Single cell type - LDLRAP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LDLRAP1
Gene descriptionⁱ Full gene name according to HGNC.	Low density lipoprotein receptor adaptor protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Horizontal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Horizontal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LDLRAP1 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LAT	Linker for activation of T cells	0.8051	63
GRAP2	GRB2 related adaptor protein 2	0.7621	51
EDAR	Ectodysplasin A receptor	0.6770	51
CCND3	Cyclin D3	0.6672	51
SUSD3	Sushi domain containing 3	0.6519	32
TUBB1	Tubulin beta 1 class VI	0.6484	51
LY6G6F	Lymphocyte antigen 6 family member G6F	0.6467	51
CMTM5	CKLF like MARVEL transmembrane domain containing 5	0.6467	51
RGS10	Regulator of G protein signaling 10	0.6459	51
PF4	Platelet factor 4	0.6451	51
ALOX12	Arachidonate 12-lipoxygenase, 12S type	0.6439	51
SLFN14	Schlafen family member 14	0.6434	51
R3HDM4	R3H domain containing 4	0.6429	51
GP1BA	Glycoprotein Ib platelet subunit alpha	0.6425	51
PPBP	Pro-platelet basic protein	0.6423	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	9.8 nTPM
Breast	11.9 nTPM
Adipose tissue	7.8 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	11.0 nTPM
Lung	11.0 nTPM

Astrocytes	2.6 nTPM
Brain	2.6 nTPM

B-cells	11.5 nTPM
Liver	35.6 nTPM
Breast	16.0 nTPM
Kidney	14.3 nTPM
PBMC	14.3 nTPM
Bone marrow	9.0 nTPM
Adipose tissue	8.5 nTPM
Lymph node	5.3 nTPM
Spleen	4.9 nTPM
Colon	4.8 nTPM
Stomach	2.2 nTPM

Dendritic cells	13.3 nTPM
Breast	18.2 nTPM
PBMC	12.0 nTPM
Adipose tissue	9.8 nTPM

Endothelial cells	10.8 nTPM
Ovary	22.2 nTPM
Pancreas	19.3 nTPM
Prostate	13.6 nTPM
Liver	12.8 nTPM
Placenta	11.3 nTPM
Skeletal muscle	11.0 nTPM
Breast	10.7 nTPM
Eye	10.5 nTPM
Skin	8.3 nTPM
Testis	8.0 nTPM
Esophagus	7.8 nTPM
Endometrium	7.3 nTPM
Heart muscle	4.9 nTPM
Lung	3.1 nTPM

Fibroblasts	8.9 nTPM
Placenta	27.7 nTPM
Skeletal muscle	12.7 nTPM
Ovary	12.7 nTPM
Skin	8.4 nTPM
Heart muscle	7.9 nTPM
Esophagus	7.7 nTPM
Breast	6.9 nTPM
Adipose tissue	6.0 nTPM
Prostate	5.5 nTPM
Stomach	1.5 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	23.9 nTPM
Rectum	29.3 nTPM
Colon	24.3 nTPM
Small intestine	18.2 nTPM

Macrophages	23.7 nTPM
PBMC	286.4 nTPM
Breast	10.2 nTPM
Kidney	8.3 nTPM
Prostate	8.1 nTPM
Ovary	7.9 nTPM
Lung	7.5 nTPM
Pancreas	5.1 nTPM
Skeletal muscle	4.1 nTPM
Testis	4.0 nTPM
Endometrium	3.8 nTPM
Adipose tissue	3.2 nTPM
Stomach	2.9 nTPM
Spleen	2.1 nTPM
Bone marrow	1.2 nTPM
Esophagus	0.0 nTPM

Paneth cells	23.4 nTPM
Rectum	37.3 nTPM
Small intestine	26.3 nTPM
Colon	6.5 nTPM

Plasma cells	19.3 nTPM
Bone marrow	33.0 nTPM
Spleen	26.7 nTPM
Stomach	24.4 nTPM
Adipose tissue	12.2 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	6.1 nTPM
Bronchus	9.3 nTPM
Lung	2.9 nTPM

Smooth muscle cells	9.1 nTPM
Ovary	17.0 nTPM
Adipose tissue	13.8 nTPM
Breast	11.7 nTPM
Skeletal muscle	10.8 nTPM
Pancreas	9.0 nTPM
Bronchus	8.6 nTPM
Skin	8.0 nTPM
Heart muscle	7.9 nTPM
Prostate	7.2 nTPM
Endometrium	4.1 nTPM
Esophagus	1.5 nTPM

T-cells	28.7 nTPM
PBMC	109.7 nTPM
Lymph node	55.2 nTPM
Ovary	44.5 nTPM
Spleen	38.5 nTPM
Kidney	38.3 nTPM
Breast	33.5 nTPM
Bone marrow	30.3 nTPM
Liver	27.6 nTPM
Adipose tissue	20.3 nTPM
Skeletal muscle	18.9 nTPM
Prostate	14.2 nTPM
Colon	12.8 nTPM
Stomach	12.3 nTPM
Skin	11.9 nTPM
Endometrium	9.9 nTPM
Lung	9.1 nTPM
Esophagus	0.0 nTPM

Basal prostatic cells	20.6 nTPM
Prostate	20.6 nTPM

Basal respiratory cells	21.5 nTPM
Bronchus	21.5 nTPM

Basal squamous epithelial cells	15.4 nTPM
Esophagus	15.4 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Undifferentiated cells	22.0 nTPM
Colon	24.8 nTPM
Rectum	24.2 nTPM
Small intestine	17.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC