Single cell type - AHCYL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AHCYL2
Gene descriptionⁱ Full gene name according to HGNC.	Adenosylhomocysteinase like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Astrocytes, Distal enterocytes, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Astrocytes, Distal enterocytes, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AHCYL2 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
OR2F1	Olfactory receptor family 2 subfamily F member 1	0.8151	53
SLC26A3	Solute carrier family 26 member 3	0.7456	53
MS4A12	Membrane spanning 4-domains A12	0.7195	53
CEACAM7	CEA cell adhesion molecule 7	0.7076	53
AQP8	Aquaporin 8	0.6991	53
CD177	CD177 molecule	0.6900	53
APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	0.6896	53
SIRT6	Sirtuin 6	0.6889	53
SCNN1B	Sodium channel epithelial 1 subunit beta	0.6858	53
CLCN2	Chloride voltage-gated channel 2	0.6852	53
GPA33	Glycoprotein A33	0.6814	53
HRCT1	Histidine rich carboxyl terminus 1	0.6797	53
CASP7	Caspase 7	0.6747	53
TMEM54	Transmembrane protein 54	0.6709	53
ETHE1	ETHE1 persulfide dioxygenase	0.6659	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.7 nTPM
Adipose tissue	5.6 nTPM
Breast	3.9 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	98.6 nTPM
Lung	98.6 nTPM

B-cells	9.3 nTPM
Lymph node	18.9 nTPM
Bone marrow	16.4 nTPM
Spleen	16.2 nTPM
Stomach	11.8 nTPM
Breast	10.7 nTPM
Adipose tissue	5.5 nTPM
Kidney	4.8 nTPM
Colon	3.2 nTPM
PBMC	2.8 nTPM
Liver	2.6 nTPM

Basal keratinocytes	15.6 nTPM
Skin	15.6 nTPM

Dendritic cells	2.2 nTPM
Breast	3.6 nTPM
Adipose tissue	3.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	5.2 nTPM
Heart muscle	19.7 nTPM
Eye	7.3 nTPM
Liver	7.3 nTPM
Esophagus	5.8 nTPM
Skeletal muscle	5.6 nTPM
Testis	5.4 nTPM
Skin	4.4 nTPM
Breast	4.0 nTPM
Endometrium	3.4 nTPM
Lung	3.1 nTPM
Ovary	2.9 nTPM
Placenta	2.2 nTPM
Prostate	1.2 nTPM
Pancreas	0.0 nTPM

Fibroblasts	3.6 nTPM
Esophagus	5.7 nTPM
Skeletal muscle	4.4 nTPM
Stomach	4.4 nTPM
Skin	4.2 nTPM
Adipose tissue	4.1 nTPM
Prostate	3.8 nTPM
Lung	3.4 nTPM
Breast	3.2 nTPM
Placenta	3.0 nTPM
Ovary	2.3 nTPM
Heart muscle	0.5 nTPM

Intestinal goblet cells	32.9 nTPM
Rectum	52.0 nTPM
Colon	37.8 nTPM
Small intestine	9.0 nTPM

Macrophages	7.3 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM
Kidney	12.0 nTPM
Lung	9.6 nTPM
Spleen	9.3 nTPM
Bone marrow	8.7 nTPM
Adipose tissue	7.9 nTPM
Skeletal muscle	7.2 nTPM
Esophagus	6.3 nTPM
Endometrium	6.2 nTPM
Breast	5.0 nTPM
Testis	4.6 nTPM
Ovary	4.2 nTPM
Prostate	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	71.8 nTPM
Colon	177.9 nTPM
Rectum	33.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	7.4 nTPM
Stomach	13.3 nTPM
Esophagus	12.3 nTPM
Bone marrow	5.0 nTPM
Spleen	4.5 nTPM
Adipose tissue	1.9 nTPM

Respiratory ciliated cells	8.7 nTPM
Bronchus	11.6 nTPM
Lung	5.8 nTPM

Smooth muscle cells	4.3 nTPM
Bronchus	13.3 nTPM
Esophagus	7.8 nTPM
Skeletal muscle	5.7 nTPM
Endometrium	3.8 nTPM
Adipose tissue	3.3 nTPM
Ovary	3.2 nTPM
Skin	2.8 nTPM
Breast	2.7 nTPM
Heart muscle	2.6 nTPM
Prostate	1.3 nTPM
Pancreas	1.2 nTPM

T-cells	7.3 nTPM
Lymph node	19.5 nTPM
Spleen	13.7 nTPM
Stomach	13.2 nTPM
Esophagus	13.1 nTPM
Bone marrow	11.0 nTPM
Skeletal muscle	8.2 nTPM
Skin	7.4 nTPM
Colon	7.1 nTPM
Adipose tissue	5.2 nTPM
Endometrium	5.0 nTPM
Ovary	4.5 nTPM
Breast	4.3 nTPM
PBMC	3.4 nTPM
Lung	3.0 nTPM
Liver	2.8 nTPM
Kidney	2.7 nTPM
Prostate	0.0 nTPM

Astrocytes	567.4 nTPM
Brain	567.4 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Cytotrophoblasts	12.5 nTPM
Placenta	12.5 nTPM

Early spermatids	61.7 nTPM
Testis	61.7 nTPM

Undifferentiated cells	46.1 nTPM
Rectum	63.5 nTPM
Colon	59.2 nTPM
Small intestine	15.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC