Single cell type - SURF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SURF2
Gene descriptionⁱ Full gene name according to HGNC.	Surfeit 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SURF2 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PSMF1	Proteasome inhibitor subunit 1	0.7074	31
EIF5A2	Eukaryotic translation initiation factor 5A2	0.7042	34
FAM229B	Family with sequence similarity 229 member B	0.7003	31
CMTM1	CKLF like MARVEL transmembrane domain containing 1	0.6915	31
PPP1R7	Protein phosphatase 1 regulatory subunit 7	0.6826	34
YPEL1	Yippee like 1	0.6806	31
NTMT1	N-terminal Xaa-Pro-Lys N-methyltransferase 1	0.6778	31
RABIF	RAB interacting factor	0.6747	31
SH2D7	SH2 domain containing 7	0.6740	31
SPATA33	Spermatogenesis associated 33	0.6731	34
SPA17	Sperm autoantigenic protein 17	0.6730	31
ST6GALNAC2	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	0.6702	31
MLF1	Myeloid leukemia factor 1	0.6629	31
LURAP1	Leucine rich adaptor protein 1	0.6378	31
COIL	Coilin	0.6329	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.7 nTPM
Breast	39.5 nTPM
Adipose tissue	14.0 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	11.5 nTPM
Lung	11.5 nTPM

Astrocytes	3.3 nTPM
Brain	3.3 nTPM

B-cells	23.2 nTPM
Liver	32.2 nTPM
PBMC	31.5 nTPM
Breast	29.4 nTPM
Spleen	26.9 nTPM
Kidney	23.8 nTPM
Colon	22.3 nTPM
Stomach	20.0 nTPM
Lymph node	18.9 nTPM
Adipose tissue	13.5 nTPM
Bone marrow	13.1 nTPM

Dendritic cells	25.0 nTPM
Breast	35.7 nTPM
Adipose tissue	27.4 nTPM
PBMC	12.0 nTPM

Endothelial cells	20.9 nTPM
Pancreas	38.6 nTPM
Skin	34.6 nTPM
Placenta	31.3 nTPM
Testis	29.0 nTPM
Breast	26.3 nTPM
Ovary	25.8 nTPM
Liver	23.8 nTPM
Eye	18.6 nTPM
Skeletal muscle	15.2 nTPM
Esophagus	12.9 nTPM
Heart muscle	12.5 nTPM
Prostate	11.3 nTPM
Endometrium	9.7 nTPM
Lung	3.1 nTPM

Fibroblasts	19.3 nTPM
Skin	31.5 nTPM
Ovary	30.6 nTPM
Placenta	23.6 nTPM
Breast	22.3 nTPM
Stomach	20.8 nTPM
Heart muscle	19.4 nTPM
Adipose tissue	15.0 nTPM
Esophagus	13.9 nTPM
Skeletal muscle	13.2 nTPM
Prostate	12.2 nTPM
Lung	10.1 nTPM

Intestinal goblet cells	21.5 nTPM
Colon	25.0 nTPM
Small intestine	23.7 nTPM
Rectum	15.9 nTPM

Macrophages	18.7 nTPM
Kidney	38.6 nTPM
Pancreas	28.0 nTPM
Breast	26.2 nTPM
Testis	26.1 nTPM
Bone marrow	22.5 nTPM
Ovary	20.0 nTPM
Skeletal muscle	16.7 nTPM
Lung	16.6 nTPM
Adipose tissue	15.5 nTPM
Endometrium	15.3 nTPM
Stomach	14.7 nTPM
Esophagus	14.2 nTPM
Spleen	13.5 nTPM
Prostate	12.6 nTPM
PBMC	0.0 nTPM

Paneth cells	37.4 nTPM
Colon	59.3 nTPM
Small intestine	30.0 nTPM
Rectum	22.9 nTPM

Plasma cells	19.6 nTPM
Spleen	24.3 nTPM
Bone marrow	23.0 nTPM
Esophagus	18.4 nTPM
Stomach	17.3 nTPM
Adipose tissue	14.9 nTPM

Respiratory ciliated cells	60.2 nTPM
Bronchus	67.8 nTPM
Lung	52.5 nTPM

Smooth muscle cells	26.8 nTPM
Pancreas	39.4 nTPM
Skin	38.3 nTPM
Breast	37.7 nTPM
Ovary	34.3 nTPM
Bronchus	28.2 nTPM
Prostate	25.6 nTPM
Heart muscle	21.9 nTPM
Skeletal muscle	19.4 nTPM
Endometrium	17.2 nTPM
Adipose tissue	17.0 nTPM
Esophagus	15.5 nTPM

T-cells	38.2 nTPM
Skin	82.0 nTPM
Colon	65.6 nTPM
Spleen	44.6 nTPM
Breast	44.6 nTPM
Stomach	42.3 nTPM
Kidney	41.1 nTPM
Adipose tissue	39.5 nTPM
PBMC	37.5 nTPM
Bone marrow	35.9 nTPM
Ovary	35.6 nTPM
Liver	32.3 nTPM
Lymph node	28.6 nTPM
Prostate	28.4 nTPM
Endometrium	27.4 nTPM
Skeletal muscle	26.4 nTPM
Lung	24.3 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	84.1 nTPM
Skin	84.1 nTPM

Basal prostatic cells	27.6 nTPM
Prostate	27.6 nTPM

Basal respiratory cells	53.7 nTPM
Bronchus	53.7 nTPM

Basal squamous epithelial cells	50.7 nTPM
Esophagus	50.7 nTPM

Undifferentiated cells	30.1 nTPM
Colon	41.0 nTPM
Small intestine	25.8 nTPM
Rectum	23.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC