Single cell type - MPPE1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPPE1
Gene descriptionⁱ Full gene name according to HGNC.	Metallophosphoesterase 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPPE1 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SUN2	Sad1 and UNC84 domain containing 2	0.5060	63
SLAMF6	SLAM family member 6	0.4818	63
CAP1	Cyclase associated actin cytoskeleton regulatory protein 1	0.4817	16
RINL	Ras and Rab interactor like	0.4737	63
HCST	Hematopoietic cell signal transducer	0.4727	63
PPIL2	Peptidylprolyl isomerase like 2	0.4721	34
PTGER2	Prostaglandin E receptor 2	0.4681	63
GBP3	Guanylate binding protein 3	0.4520	53
MED15	Mediator complex subunit 15	0.4492	63
PPP1CA	Protein phosphatase 1 catalytic subunit alpha	0.4491	53
ADCY7	Adenylate cyclase 7	0.4425	63
IL12RB1	Interleukin 12 receptor subunit beta 1	0.4415	63
SEC24C	SEC24 homolog C, COPII coat complex component	0.4388	63
IRAK4	Interleukin 1 receptor associated kinase 4	0.4362	63
DNAJB14	DnaJ heat shock protein family (Hsp40) member B14	0.4357	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.3 nTPM
Adipose tissue	20.4 nTPM
Breast	18.3 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	33.0 nTPM
Lung	33.0 nTPM

Astrocytes	13.4 nTPM
Brain	13.4 nTPM

B-cells	24.5 nTPM
Breast	34.7 nTPM
Adipose tissue	32.1 nTPM
Bone marrow	31.9 nTPM
Lymph node	29.0 nTPM
Stomach	27.7 nTPM
Spleen	21.8 nTPM
Liver	19.1 nTPM
Kidney	19.0 nTPM
PBMC	18.6 nTPM
Colon	11.2 nTPM

Dendritic cells	35.7 nTPM
Adipose tissue	52.1 nTPM
PBMC	31.8 nTPM
Breast	23.3 nTPM

Endothelial cells	15.5 nTPM
Lung	21.8 nTPM
Ovary	21.2 nTPM
Esophagus	20.6 nTPM
Placenta	18.8 nTPM
Testis	18.7 nTPM
Breast	17.2 nTPM
Skin	16.6 nTPM
Liver	16.5 nTPM
Skeletal muscle	16.4 nTPM
Endometrium	14.8 nTPM
Eye	12.9 nTPM
Pancreas	11.6 nTPM
Prostate	7.4 nTPM
Heart muscle	2.2 nTPM

Fibroblasts	16.6 nTPM
Skeletal muscle	26.9 nTPM
Adipose tissue	26.8 nTPM
Placenta	20.3 nTPM
Esophagus	19.1 nTPM
Skin	18.8 nTPM
Breast	18.7 nTPM
Lung	16.8 nTPM
Ovary	13.8 nTPM
Stomach	11.9 nTPM
Prostate	7.2 nTPM
Heart muscle	2.6 nTPM

Intestinal goblet cells	23.4 nTPM
Small intestine	40.9 nTPM
Rectum	17.8 nTPM
Colon	11.4 nTPM

Macrophages	24.8 nTPM
Breast	37.0 nTPM
Adipose tissue	32.6 nTPM
Lung	31.6 nTPM
Kidney	31.0 nTPM
Ovary	30.6 nTPM
Esophagus	29.9 nTPM
Testis	29.1 nTPM
Spleen	29.0 nTPM
Bone marrow	27.5 nTPM
Skeletal muscle	25.3 nTPM
Endometrium	23.2 nTPM
Stomach	20.5 nTPM
Prostate	15.0 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	18.4 nTPM
Colon	26.4 nTPM
Rectum	17.7 nTPM
Small intestine	11.3 nTPM

Plasma cells	16.0 nTPM
Adipose tissue	24.5 nTPM
Stomach	20.9 nTPM
Spleen	20.2 nTPM
Bone marrow	8.2 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	26.7 nTPM
Lung	30.6 nTPM
Bronchus	22.7 nTPM

Smooth muscle cells	13.9 nTPM
Pancreas	23.6 nTPM
Skeletal muscle	20.3 nTPM
Esophagus	20.1 nTPM
Skin	15.0 nTPM
Endometrium	14.6 nTPM
Breast	14.4 nTPM
Adipose tissue	14.1 nTPM
Prostate	10.6 nTPM
Ovary	10.5 nTPM
Bronchus	7.5 nTPM
Heart muscle	1.9 nTPM

T-cells	33.7 nTPM
Lung	62.3 nTPM
Kidney	48.0 nTPM
Liver	42.3 nTPM
Stomach	40.8 nTPM
Adipose tissue	36.3 nTPM
Spleen	36.1 nTPM
Bone marrow	35.5 nTPM
Ovary	33.3 nTPM
Colon	30.4 nTPM
PBMC	29.9 nTPM
Lymph node	28.4 nTPM
Breast	28.4 nTPM
Skin	28.1 nTPM
Skeletal muscle	27.1 nTPM
Esophagus	26.2 nTPM
Endometrium	20.4 nTPM
Prostate	19.0 nTPM

Basal keratinocytes	18.0 nTPM
Skin	18.0 nTPM

Basal prostatic cells	16.2 nTPM
Prostate	16.2 nTPM

Basal respiratory cells	20.7 nTPM
Bronchus	20.7 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Undifferentiated cells	16.1 nTPM
Small intestine	18.1 nTPM
Rectum	16.4 nTPM
Colon	13.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC