Single cell type - PPP2R2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP2R2B
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 2 regulatory subunit Bbeta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Late spermatids, Excitatory neurons, Inhibitory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (memory CD8 T-cell, gdT-cell, MAIT T-cell, naive CD8 T-cell, T-reg, NK-cell, memory CD4 T-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HaCaT, HDLM-2, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Late spermatids, Excitatory neurons, Inhibitory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PPP2R2B is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CNTN2	Contactin 2	0.7704	42
KLHL32	Kelch like family member 32	0.7676	42
STPG2	Sperm tail PG-rich repeat containing 2	0.7451	42
MVB12B	Multivesicular body subunit 12B	0.7112	42
SCGB2B2	Secretoglobin family 2B member 2	0.7010	42
MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2	0.6930	42
SIK3	SIK family kinase 3	0.6857	42
OTUD7A	OTU deubiquitinase 7A	0.6855	42
CTNNA3	Catenin alpha 3	0.6824	42
FGFR2	Fibroblast growth factor receptor 2	0.6767	42
NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	0.6729	42
TTLL11	Tubulin tyrosine ligase like 11	0.6679	42
DPYSL5	Dihydropyrimidinase like 5	0.6568	42
NHLH1	Nescient helix-loop-helix 1	0.6459	42
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.6455	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.5 nTPM
Breast	0.9 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	1.8 nTPM
Lung	1.8 nTPM

B-cells	0.3 nTPM
Breast	1.3 nTPM
Adipose tissue	1.0 nTPM
Spleen	0.3 nTPM
Lymph node	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	2.0 nTPM
Skin	2.0 nTPM

Dendritic cells	30.2 nTPM
Breast	49.2 nTPM
Adipose tissue	41.3 nTPM
PBMC	0.0 nTPM

Endothelial cells	2.0 nTPM
Eye	13.7 nTPM
Lung	6.2 nTPM
Testis	2.4 nTPM
Heart muscle	1.8 nTPM
Skin	1.7 nTPM
Liver	0.9 nTPM
Esophagus	0.9 nTPM
Breast	0.8 nTPM
Endometrium	0.1 nTPM
Skeletal muscle	0.1 nTPM
Placenta	0.0 nTPM
Prostate	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM

Fibroblasts	1.1 nTPM
Placenta	2.5 nTPM
Lung	2.2 nTPM
Skeletal muscle	2.0 nTPM
Skin	1.4 nTPM
Breast	1.3 nTPM
Prostate	1.2 nTPM
Heart muscle	1.0 nTPM
Esophagus	0.8 nTPM
Adipose tissue	0.1 nTPM
Ovary	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	1.4 nTPM
Breast	6.3 nTPM
Lung	4.0 nTPM
Testis	4.0 nTPM
Ovary	2.5 nTPM
Adipose tissue	1.4 nTPM
Bone marrow	1.2 nTPM
Skeletal muscle	0.6 nTPM
Endometrium	0.4 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	3.3 nTPM
Adipose tissue	13.6 nTPM
Bone marrow	1.7 nTPM
Spleen	0.6 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	0.1 nTPM
Bronchus	0.3 nTPM
Lung	0.0 nTPM

Smooth muscle cells	11.0 nTPM
Skin	31.1 nTPM
Esophagus	31.0 nTPM
Breast	25.8 nTPM
Prostate	10.3 nTPM
Heart muscle	9.4 nTPM
Adipose tissue	5.2 nTPM
Skeletal muscle	4.3 nTPM
Bronchus	2.8 nTPM
Endometrium	0.4 nTPM
Pancreas	0.2 nTPM
Ovary	0.1 nTPM

T-cells	31.0 nTPM
Stomach	49.3 nTPM
Spleen	46.5 nTPM
Liver	44.5 nTPM
Ovary	44.5 nTPM
Bone marrow	43.5 nTPM
Breast	40.3 nTPM
Esophagus	39.3 nTPM
Skeletal muscle	36.8 nTPM
Kidney	31.5 nTPM
Colon	29.5 nTPM
Adipose tissue	28.8 nTPM
Endometrium	19.7 nTPM
Skin	18.5 nTPM
Prostate	14.2 nTPM
PBMC	14.2 nTPM
Lung	13.6 nTPM
Lymph node	12.3 nTPM

Astrocytes	1539.0 nTPM
Brain	1539.0 nTPM

Cholangiocytes	10.0 nTPM
Liver	10.0 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Cone photoreceptor cells	150.1 nTPM
Eye	150.1 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC