Single cell type - NDUFAF6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFAF6
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase complex assembly factor 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFAF6 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM53A	Family with sequence similarity 53 member A	0.4789	20
APOO	Apolipoprotein O	0.4747	39
NAA35	N-alpha-acetyltransferase 35, NatC auxiliary subunit	0.4740	10
ATXN7L2	Ataxin 7 like 2	0.4481	10
PRKG2	Protein kinase cGMP-dependent 2	0.4222	10
ZYG11A	Zyg-11 family member A, cell cycle regulator	0.4220	20
DCUN1D5	Defective in cullin neddylation 1 domain containing 5	0.4182	10
PLD6	Phospholipase D family member 6	0.4177	20
NDC1	NDC1 transmembrane nucleoporin	0.4070	12
POLE2	DNA polymerase epsilon 2, accessory subunit	0.4041	10
HOXC13	Homeobox C13	0.3996	28
ZCCHC4	Zinc finger CCHC-type containing 4	0.3996	59
PAFAH1B3	Platelet activating factor acetylhydrolase 1b catalytic subunit 3	0.3990	10
FBXO4	F-box protein 4	0.3988	10
FOXG1	Forkhead box G1	0.3977	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.4 nTPM
Breast	32.0 nTPM
Adipose tissue	14.8 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	15.9 nTPM
Lung	15.9 nTPM

Astrocytes	35.3 nTPM
Brain	35.3 nTPM

B-cells	23.6 nTPM
Liver	33.3 nTPM
Lymph node	30.8 nTPM
Adipose tissue	30.0 nTPM
Stomach	29.5 nTPM
Spleen	27.3 nTPM
Bone marrow	27.0 nTPM
PBMC	25.7 nTPM
Breast	16.0 nTPM
Kidney	9.5 nTPM
Colon	6.4 nTPM

Dendritic cells	14.3 nTPM
Breast	21.1 nTPM
Adipose tissue	13.6 nTPM
PBMC	8.0 nTPM

Endothelial cells	14.8 nTPM
Pancreas	30.9 nTPM
Placenta	29.6 nTPM
Breast	21.5 nTPM
Ovary	17.5 nTPM
Testis	15.4 nTPM
Skeletal muscle	13.1 nTPM
Lung	12.5 nTPM
Heart muscle	12.4 nTPM
Endometrium	12.4 nTPM
Skin	10.6 nTPM
Esophagus	8.8 nTPM
Prostate	7.5 nTPM
Eye	7.3 nTPM
Liver	7.3 nTPM

Fibroblasts	9.4 nTPM
Ovary	20.1 nTPM
Heart muscle	18.7 nTPM
Breast	12.8 nTPM
Placenta	12.2 nTPM
Skeletal muscle	8.2 nTPM
Lung	6.7 nTPM
Esophagus	6.5 nTPM
Adipose tissue	6.1 nTPM
Skin	4.9 nTPM
Prostate	4.6 nTPM
Stomach	3.0 nTPM

Intestinal goblet cells	15.3 nTPM
Rectum	16.3 nTPM
Small intestine	15.3 nTPM
Colon	14.3 nTPM

Macrophages	10.1 nTPM
Pancreas	35.7 nTPM
Esophagus	15.8 nTPM
Breast	15.3 nTPM
Ovary	11.9 nTPM
Kidney	11.4 nTPM
Prostate	10.3 nTPM
Spleen	8.3 nTPM
Bone marrow	7.5 nTPM
Skeletal muscle	7.1 nTPM
Testis	6.9 nTPM
Lung	6.4 nTPM
Endometrium	6.2 nTPM
Adipose tissue	6.2 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	18.2 nTPM
Rectum	19.3 nTPM
Small intestine	18.8 nTPM
Colon	16.5 nTPM

Plasma cells	53.1 nTPM
Esophagus	104.7 nTPM
Spleen	58.9 nTPM
Stomach	57.7 nTPM
Bone marrow	34.6 nTPM
Adipose tissue	9.7 nTPM

Respiratory ciliated cells	24.7 nTPM
Lung	24.8 nTPM
Bronchus	24.6 nTPM

Smooth muscle cells	21.4 nTPM
Bronchus	138.2 nTPM
Pancreas	19.5 nTPM
Ovary	14.9 nTPM
Breast	12.4 nTPM
Adipose tissue	8.5 nTPM
Esophagus	7.8 nTPM
Heart muscle	7.6 nTPM
Prostate	7.5 nTPM
Skin	6.6 nTPM
Endometrium	6.5 nTPM
Skeletal muscle	6.5 nTPM

T-cells	13.0 nTPM
Lymph node	25.6 nTPM
Stomach	17.6 nTPM
Breast	16.9 nTPM
Colon	15.7 nTPM
Bone marrow	14.6 nTPM
Spleen	13.8 nTPM
Kidney	13.7 nTPM
Adipose tissue	13.5 nTPM
Ovary	13.4 nTPM
Esophagus	13.1 nTPM
PBMC	12.4 nTPM
Skeletal muscle	10.0 nTPM
Liver	9.5 nTPM
Endometrium	9.3 nTPM
Lung	9.1 nTPM
Skin	8.8 nTPM
Prostate	4.7 nTPM

Basal squamous epithelial cells	19.4 nTPM
Esophagus	19.4 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Collecting duct cells	12.9 nTPM
Kidney	12.9 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Undifferentiated cells	19.4 nTPM
Rectum	24.9 nTPM
Small intestine	22.2 nTPM
Colon	11.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC