Single cell type - TRIP12 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIP12
Gene descriptionⁱ Full gene name according to HGNC.	Thyroid hormone receptor interactor 12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRIP12 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAOK1	TAO kinase 1	0.6283	10
ZDHHC20	Zinc finger DHHC-type palmitoyltransferase 20	0.6048	42
SMG7	SMG7 nonsense mediated mRNA decay factor	0.5791	44
STRN	Striatin	0.5228	42
ADAM10	ADAM metallopeptidase domain 10	0.5070	42
SETX	Senataxin	0.5026	44
ITCH	Itchy E3 ubiquitin protein ligase	0.4882	25
WDFY1	WD repeat and FYVE domain containing 1	0.4778	44
NIPBL	NIPBL cohesin loading factor	0.4722	10
PSME4	Proteasome activator subunit 4	0.4681	44
SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2	0.4607	44
YTHDF3	YTH N6-methyladenosine RNA binding protein 3	0.4604	44
GAPVD1	GTPase activating protein and VPS9 domains 1	0.4593	10
EP300	E1A binding protein p300	0.4533	44
PTBP3	Polypyrimidine tract binding protein 3	0.4508	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	78.3 nTPM
Adipose tissue	95.6 nTPM
Breast	60.9 nTPM

Alveolar cells type 1	89.8 nTPM
Lung	89.8 nTPM

Alveolar cells type 2	51.2 nTPM
Lung	51.2 nTPM

Astrocytes	85.8 nTPM
Brain	85.8 nTPM

B-cells	43.4 nTPM
Adipose tissue	66.2 nTPM
Lymph node	52.8 nTPM
Bone marrow	50.7 nTPM
Colon	49.5 nTPM
Spleen	48.2 nTPM
PBMC	45.7 nTPM
Stomach	44.0 nTPM
Breast	40.2 nTPM
Liver	32.1 nTPM
Kidney	4.8 nTPM

Dendritic cells	60.8 nTPM
PBMC	71.8 nTPM
Adipose tissue	68.1 nTPM
Breast	42.7 nTPM

Endothelial cells	59.3 nTPM
Heart muscle	106.1 nTPM
Lung	93.6 nTPM
Skeletal muscle	71.1 nTPM
Ovary	71.0 nTPM
Endometrium	67.0 nTPM
Esophagus	63.0 nTPM
Prostate	60.2 nTPM
Testis	54.3 nTPM
Liver	50.4 nTPM
Breast	47.7 nTPM
Eye	46.1 nTPM
Skin	44.9 nTPM
Placenta	31.3 nTPM
Pancreas	23.1 nTPM

Fibroblasts	43.7 nTPM
Heart muscle	63.2 nTPM
Lung	60.3 nTPM
Stomach	49.0 nTPM
Skeletal muscle	47.7 nTPM
Ovary	44.6 nTPM
Adipose tissue	42.8 nTPM
Esophagus	41.8 nTPM
Prostate	35.2 nTPM
Breast	34.8 nTPM
Skin	30.8 nTPM
Placenta	30.0 nTPM

Intestinal goblet cells	32.5 nTPM
Small intestine	33.9 nTPM
Rectum	33.5 nTPM
Colon	30.0 nTPM

Macrophages	70.8 nTPM
Spleen	151.4 nTPM
Stomach	117.2 nTPM
Bone marrow	110.0 nTPM
Lung	94.3 nTPM
Adipose tissue	93.1 nTPM
Esophagus	86.6 nTPM
Skeletal muscle	83.9 nTPM
Ovary	69.8 nTPM
Endometrium	55.7 nTPM
Kidney	48.5 nTPM
Testis	45.9 nTPM
Breast	40.2 nTPM
Prostate	32.0 nTPM
Pancreas	20.4 nTPM
PBMC	13.6 nTPM

Paneth cells	35.0 nTPM
Colon	42.8 nTPM
Rectum	35.7 nTPM
Small intestine	26.3 nTPM

Plasma cells	52.1 nTPM
Adipose tissue	90.4 nTPM
Esophagus	67.8 nTPM
Spleen	41.6 nTPM
Stomach	31.0 nTPM
Bone marrow	29.7 nTPM

Respiratory ciliated cells	73.1 nTPM
Bronchus	74.8 nTPM
Lung	71.4 nTPM

Smooth muscle cells	45.0 nTPM
Heart muscle	65.3 nTPM
Adipose tissue	55.2 nTPM
Ovary	54.2 nTPM
Endometrium	53.6 nTPM
Skeletal muscle	51.0 nTPM
Prostate	43.5 nTPM
Esophagus	41.9 nTPM
Breast	36.1 nTPM
Bronchus	35.0 nTPM
Skin	30.0 nTPM
Pancreas	29.7 nTPM

T-cells	47.0 nTPM
Lung	69.8 nTPM
Endometrium	68.2 nTPM
Adipose tissue	67.0 nTPM
Lymph node	61.6 nTPM
Skeletal muscle	60.2 nTPM
Spleen	54.0 nTPM
Bone marrow	53.2 nTPM
Stomach	52.0 nTPM
Esophagus	45.9 nTPM
Colon	43.2 nTPM
Breast	41.4 nTPM
PBMC	39.9 nTPM
Liver	38.9 nTPM
Ovary	28.9 nTPM
Prostate	28.4 nTPM
Kidney	25.3 nTPM
Skin	21.2 nTPM

Basal prostatic cells	32.8 nTPM
Prostate	32.8 nTPM

Basal respiratory cells	36.3 nTPM
Bronchus	36.3 nTPM

Basal squamous epithelial cells	25.6 nTPM
Esophagus	25.6 nTPM

Cholangiocytes	34.3 nTPM
Liver	34.3 nTPM

Undifferentiated cells	31.9 nTPM
Colon	36.1 nTPM
Rectum	34.0 nTPM
Small intestine	25.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC