Single cell type - PINK1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PINK1
Gene descriptionⁱ Full gene name according to HGNC.	PTEN induced kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PINK1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC25A23	Solute carrier family 25 member 23	0.4996	53
HS1BP3	HCLS1 binding protein 3	0.4879	25
PEX11A	Peroxisomal biogenesis factor 11 alpha	0.4809	53
TEX261	Testis expressed 261	0.4659	46
COPRS	Coordinator of PRMT5 and differentiation stimulator	0.4622	66
CTDSP2	CTD small phosphatase 2	0.4510	53
ACOT8	Acyl-CoA thioesterase 8	0.4502	53
RNF6	Ring finger protein 6	0.4500	31
TUSC1	Tumor suppressor candidate 1	0.4435	66
VTI1B	Vesicle transport through interaction with t-SNAREs 1B	0.4416	25
TCEA2	Transcription elongation factor A2	0.4397	39
OPTN	Optineurin	0.4381	31
CPTP	Ceramide-1-phosphate transfer protein	0.4339	25
PRDX6	Peroxiredoxin 6	0.4330	53
KRTAP13-2	Keratin associated protein 13-2	0.4299	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.7 nTPM
Breast	44.9 nTPM
Adipose tissue	32.4 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	19.2 nTPM
Lung	19.2 nTPM

Astrocytes	16.3 nTPM
Brain	16.3 nTPM

B-cells	9.1 nTPM
Breast	24.1 nTPM
Liver	18.5 nTPM
Kidney	9.5 nTPM
Lymph node	7.7 nTPM
Colon	6.4 nTPM
Adipose tissue	6.0 nTPM
Bone marrow	5.7 nTPM
Spleen	5.5 nTPM
Stomach	4.5 nTPM
PBMC	2.8 nTPM

Dendritic cells	9.2 nTPM
Adipose tissue	12.3 nTPM
Breast	11.3 nTPM
PBMC	4.0 nTPM

Endothelial cells	48.5 nTPM
Liver	138.5 nTPM
Testis	102.5 nTPM
Eye	82.5 nTPM
Prostate	76.8 nTPM
Ovary	49.0 nTPM
Endometrium	48.3 nTPM
Breast	39.4 nTPM
Skeletal muscle	36.8 nTPM
Placenta	35.8 nTPM
Skin	22.8 nTPM
Esophagus	20.1 nTPM
Pancreas	19.3 nTPM
Lung	6.2 nTPM
Heart muscle	0.8 nTPM

Fibroblasts	27.4 nTPM
Skeletal muscle	41.1 nTPM
Breast	39.5 nTPM
Adipose tissue	37.7 nTPM
Skin	36.5 nTPM
Prostate	34.6 nTPM
Esophagus	31.9 nTPM
Ovary	27.5 nTPM
Placenta	23.2 nTPM
Stomach	22.3 nTPM
Lung	3.4 nTPM
Heart muscle	3.3 nTPM

Intestinal goblet cells	30.2 nTPM
Rectum	34.2 nTPM
Small intestine	28.5 nTPM
Colon	27.9 nTPM

Macrophages	22.7 nTPM
Ovary	67.4 nTPM
Prostate	36.7 nTPM
Pancreas	35.7 nTPM
Kidney	27.2 nTPM
Testis	23.8 nTPM
Skeletal muscle	22.2 nTPM
Stomach	20.5 nTPM
Bone marrow	20.0 nTPM
Spleen	19.7 nTPM
Breast	17.2 nTPM
Lung	14.2 nTPM
Adipose tissue	13.9 nTPM
Esophagus	11.0 nTPM
Endometrium	10.9 nTPM
PBMC	0.0 nTPM

Paneth cells	67.9 nTPM
Colon	115.3 nTPM
Small intestine	48.8 nTPM
Rectum	39.7 nTPM

Plasma cells	27.0 nTPM
Stomach	38.6 nTPM
Esophagus	30.7 nTPM
Spleen	30.6 nTPM
Adipose tissue	20.0 nTPM
Bone marrow	14.8 nTPM

Respiratory ciliated cells	7.6 nTPM
Bronchus	13.7 nTPM
Lung	1.5 nTPM

Smooth muscle cells	32.2 nTPM
Breast	53.8 nTPM
Ovary	51.1 nTPM
Prostate	50.6 nTPM
Pancreas	43.2 nTPM
Skeletal muscle	38.1 nTPM
Skin	34.9 nTPM
Adipose tissue	30.5 nTPM
Esophagus	29.4 nTPM
Endometrium	17.0 nTPM
Bronchus	4.6 nTPM
Heart muscle	0.6 nTPM

T-cells	10.6 nTPM
Kidney	17.1 nTPM
Ovary	15.6 nTPM
Skin	15.2 nTPM
Liver	14.8 nTPM
Prostate	14.2 nTPM
Skeletal muscle	13.4 nTPM
Lymph node	13.4 nTPM
Breast	13.4 nTPM
Adipose tissue	12.8 nTPM
Endometrium	8.9 nTPM
Bone marrow	8.4 nTPM
Spleen	8.1 nTPM
Colon	7.6 nTPM
PBMC	7.4 nTPM
Stomach	5.4 nTPM
Lung	4.5 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	15.7 nTPM
Skin	15.7 nTPM

Basal prostatic cells	36.0 nTPM
Prostate	36.0 nTPM

Basal respiratory cells	7.9 nTPM
Bronchus	7.9 nTPM

Cholangiocytes	37.1 nTPM
Liver	37.1 nTPM

Undifferentiated cells	24.4 nTPM
Rectum	33.6 nTPM
Colon	20.1 nTPM
Small intestine	19.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC