Single cell type - ABHD3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABHD3
Gene descriptionⁱ Full gene name according to HGNC.	Abhydrolase domain containing 3, phospholipase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Paneth cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (REH, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Paneth cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABHD3 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLCA4	Chloride channel accessory 4	0.8626	53
CD177	CD177 molecule	0.8419	53
TRIM31	Tripartite motif containing 31	0.8301	53
CEACAM7	CEA cell adhesion molecule 7	0.8285	53
AQP8	Aquaporin 8	0.8270	53
SIRT6	Sirtuin 6	0.8199	53
MIER3	MIER family member 3	0.8176	53
MYO15B	Myosin XVB	0.8161	53
GCNT3	Glucosaminyl (N-acetyl) transferase 3, mucin type	0.8156	53
LYPD8	LY6/PLAUR domain containing 8	0.8132	53
RSAD2	Radical S-adenosyl methionine domain containing 2	0.8120	53
CLDN23	Claudin 23	0.8074	53
CEACAM1	CEA cell adhesion molecule 1	0.8053	53
MS4A12	Membrane spanning 4-domains A12	0.8025	53
CEACAM5	CEA cell adhesion molecule 5	0.7989	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.4 nTPM
Adipose tissue	9.1 nTPM
Breast	7.6 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	9.3 nTPM
Lung	9.3 nTPM

Astrocytes	42.4 nTPM
Brain	42.4 nTPM

B-cells	22.8 nTPM
Liver	45.0 nTPM
Breast	29.4 nTPM
Lymph node	22.4 nTPM
Stomach	22.3 nTPM
Colon	19.2 nTPM
Kidney	19.0 nTPM
Bone marrow	18.8 nTPM
Adipose tissue	18.0 nTPM
PBMC	17.1 nTPM
Spleen	16.6 nTPM

Dendritic cells	24.4 nTPM
Breast	40.1 nTPM
Adipose tissue	33.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	9.5 nTPM
Prostate	18.3 nTPM
Heart muscle	17.8 nTPM
Eye	14.6 nTPM
Skin	14.1 nTPM
Endometrium	10.2 nTPM
Lung	9.3 nTPM
Esophagus	9.3 nTPM
Liver	9.2 nTPM
Skeletal muscle	9.2 nTPM
Breast	7.1 nTPM
Ovary	5.8 nTPM
Placenta	5.7 nTPM
Testis	2.4 nTPM
Pancreas	0.0 nTPM

Fibroblasts	10.6 nTPM
Prostate	24.7 nTPM
Skin	23.5 nTPM
Breast	11.5 nTPM
Heart muscle	10.5 nTPM
Skeletal muscle	9.3 nTPM
Placenta	9.0 nTPM
Ovary	8.8 nTPM
Adipose tissue	8.8 nTPM
Esophagus	4.7 nTPM
Lung	3.4 nTPM
Stomach	3.0 nTPM

Intestinal goblet cells	57.9 nTPM
Colon	65.7 nTPM
Rectum	63.0 nTPM
Small intestine	45.0 nTPM

Macrophages	26.4 nTPM
Prostate	67.6 nTPM
Kidney	44.7 nTPM
Spleen	37.4 nTPM
Bone marrow	31.2 nTPM
Breast	26.2 nTPM
Adipose tissue	23.8 nTPM
Skeletal muscle	22.7 nTPM
Esophagus	22.0 nTPM
Ovary	21.3 nTPM
Endometrium	21.2 nTPM
Testis	18.6 nTPM
Lung	15.3 nTPM
Pancreas	15.3 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM

Paneth cells	126.6 nTPM
Colon	283.3 nTPM
Rectum	51.3 nTPM
Small intestine	45.0 nTPM

Plasma cells	45.5 nTPM
Esophagus	61.7 nTPM
Stomach	48.6 nTPM
Spleen	45.9 nTPM
Bone marrow	39.5 nTPM
Adipose tissue	31.6 nTPM

Respiratory ciliated cells	40.8 nTPM
Bronchus	64.1 nTPM
Lung	17.5 nTPM

Smooth muscle cells	13.2 nTPM
Heart muscle	25.2 nTPM
Prostate	17.8 nTPM
Adipose tissue	16.3 nTPM
Skin	16.0 nTPM
Endometrium	13.7 nTPM
Bronchus	12.2 nTPM
Breast	12.0 nTPM
Pancreas	10.1 nTPM
Skeletal muscle	10.1 nTPM
Esophagus	7.8 nTPM
Ovary	4.1 nTPM

T-cells	38.3 nTPM
Prostate	94.7 nTPM
Kidney	69.8 nTPM
Colon	47.5 nTPM
Skin	42.8 nTPM
Ovary	40.0 nTPM
Breast	39.9 nTPM
Liver	35.2 nTPM
Spleen	34.7 nTPM
PBMC	33.5 nTPM
Esophagus	32.8 nTPM
Adipose tissue	31.6 nTPM
Endometrium	31.3 nTPM
Skeletal muscle	31.1 nTPM
Bone marrow	28.7 nTPM
Stomach	22.9 nTPM
Lymph node	21.5 nTPM
Lung	13.6 nTPM

Basal keratinocytes	33.4 nTPM
Skin	33.4 nTPM

Basal respiratory cells	21.6 nTPM
Bronchus	21.6 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Cone photoreceptor cells	47.9 nTPM
Eye	47.9 nTPM

Undifferentiated cells	36.8 nTPM
Colon	59.4 nTPM
Rectum	30.4 nTPM
Small intestine	20.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC