Brain tissue expression of MX1 - Summary

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Human gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MX1
Human gene descriptionⁱ Full gene name according to HGNC.	MX dynamin like GTPase 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Mouse gene	No orthologous mouse gene.
Pig gene	ENSSSCG00000012077 (version 103)
Antibodies in assayⁱ The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.	HPA030918

HUMAN PROTEIN ATLAS INFORMATION
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (salivary gland)
	Human brain	Pig brain
Regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity	Low region specificity
Regional distributionⁱ The regional distribution category is based on mRNA expression detected above cut off or not in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. Brain expression for all species is based on data from HPA. The distribution categories include: detected in all, detected in many, detected in some, detected in single and not detected. The classification rules are the same used for the tissue distribution category. Read more	Detected in all	Detected in all
Cellular locationⁱ Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain. Read more	Soma in astrocytes.
Protein profileⁱ A summary of the overall protein localization across the analyzed brain tissue. The summary is based on manual annotation. Mouse brain profiles includes a more extensive summary of the protein location while summaries with only human protein profile are more limited and are based on imported data/images from the Tissue Atlas stainings that has undergone an additional brain-centric curation step. Read more	Weak-moderate intensity widespread astroglial immunostaining throughout the entire brain. Strongest in the lateral septum hippocampus and cerebral cortex molecular layer.

BRAIN RNA EXPRESSION

HUMAN

Cerebral cortex Hippocampal formation Amygdala Basal ganglia Thalamus Hypothalamus Midbrain Cerebellum Pons Medulla oblongata Spinal cord White matter Corpus callosum Expression Detection All organs	HPA Human brain datasetⁱ Normalized RNA expression levels (nTPM) shown for the 13 brain regions. Color coding is based on brain region and the bar shows the highest expression among the subregions included. To access sample data, click on region name or bar. Read more about normalized expression levels in Assays & Annotation.
CTX HPF AMY BG TH HY MB CB P M SC WM
Cerebral cortex Hippocampal formation Amygdala Basal ganglia Thalamus Hypothalamus Midbrain Cerebellum Pons Medulla oblongata Spinal cord White matter

COMPARISON BRAIN RNA EXPRESSION

GTEX AND FANTOM HUMAN BRAIN

GTEx Human brain RNA-Seq datasetⁱ

FANTOM5 Human brain CAGE datasetⁱ

PIG

HPA Pig brain RNA-Seq datasetⁱ

HUMAN BRAIN PROTEIN LOCATIONⁱ

Non curated brain data available in the Tissue Atlas.

MOUSE BRAIN PROTEIN LOCATIONⁱ

Protein profile	Weak-moderate intensity widespread astroglial immunostaining throughout the entire brain. Strongest in the lateral septum hippocampus and cerebral cortex molecular layer.
Cellular location	Soma in astrocytes.
Protein profile reliability	Approved based on HPA030918

HPA Mouse staining intesityⁱ


Selected annotations	Hypothalamus	Hypothalamus	Hippocampus	Cerebellum
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