Single cell type - WWC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WWC2
Gene descriptionⁱ Full gene name according to HGNC.	WW and C2 domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Alveolar cells - Smell perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SiHa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

WWC2 is part of cluster 11 Alveolar cells - Smell perception with confidenceⁱ 1
281 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ESYT3	Extended synaptotagmin 3	0.6838	11
ABCA3	ATP binding cassette subfamily A member 3	0.5907	11
MS4A15	Membrane spanning 4-domains A15	0.5892	11
VEPH1	Ventricular zone expressed PH domain containing 1	0.5842	11
SFTA2	Surfactant associated 2	0.5839	11
AL132780.3	Novel protein	0.5766	11
AGER	Advanced glycosylation end-product specific receptor	0.5652	11
AC099811.2	Novel protein	0.5519	11
NKX2-1	NK2 homeobox 1	0.5411	11
EPB41L5	Erythrocyte membrane protein band 4.1 like 5	0.5288	11
NAPSA	Napsin A aspartic peptidase	0.5262	11
CST5	Cystatin D	0.5259	11
AGTR2	Angiotensin II receptor type 2	0.5245	11
CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2	0.5244	11
AC011479.1	Novel protein	0.5218	11

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.8 nTPM
Adipose tissue	30.9 nTPM
Breast	24.8 nTPM

Alveolar cells type 2	65.4 nTPM
Lung	65.4 nTPM

Astrocytes	23.2 nTPM
Brain	23.2 nTPM

B-cells	0.4 nTPM
Liver	2.1 nTPM
Breast	1.3 nTPM
Adipose tissue	0.5 nTPM
Lymph node	0.4 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	24.0 nTPM
Skin	24.0 nTPM

Dendritic cells	1.4 nTPM
Adipose tissue	2.7 nTPM
Breast	1.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	27.4 nTPM
Eye	50.2 nTPM
Prostate	42.3 nTPM
Skeletal muscle	40.3 nTPM
Ovary	33.9 nTPM
Endometrium	30.8 nTPM
Heart muscle	28.8 nTPM
Esophagus	26.4 nTPM
Lung	21.8 nTPM
Placenta	21.6 nTPM
Testis	20.7 nTPM
Skin	19.8 nTPM
Breast	18.3 nTPM
Liver	16.5 nTPM
Pancreas	11.6 nTPM

Fibroblasts	25.0 nTPM
Lung	38.0 nTPM
Prostate	33.5 nTPM
Skeletal muscle	31.1 nTPM
Ovary	30.1 nTPM
Heart muscle	30.0 nTPM
Stomach	22.3 nTPM
Adipose tissue	20.9 nTPM
Skin	20.3 nTPM
Placenta	19.1 nTPM
Esophagus	17.7 nTPM
Breast	12.0 nTPM

Intestinal goblet cells	0.2 nTPM
Rectum	0.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	9.0 nTPM
Skeletal muscle	18.9 nTPM
Spleen	15.6 nTPM
Ovary	14.4 nTPM
Adipose tissue	12.3 nTPM
Testis	11.7 nTPM
Esophagus	11.0 nTPM
Kidney	10.6 nTPM
Lung	10.1 nTPM
Breast	7.5 nTPM
Endometrium	6.8 nTPM
Stomach	5.9 nTPM
Bone marrow	5.0 nTPM
Prostate	3.4 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	0.8 nTPM
Adipose tissue	2.7 nTPM
Stomach	1.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	11.5 nTPM
Lung	16.0 nTPM
Bronchus	6.9 nTPM

Smooth muscle cells	24.2 nTPM
Ovary	70.7 nTPM
Endometrium	31.1 nTPM
Prostate	29.1 nTPM
Skeletal muscle	23.7 nTPM
Adipose tissue	21.3 nTPM
Pancreas	20.9 nTPM
Skin	17.8 nTPM
Breast	17.5 nTPM
Heart muscle	14.6 nTPM
Bronchus	10.4 nTPM
Esophagus	9.3 nTPM

T-cells	3.2 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Prostate	4.7 nTPM
Endometrium	4.7 nTPM
Lung	4.5 nTPM
Skeletal muscle	4.4 nTPM
Kidney	4.2 nTPM
Liver	2.7 nTPM
PBMC	2.3 nTPM
Adipose tissue	2.1 nTPM
Lymph node	2.0 nTPM
Skin	1.9 nTPM
Bone marrow	1.9 nTPM
Breast	1.8 nTPM
Spleen	1.6 nTPM
Stomach	1.2 nTPM
Colon	1.0 nTPM

Cholangiocytes	37.1 nTPM
Liver	37.1 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cone photoreceptor cells	64.6 nTPM
Eye	64.6 nTPM

Cytotrophoblasts	15.4 nTPM
Placenta	15.4 nTPM

Undifferentiated cells	0.4 nTPM
Colon	0.9 nTPM
Rectum	0.4 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC