Single cell type - TATDN1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TATDN1
Gene descriptionⁱ Full gene name according to HGNC.	TatD DNase domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TATDN1 is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFS4	NADH:ubiquinone oxidoreductase subunit S4	0.6462	39
BTF3	Basic transcription factor 3	0.6201	32
NACA	Nascent polypeptide associated complex subunit alpha	0.6126	32
RPL3	Ribosomal protein L3	0.6046	32
RPS4X	Ribosomal protein S4 X-linked	0.5825	32
ZFAND1	Zinc finger AN1-type containing 1	0.5727	32
EIF3E	Eukaryotic translation initiation factor 3 subunit E	0.5595	32
RPS18	Ribosomal protein S18	0.5589	32
RPL7	Ribosomal protein L7	0.5566	32
RPS6	Ribosomal protein S6	0.5484	32
RPS3A	Ribosomal protein S3A	0.5447	32
HINT1	Histidine triad nucleotide binding protein 1	0.5437	32
RPS9	Ribosomal protein S9	0.5429	32
RPL15	Ribosomal protein L15	0.5406	32
SH3YL1	SH3 and SYLF domain containing 1	0.5371	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	39.8 nTPM
Breast	43.4 nTPM
Adipose tissue	36.1 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	27.1 nTPM
Lung	27.1 nTPM

Astrocytes	25.5 nTPM
Brain	25.5 nTPM

B-cells	37.0 nTPM
Kidney	42.9 nTPM
Spleen	42.9 nTPM
Lymph node	40.3 nTPM
Bone marrow	39.2 nTPM
Liver	38.4 nTPM
Stomach	37.7 nTPM
Breast	33.4 nTPM
Colon	31.9 nTPM
PBMC	31.5 nTPM
Adipose tissue	31.5 nTPM

Dendritic cells	26.7 nTPM
PBMC	31.8 nTPM
Breast	28.1 nTPM
Adipose tissue	20.3 nTPM

Endothelial cells	31.9 nTPM
Pancreas	54.0 nTPM
Skin	52.2 nTPM
Prostate	47.5 nTPM
Breast	45.8 nTPM
Testis	42.4 nTPM
Esophagus	31.4 nTPM
Placenta	30.1 nTPM
Eye	26.7 nTPM
Skeletal muscle	25.6 nTPM
Endometrium	23.6 nTPM
Liver	22.0 nTPM
Ovary	20.6 nTPM
Lung	15.6 nTPM
Heart muscle	9.3 nTPM

Fibroblasts	42.7 nTPM
Adipose tissue	66.8 nTPM
Prostate	52.6 nTPM
Breast	51.8 nTPM
Ovary	50.7 nTPM
Skin	49.9 nTPM
Lung	48.0 nTPM
Placenta	45.2 nTPM
Skeletal muscle	34.0 nTPM
Esophagus	33.5 nTPM
Stomach	25.3 nTPM
Heart muscle	11.9 nTPM

Intestinal goblet cells	41.6 nTPM
Rectum	55.8 nTPM
Small intestine	35.6 nTPM
Colon	33.6 nTPM

Macrophages	36.3 nTPM
Testis	74.4 nTPM
Prostate	68.8 nTPM
Kidney	50.6 nTPM
Breast	43.9 nTPM
Esophagus	40.9 nTPM
Adipose tissue	39.3 nTPM
Endometrium	35.6 nTPM
Ovary	33.4 nTPM
Lung	31.8 nTPM
Spleen	30.0 nTPM
Skeletal muscle	26.4 nTPM
Stomach	26.4 nTPM
Pancreas	23.0 nTPM
Bone marrow	20.0 nTPM
PBMC	0.0 nTPM

Paneth cells	34.3 nTPM
Rectum	66.5 nTPM
Small intestine	26.3 nTPM
Colon	9.9 nTPM

Plasma cells	34.1 nTPM
Spleen	44.3 nTPM
Esophagus	43.0 nTPM
Stomach	37.3 nTPM
Adipose tissue	24.5 nTPM
Bone marrow	21.4 nTPM

Respiratory ciliated cells	33.8 nTPM
Bronchus	42.9 nTPM
Lung	24.8 nTPM

Smooth muscle cells	57.5 nTPM
Bronchus	191.8 nTPM
Prostate	70.0 nTPM
Pancreas	54.9 nTPM
Skin	48.8 nTPM
Adipose tissue	48.7 nTPM
Ovary	48.1 nTPM
Breast	46.8 nTPM
Esophagus	44.9 nTPM
Endometrium	35.8 nTPM
Skeletal muscle	33.0 nTPM
Heart muscle	9.3 nTPM

T-cells	38.9 nTPM
Prostate	71.1 nTPM
Lymph node	65.2 nTPM
PBMC	56.1 nTPM
Spleen	45.3 nTPM
Kidney	42.4 nTPM
Liver	42.3 nTPM
Colon	35.6 nTPM
Ovary	35.6 nTPM
Stomach	35.5 nTPM
Breast	35.5 nTPM
Skin	35.4 nTPM
Bone marrow	34.9 nTPM
Adipose tissue	31.2 nTPM
Endometrium	30.5 nTPM
Skeletal muscle	25.4 nTPM
Lung	19.7 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	64.7 nTPM
Skin	64.7 nTPM

Basal prostatic cells	100.9 nTPM
Prostate	100.9 nTPM

Basal respiratory cells	129.4 nTPM
Bronchus	129.4 nTPM

Basal squamous epithelial cells	75.7 nTPM
Esophagus	75.7 nTPM

Undifferentiated cells	60.7 nTPM
Small intestine	74.3 nTPM
Rectum	58.4 nTPM
Colon	49.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC