	19.2 nTPM
Skeletal muscle	18.7 nTPM
Bone marrow	18.3 nTPM
Lymph node	17.3 nTPM
PBMC	15.4 nTPM
Esophagus	13.1 nTPM
Colon	0.0 nTPM
Skin	0.0 nTPM

Cholangiocytes	32.9 nTPM
Liver	32.9 nTPM

Collecting duct cells	75.4 nTPM
Kidney	75.4 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Cytotrophoblasts	45.1 nTPM
Placenta	45.1 nTPM

Undifferentiated cells	44.1 nTPM
Small intestine	72.0 nTPM
Rectum	60.2 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC