Single cell type - TNKS1BP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TNKS1BP1
Gene descriptionⁱ Full gene name according to HGNC.	Tankyrase 1 binding protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TNKS1BP1 is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PPL	Periplakin	0.6694	61
IVL	Involucrin	0.6527	61
TMEM79	Transmembrane protein 79	0.6132	61
AHNAK2	AHNAK nucleoprotein 2	0.6002	26
EPHX3	Epoxide hydrolase 3	0.5976	61
GSDMC	Gasdermin C	0.5912	61
TMTC3	Transmembrane O-mannosyltransferase targeting cadherins 3	0.5864	61
LY6D	Lymphocyte antigen 6 family member D	0.5848	61
LGALS7	Galectin 7	0.5751	61
SLURP1	Secreted LY6/PLAUR domain containing 1	0.5712	61
PKP1	Plakophilin 1	0.5705	61
SNX33	Sorting nexin 33	0.5646	50
CAPNS2	Calpain small subunit 2	0.5606	61
FOXQ1	Forkhead box Q1	0.5580	61
KRT6B	Keratin 6B	0.5566	61

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.1 nTPM
Adipose tissue	44.4 nTPM
Breast	31.7 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	35.4 nTPM
Lung	35.4 nTPM

Astrocytes	12.7 nTPM
Brain	12.7 nTPM

B-cells	1.9 nTPM
Breast	4.0 nTPM
Liver	2.9 nTPM
PBMC	2.8 nTPM
Lymph node	2.0 nTPM
Stomach	1.8 nTPM
Bone marrow	1.7 nTPM
Spleen	1.7 nTPM
Colon	1.6 nTPM
Adipose tissue	1.0 nTPM
Kidney	0.0 nTPM

Dendritic cells	1.3 nTPM
Breast	2.9 nTPM
Adipose tissue	1.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	25.9 nTPM
Skeletal muscle	47.4 nTPM
Prostate	35.7 nTPM
Skin	32.2 nTPM
Esophagus	29.4 nTPM
Ovary	28.5 nTPM
Placenta	28.4 nTPM
Testis	27.9 nTPM
Endometrium	26.5 nTPM
Heart muscle	24.2 nTPM
Liver	22.9 nTPM
Eye	21.0 nTPM
Breast	19.8 nTPM
Pancreas	15.5 nTPM
Lung	3.1 nTPM

Fibroblasts	31.2 nTPM
Skeletal muscle	57.1 nTPM
Skin	42.5 nTPM
Esophagus	36.4 nTPM
Adipose tissue	34.6 nTPM
Breast	32.8 nTPM
Ovary	26.9 nTPM
Lung	25.7 nTPM
Heart muscle	25.3 nTPM
Stomach	22.3 nTPM
Placenta	19.9 nTPM
Prostate	19.6 nTPM

Intestinal goblet cells	25.8 nTPM
Colon	33.6 nTPM
Rectum	27.0 nTPM
Small intestine	16.8 nTPM

Macrophages	3.8 nTPM
Skeletal muscle	8.3 nTPM
Esophagus	7.9 nTPM
Stomach	5.9 nTPM
Endometrium	5.4 nTPM
Pancreas	5.1 nTPM
Lung	4.4 nTPM
Adipose tissue	4.2 nTPM
Prostate	3.4 nTPM
Kidney	3.0 nTPM
Testis	2.9 nTPM
Breast	2.5 nTPM
Ovary	2.4 nTPM
Bone marrow	1.2 nTPM
Spleen	1.0 nTPM
PBMC	0.0 nTPM

Paneth cells	14.3 nTPM
Colon	19.7 nTPM
Rectum	15.7 nTPM
Small intestine	7.5 nTPM

Plasma cells	0.6 nTPM
Stomach	1.7 nTPM
Adipose tissue	0.6 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	15.4 nTPM
Bronchus	29.4 nTPM
Lung	1.5 nTPM

Smooth muscle cells	26.9 nTPM
Skeletal muscle	44.5 nTPM
Bronchus	43.7 nTPM
Adipose tissue	33.2 nTPM
Esophagus	24.8 nTPM
Skin	24.1 nTPM
Heart muscle	22.0 nTPM
Breast	22.0 nTPM
Ovary	21.2 nTPM
Pancreas	21.0 nTPM
Endometrium	20.4 nTPM
Prostate	18.7 nTPM

T-cells	2.3 nTPM
Skin	6.0 nTPM
Endometrium	5.2 nTPM
Lung	4.5 nTPM
Ovary	4.5 nTPM
Breast	3.1 nTPM
Lymph node	2.8 nTPM
Liver	2.1 nTPM
Stomach	2.0 nTPM
Colon	1.9 nTPM
Spleen	1.5 nTPM
Adipose tissue	1.4 nTPM
Bone marrow	1.1 nTPM
Skeletal muscle	0.8 nTPM
Kidney	0.7 nTPM
PBMC	0.6 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	83.6 nTPM
Skin	83.6 nTPM

Basal prostatic cells	28.0 nTPM
Prostate	28.0 nTPM

Basal respiratory cells	61.9 nTPM
Bronchus	61.9 nTPM

Cholangiocytes	38.6 nTPM
Liver	38.6 nTPM

Undifferentiated cells	14.5 nTPM
Rectum	18.7 nTPM
Colon	16.3 nTPM
Small intestine	8.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC