Single cell type - ARFGAP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARFGAP2
Gene descriptionⁱ Full gene name according to HGNC.	ADP ribosylation factor GTPase activating protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ARFGAP2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RBM23	RNA binding motif protein 23	0.6300	52
TTF1	Transcription termination factor 1	0.5186	6
ZNF439	Zinc finger protein 439	0.5067	52
C19orf25	Chromosome 19 open reading frame 25	0.5035	52
NRDE2	NRDE-2, necessary for RNA interference, domain containing	0.5035	52
PNKP	Polynucleotide kinase 3'-phosphatase	0.5015	52
DPP9	Dipeptidyl peptidase 9	0.4913	52
ZNF7	Zinc finger protein 7	0.4905	52
SIRT7	Sirtuin 7	0.4862	53
TTC31	Tetratricopeptide repeat domain 31	0.4861	52
SPRTN	SprT-like N-terminal domain	0.4784	9
DHX16	DEAH-box helicase 16	0.4712	66
POU5F2	POU domain class 5, transcription factor 2	0.4673	66
GGA1	Golgi associated, gamma adaptin ear containing, ARF binding protein 1	0.4624	66
PILRB	Paired immunoglobin like type 2 receptor beta	0.4585	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.8 nTPM
Breast	27.7 nTPM
Adipose tissue	19.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	45.9 nTPM
Lung	45.9 nTPM

Astrocytes	25.1 nTPM
Brain	25.1 nTPM

B-cells	46.5 nTPM
Colon	87.9 nTPM
PBMC	61.4 nTPM
Stomach	47.7 nTPM
Kidney	42.9 nTPM
Spleen	40.5 nTPM
Bone marrow	40.0 nTPM
Breast	38.8 nTPM
Adipose tissue	37.1 nTPM
Liver	34.9 nTPM
Lymph node	33.7 nTPM

Dendritic cells	40.7 nTPM
Breast	55.0 nTPM
Adipose tissue	51.0 nTPM
PBMC	16.0 nTPM

Endothelial cells	29.8 nTPM
Pancreas	50.2 nTPM
Lung	49.9 nTPM
Eye	37.2 nTPM
Ovary	35.9 nTPM
Placenta	34.1 nTPM
Testis	30.2 nTPM
Liver	29.3 nTPM
Skeletal muscle	26.1 nTPM
Endometrium	23.6 nTPM
Breast	21.9 nTPM
Prostate	21.8 nTPM
Esophagus	21.7 nTPM
Skin	18.8 nTPM
Heart muscle	17.2 nTPM

Fibroblasts	29.7 nTPM
Ovary	37.1 nTPM
Lung	36.9 nTPM
Placenta	35.9 nTPM
Adipose tissue	35.0 nTPM
Breast	33.9 nTPM
Skeletal muscle	27.5 nTPM
Prostate	27.0 nTPM
Esophagus	26.5 nTPM
Skin	25.9 nTPM
Stomach	22.3 nTPM
Heart muscle	18.7 nTPM

Intestinal goblet cells	35.0 nTPM
Colon	45.0 nTPM
Rectum	30.9 nTPM
Small intestine	29.3 nTPM

Macrophages	28.6 nTPM
Ovary	52.6 nTPM
Kidney	35.6 nTPM
Breast	35.6 nTPM
Bone marrow	35.0 nTPM
Pancreas	33.2 nTPM
Testis	33.1 nTPM
Adipose tissue	33.0 nTPM
Lung	31.1 nTPM
Endometrium	30.4 nTPM
Skeletal muscle	25.0 nTPM
Prostate	21.8 nTPM
Stomach	17.6 nTPM
Spleen	16.5 nTPM
Esophagus	14.2 nTPM
PBMC	13.6 nTPM

Paneth cells	45.0 nTPM
Colon	52.6 nTPM
Rectum	44.6 nTPM
Small intestine	37.6 nTPM

Plasma cells	31.7 nTPM
Adipose tissue	43.2 nTPM
Bone marrow	31.3 nTPM
Stomach	30.1 nTPM
Spleen	29.3 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	34.1 nTPM
Lung	46.6 nTPM
Bronchus	21.5 nTPM

Smooth muscle cells	28.0 nTPM
Ovary	35.5 nTPM
Breast	34.1 nTPM
Bronchus	33.0 nTPM
Pancreas	32.6 nTPM
Prostate	31.0 nTPM
Skeletal muscle	31.0 nTPM
Skin	30.3 nTPM
Adipose tissue	24.9 nTPM
Endometrium	21.6 nTPM
Heart muscle	19.5 nTPM
Esophagus	14.0 nTPM

T-cells	43.7 nTPM
Colon	81.2 nTPM
Liver	63.8 nTPM
Kidney	62.9 nTPM
PBMC	57.9 nTPM
Ovary	55.6 nTPM
Breast	47.8 nTPM
Lung	47.1 nTPM
Adipose tissue	41.7 nTPM
Skeletal muscle	40.8 nTPM
Stomach	39.1 nTPM
Bone marrow	37.6 nTPM
Skin	36.4 nTPM
Endometrium	34.0 nTPM
Spleen	31.3 nTPM
Prostate	23.6 nTPM
Lymph node	23.0 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	22.2 nTPM
Skin	22.2 nTPM

Basal prostatic cells	31.4 nTPM
Prostate	31.4 nTPM

Basal respiratory cells	22.1 nTPM
Bronchus	22.1 nTPM

Basal squamous epithelial cells	29.6 nTPM
Esophagus	29.6 nTPM

Undifferentiated cells	36.3 nTPM
Colon	49.1 nTPM
Small intestine	31.4 nTPM
Rectum	28.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC