Single cell type - ATAD2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATAD2
Gene descriptionⁱ Full gene name according to HGNC.	ATPase family AAA domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Spermatogonia, Erythroid cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes, Spermatogonia, Erythroid cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATAD2 is part of cluster 12 Non-specific - Cell cycle regulation with confidenceⁱ 1
294 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FANCI	FA complementation group I	0.7781	12
NCAPG	Non-SMC condensin I complex subunit G	0.7630	12
CENPE	Centromere protein E	0.7431	12
NCAPG2	Non-SMC condensin II complex subunit G2	0.7398	12
BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	0.7396	12
SKA1	Spindle and kinetochore associated complex subunit 1	0.7290	12
PRC1	Protein regulator of cytokinesis 1	0.7250	12
ASF1B	Anti-silencing function 1B histone chaperone	0.7249	12
KIF11	Kinesin family member 11	0.7233	12
CDCA8	Cell division cycle associated 8	0.7218	12
HMGB2	High mobility group box 2	0.7189	12
NDC80	NDC80 kinetochore complex component	0.7167	12
TOP2A	DNA topoisomerase II alpha	0.7162	12
FANCD2	FA complementation group D2	0.7078	12
RACGAP1	Rac GTPase activating protein 1	0.7073	12

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.8 nTPM
Adipose tissue	5.1 nTPM
Breast	4.5 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	11.0 nTPM
Lung	11.0 nTPM

Astrocytes	9.4 nTPM
Brain	9.4 nTPM

B-cells	18.5 nTPM
Liver	42.6 nTPM
Colon	25.5 nTPM
Adipose tissue	21.6 nTPM
PBMC	17.1 nTPM
Lymph node	16.7 nTPM
Spleen	15.3 nTPM
Stomach	15.0 nTPM
Bone marrow	14.7 nTPM
Breast	12.1 nTPM
Kidney	4.8 nTPM

Dendritic cells	15.3 nTPM
Adipose tissue	24.1 nTPM
Breast	21.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	9.6 nTPM
Lung	28.1 nTPM
Endometrium	15.6 nTPM
Eye	15.4 nTPM
Heart muscle	14.4 nTPM
Ovary	13.9 nTPM
Liver	8.2 nTPM
Pancreas	7.7 nTPM
Skeletal muscle	6.5 nTPM
Breast	6.1 nTPM
Prostate	5.1 nTPM
Testis	5.1 nTPM
Placenta	4.6 nTPM
Skin	2.7 nTPM
Esophagus	1.6 nTPM

Fibroblasts	17.1 nTPM
Ovary	39.3 nTPM
Prostate	37.6 nTPM
Lung	31.3 nTPM
Heart muscle	16.3 nTPM
Placenta	11.9 nTPM
Esophagus	10.3 nTPM
Stomach	8.9 nTPM
Skeletal muscle	8.7 nTPM
Breast	8.7 nTPM
Adipose tissue	8.2 nTPM
Skin	6.8 nTPM

Intestinal goblet cells	13.1 nTPM
Colon	19.3 nTPM
Small intestine	15.6 nTPM
Rectum	4.3 nTPM

Macrophages	11.7 nTPM
Endometrium	20.5 nTPM
Lung	18.2 nTPM
Esophagus	17.3 nTPM
Bone marrow	16.3 nTPM
Adipose tissue	15.6 nTPM
Stomach	14.7 nTPM
Ovary	13.6 nTPM
Breast	13.2 nTPM
Skeletal muscle	10.9 nTPM
Spleen	10.4 nTPM
Pancreas	7.7 nTPM
Testis	7.5 nTPM
Prostate	5.7 nTPM
Kidney	4.6 nTPM
PBMC	0.0 nTPM

Paneth cells	4.3 nTPM
Rectum	5.8 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	34.0 nTPM
Bone marrow	72.5 nTPM
Spleen	64.6 nTPM
Adipose tissue	21.3 nTPM
Stomach	11.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.4 nTPM
Lung	5.8 nTPM
Bronchus	4.9 nTPM

Smooth muscle cells	17.5 nTPM
Bronchus	40.7 nTPM
Endometrium	36.3 nTPM
Pancreas	29.7 nTPM
Ovary	23.1 nTPM
Prostate	13.8 nTPM
Breast	10.4 nTPM
Skeletal muscle	9.9 nTPM
Heart muscle	9.5 nTPM
Adipose tissue	9.1 nTPM
Skin	8.4 nTPM
Esophagus	1.5 nTPM

T-cells	22.8 nTPM
Esophagus	39.3 nTPM
Adipose tissue	36.4 nTPM
Skeletal muscle	31.6 nTPM
Colon	31.4 nTPM
Endometrium	30.4 nTPM
Bone marrow	24.5 nTPM
Breast	21.5 nTPM
Lymph node	21.4 nTPM
Spleen	20.8 nTPM
Ovary	20.1 nTPM
Lung	19.7 nTPM
Liver	18.9 nTPM
Skin	17.5 nTPM
PBMC	17.4 nTPM
Kidney	16.4 nTPM
Stomach	16.1 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	15.8 nTPM
Skin	15.8 nTPM

Basal prostatic cells	27.9 nTPM
Prostate	27.9 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Cholangiocytes	2.8 nTPM
Liver	2.8 nTPM

Undifferentiated cells	14.6 nTPM
Small intestine	20.7 nTPM
Rectum	11.7 nTPM
Colon	11.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC