Single cell type - RILPL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RILPL2
Gene descriptionⁱ Full gene name according to HGNC.	Rab interacting lysosomal protein like 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Macrophages, B-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, NB-4, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Macrophages, B-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RILPL2 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NLRP3	NLR family pyrin domain containing 3	0.8822	41
BCL2A1	BCL2 related protein A1	0.8667	41
IL1B	Interleukin 1 beta	0.8639	41
EREG	Epiregulin	0.8632	41
GPR132	G protein-coupled receptor 132	0.8600	41
LORICRIN	Loricrin cornified envelope precursor protein	0.8331	41
ACOD1	Aconitate decarboxylase 1	0.8257	41
RASGEF1B	RasGEF domain family member 1B	0.8210	41
MARCHF1	Membrane associated ring-CH-type finger 1	0.8194	41
C5AR1	Complement C5a receptor 1	0.8050	41
SERPINB9	Serpin family B member 9	0.7973	41
NAMPT	Nicotinamide phosphoribosyltransferase	0.7898	41
CHMP1B	Charged multivesicular body protein 1B	0.7884	41
CYRIA	CYFIP related Rac1 interactor A	0.7870	41
TASL	TLR adaptor interacting with endolysosomal SLC15A4	0.7868	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	75.7 nTPM
Breast	80.3 nTPM
Adipose tissue	71.2 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	75.2 nTPM
Lung	75.2 nTPM

Astrocytes	7.2 nTPM
Brain	7.2 nTPM

Basal keratinocytes	24.5 nTPM
Skin	24.5 nTPM

B-cells	149.8 nTPM
Adipose tissue	464.1 nTPM
Colon	209.2 nTPM
Stomach	188.5 nTPM
Spleen	167.1 nTPM
Lymph node	157.9 nTPM
Breast	116.3 nTPM
Kidney	71.4 nTPM
Bone marrow	52.3 nTPM
PBMC	44.2 nTPM
Liver	26.6 nTPM

Dendritic cells	75.0 nTPM
Breast	81.3 nTPM
Adipose tissue	75.9 nTPM
PBMC	67.8 nTPM

Endothelial cells	73.2 nTPM
Prostate	127.7 nTPM
Skin	119.8 nTPM
Liver	118.3 nTPM
Eye	106.0 nTPM
Testis	90.7 nTPM
Breast	81.0 nTPM
Esophagus	76.1 nTPM
Skeletal muscle	67.3 nTPM
Pancreas	54.0 nTPM
Lung	53.0 nTPM
Endometrium	39.1 nTPM
Ovary	36.7 nTPM
Placenta	35.8 nTPM
Heart muscle	18.6 nTPM

Fibroblasts	28.2 nTPM
Prostate	78.3 nTPM
Skin	39.5 nTPM
Stomach	35.6 nTPM
Lung	31.3 nTPM
Esophagus	22.5 nTPM
Heart muscle	21.1 nTPM
Breast	20.3 nTPM
Placenta	18.0 nTPM
Skeletal muscle	16.2 nTPM
Adipose tissue	14.5 nTPM
Ovary	13.1 nTPM

Intestinal goblet cells	8.1 nTPM
Small intestine	10.3 nTPM
Colon	9.3 nTPM
Rectum	4.7 nTPM

Macrophages	288.7 nTPM
Adipose tissue	942.3 nTPM
Stomach	650.5 nTPM
Prostate	454.0 nTPM
Skeletal muscle	447.0 nTPM
Spleen	273.7 nTPM
Breast	257.6 nTPM
PBMC	204.6 nTPM
Esophagus	187.3 nTPM
Lung	173.7 nTPM
Endometrium	152.7 nTPM
Pancreas	148.0 nTPM
Ovary	139.0 nTPM
Kidney	127.8 nTPM
Bone marrow	94.9 nTPM
Testis	77.8 nTPM

Paneth cells	6.4 nTPM
Small intestine	15.0 nTPM
Rectum	4.2 nTPM
Colon	0.0 nTPM

Plasma cells	25.7 nTPM
Adipose tissue	58.6 nTPM
Bone marrow	31.3 nTPM
Spleen	25.9 nTPM
Stomach	6.3 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	47.1 nTPM
Lung	55.4 nTPM
Bronchus	38.8 nTPM

Smooth muscle cells	30.1 nTPM
Prostate	79.1 nTPM
Heart muscle	43.5 nTPM
Breast	40.6 nTPM
Endometrium	29.3 nTPM
Skin	28.6 nTPM
Esophagus	21.7 nTPM
Pancreas	21.2 nTPM
Skeletal muscle	17.3 nTPM
Adipose tissue	17.2 nTPM
Ovary	16.7 nTPM
Bronchus	16.1 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	10.1 nTPM
Placenta	10.1 nTPM

Distal tubular cells	25.4 nTPM
Kidney	25.4 nTPM

T-cells	92.5 nTPM
Adipose tissue	251.9 nTPM
Skin	164.9 nTPM
Breast	144.5 nTPM
Prostate	108.9 nTPM
Lymph node	90.5 nTPM
Spleen	85.8 nTPM
Skeletal muscle	84.9 nTPM
Colon	83.6 nTPM
Kidney	78.0 nTPM
Lung	74.4 nTPM
Ovary	73.4 nTPM
Esophagus	65.5 nTPM
Endometrium	62.1 nTPM
Stomach	57.9 nTPM
Liver	52.5 nTPM
PBMC	47.0 nTPM
Bone marrow	45.9 nTPM

Undifferentiated cells	4.8 nTPM
Small intestine	7.9 nTPM
Colon	3.7 nTPM
Rectum	2.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC