Single cell type - AHCTF1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AHCTF1
Gene descriptionⁱ Full gene name according to HGNC.	AT-hook containing transcription factor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AHCTF1 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ACRBP	Acrosin binding protein	0.6845	51
TRAPPC3L	Trafficking protein particle complex 3 like	0.6444	51
ACER1	Alkaline ceramidase 1	0.6417	51
NRGN	Neurogranin	0.6383	51
RUFY1	RUN and FYVE domain containing 1	0.6182	51
ZSCAN22	Zinc finger and SCAN domain containing 22	0.6141	51
TBXA2R	Thromboxane A2 receptor	0.6093	51
CDKN2D	Cyclin dependent kinase inhibitor 2D	0.6086	51
MMD	Monocyte to macrophage differentiation associated	0.6059	51
CGRRF1	Cell growth regulator with ring finger domain 1	0.6052	66
GP6	Glycoprotein VI platelet	0.5961	51
ITGB3	Integrin subunit beta 3	0.5948	51
RGS18	Regulator of G protein signaling 18	0.5926	51
SCGB1C1	Secretoglobin family 1C member 1	0.5885	51
CMTM5	CKLF like MARVEL transmembrane domain containing 5	0.5865	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	53.7 nTPM
Adipose tissue	65.1 nTPM
Breast	42.2 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	35.0 nTPM
Lung	35.0 nTPM

Astrocytes	37.2 nTPM
Brain	37.2 nTPM

B-cells	32.9 nTPM
Lymph node	57.6 nTPM
Spleen	53.6 nTPM
Adipose tissue	48.2 nTPM
Bone marrow	44.9 nTPM
Breast	33.4 nTPM
Stomach	32.7 nTPM
Liver	21.6 nTPM
Colon	14.4 nTPM
PBMC	12.9 nTPM
Kidney	9.5 nTPM

Dendritic cells	27.4 nTPM
Adipose tissue	41.7 nTPM
Breast	32.4 nTPM
PBMC	8.0 nTPM

Endothelial cells	25.9 nTPM
Skeletal muscle	44.9 nTPM
Testis	39.4 nTPM
Endometrium	36.0 nTPM
Prostate	35.9 nTPM
Esophagus	33.4 nTPM
Lung	31.2 nTPM
Ovary	30.3 nTPM
Heart muscle	25.0 nTPM
Breast	22.3 nTPM
Skin	16.9 nTPM
Eye	16.2 nTPM
Pancreas	11.6 nTPM
Placenta	11.3 nTPM
Liver	8.2 nTPM

Fibroblasts	30.5 nTPM
Adipose tissue	52.3 nTPM
Skeletal muscle	42.9 nTPM
Lung	41.3 nTPM
Heart muscle	41.0 nTPM
Prostate	29.4 nTPM
Esophagus	28.9 nTPM
Ovary	26.5 nTPM
Breast	20.9 nTPM
Stomach	20.8 nTPM
Skin	16.9 nTPM
Placenta	14.6 nTPM

Intestinal goblet cells	12.9 nTPM
Rectum	14.0 nTPM
Small intestine	13.2 nTPM
Colon	11.4 nTPM

Macrophages	57.4 nTPM
PBMC	450.1 nTPM
Stomach	55.7 nTPM
Skeletal muscle	47.0 nTPM
Adipose tissue	46.1 nTPM
Spleen	37.4 nTPM
Lung	32.0 nTPM
Endometrium	28.7 nTPM
Breast	28.3 nTPM
Ovary	23.7 nTPM
Bone marrow	23.7 nTPM
Testis	20.9 nTPM
Pancreas	20.4 nTPM
Esophagus	18.9 nTPM
Prostate	15.0 nTPM
Kidney	12.9 nTPM

Paneth cells	13.0 nTPM
Colon	16.5 nTPM
Small intestine	11.3 nTPM
Rectum	11.3 nTPM

Plasma cells	35.8 nTPM
Adipose tissue	57.4 nTPM
Esophagus	36.9 nTPM
Spleen	32.5 nTPM
Bone marrow	31.3 nTPM
Stomach	20.8 nTPM

Respiratory ciliated cells	20.4 nTPM
Lung	23.3 nTPM
Bronchus	17.5 nTPM

Smooth muscle cells	26.1 nTPM
Esophagus	37.2 nTPM
Endometrium	33.6 nTPM
Skeletal muscle	32.2 nTPM
Adipose tissue	31.7 nTPM
Heart muscle	28.2 nTPM
Breast	26.7 nTPM
Skin	25.8 nTPM
Ovary	25.1 nTPM
Prostate	21.9 nTPM
Pancreas	16.3 nTPM
Bronchus	8.6 nTPM

T-cells	31.3 nTPM
Lymph node	52.9 nTPM
Esophagus	52.4 nTPM
Adipose tissue	50.4 nTPM
Spleen	40.2 nTPM
Endometrium	39.6 nTPM
Skeletal muscle	39.3 nTPM
Breast	36.1 nTPM
Prostate	33.1 nTPM
Bone marrow	31.7 nTPM
Lung	30.4 nTPM
Stomach	28.6 nTPM
PBMC	25.2 nTPM
Colon	20.5 nTPM
Skin	14.3 nTPM
Ovary	13.4 nTPM
Liver	13.1 nTPM
Kidney	11.6 nTPM

Basal keratinocytes	30.0 nTPM
Skin	30.0 nTPM

Basal prostatic cells	22.4 nTPM
Prostate	22.4 nTPM

Basal respiratory cells	10.3 nTPM
Bronchus	10.3 nTPM

Basal squamous epithelial cells	40.5 nTPM
Esophagus	40.5 nTPM

Undifferentiated cells	12.4 nTPM
Rectum	13.9 nTPM
Colon	12.7 nTPM
Small intestine	10.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC