Single cell type - CREB3L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CREB3L1
Gene descriptionⁱ Full gene name according to HGNC.	CAMP responsive element binding protein 3 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mucus-secreting cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Intestinal goblet cells, Glandular and luminal cells, Gastric mucus-secreting cells, Exocrine glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+, fHDF/TERT166, OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Intestinal goblet cells, Glandular and luminal cells, Gastric mucus-secreting cells, Exocrine glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CREB3L1 is part of cluster 27 Mucus-secreting cells - Mucin production with confidenceⁱ 1
121 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
STX19	Syntaxin 19	0.7700	27
CANT1	Calcium activated nucleotidase 1	0.7461	27
NPDC1	Neural proliferation, differentiation and control 1	0.7339	27
LRRC26	Leucine rich repeat containing 26	0.7322	27
PYCR1	Pyrroline-5-carboxylate reductase 1	0.6978	30
BEST2	Bestrophin 2	0.6932	27
SLC50A1	Solute carrier family 50 member 1	0.6872	30
KCTD14	Potassium channel tetramerization domain containing 14	0.6824	30
B3GNT6	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6	0.6813	27
LRRC31	Leucine rich repeat containing 31	0.6750	27
TPSG1	Tryptase gamma 1	0.6745	27
REP15	RAB15 effector protein	0.6629	27
ITLN1	Intelectin 1	0.6618	27
FCGBP	Fc fragment of IgG binding protein	0.6595	27
ST6GALNAC1	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	0.6562	27

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.3 nTPM
Adipose tissue	11.6 nTPM
Breast	9.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	46.4 nTPM
Lung	46.4 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	0.6 nTPM
Breast	2.6 nTPM
Stomach	1.8 nTPM
Colon	1.6 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.1 nTPM
Breast	0.4 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	9.0 nTPM
Skeletal muscle	50.8 nTPM
Ovary	45.1 nTPM
Heart muscle	7.7 nTPM
Endometrium	4.7 nTPM
Esophagus	4.7 nTPM
Prostate	4.0 nTPM
Skin	4.0 nTPM
Breast	2.7 nTPM
Testis	1.4 nTPM
Placenta	0.6 nTPM
Eye	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	49.4 nTPM
Placenta	210.1 nTPM
Ovary	73.4 nTPM
Skin	62.3 nTPM
Prostate	43.3 nTPM
Stomach	34.1 nTPM
Adipose tissue	31.7 nTPM
Esophagus	26.4 nTPM
Breast	21.7 nTPM
Skeletal muscle	21.3 nTPM
Lung	12.3 nTPM
Heart muscle	6.6 nTPM

Intestinal goblet cells	280.5 nTPM
Colon	311.6 nTPM
Rectum	269.5 nTPM
Small intestine	260.4 nTPM

Macrophages	1.0 nTPM
Endometrium	4.1 nTPM
Prostate	3.4 nTPM
Skeletal muscle	2.6 nTPM
Lung	1.8 nTPM
Breast	1.6 nTPM
Testis	0.6 nTPM
Ovary	0.2 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	59.8 nTPM
Rectum	98.3 nTPM
Small intestine	45.0 nTPM
Colon	36.2 nTPM

Plasma cells	0.2 nTPM
Stomach	0.9 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	3.6 nTPM
Lung	5.8 nTPM
Bronchus	1.4 nTPM

Smooth muscle cells	29.3 nTPM
Pancreas	252.6 nTPM
Bronchus	36.0 nTPM
Endometrium	8.0 nTPM
Ovary	6.1 nTPM
Skin	5.2 nTPM
Prostate	4.1 nTPM
Skeletal muscle	3.2 nTPM
Adipose tissue	3.1 nTPM
Heart muscle	1.5 nTPM
Esophagus	1.5 nTPM
Breast	1.0 nTPM

T-cells	1.8 nTPM
Endometrium	13.6 nTPM
Prostate	4.7 nTPM
Skin	3.6 nTPM
Lung	3.0 nTPM
Colon	1.4 nTPM
Stomach	1.4 nTPM
Skeletal muscle	1.3 nTPM
Breast	0.7 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal prostatic cells	44.4 nTPM
Prostate	44.4 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cytotrophoblasts	1.2 nTPM
Placenta	1.2 nTPM

Undifferentiated cells	57.7 nTPM
Rectum	91.5 nTPM
Colon	48.8 nTPM
Small intestine	32.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC