Single cell type - GART - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GART
Gene descriptionⁱ Full gene name according to HGNC.	Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GART is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ABCE1	ATP binding cassette subfamily E member 1	0.6924	39
NIFK	Nucleolar protein interacting with the FHA domain of MKI67	0.6829	39
NOC2L	NOC2 like nucleolar associated transcriptional repressor	0.6086	39
BYSL	Bystin like	0.5966	39
ILF3	Interleukin enhancer binding factor 3	0.5856	39
NIP7	Nucleolar pre-rRNA processing protein NIP7	0.5822	39
SEH1L	SEH1 like nucleoporin	0.5798	39
NOP14	NOP14 nucleolar protein	0.5667	10
PAICS	Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	0.5586	12
DKC1	Dyskerin pseudouridine synthase 1	0.5558	39
GPATCH4	G-patch domain containing 4	0.5502	39
NOC3L	NOC3 like DNA replication regulator	0.5482	59
ZNF121	Zinc finger protein 121	0.5462	22
NUP160	Nucleoporin 160	0.5339	52
NAT10	N-acetyltransferase 10	0.5329	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.1 nTPM
Adipose tissue	23.0 nTPM
Breast	19.1 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	19.8 nTPM
Lung	19.8 nTPM

Astrocytes	17.3 nTPM
Brain	17.3 nTPM

B-cells	30.1 nTPM
Bone marrow	47.4 nTPM
Spleen	41.5 nTPM
Kidney	33.4 nTPM
Liver	32.5 nTPM
Lymph node	32.3 nTPM
Stomach	32.2 nTPM
PBMC	24.3 nTPM
Adipose tissue	22.5 nTPM
Colon	19.2 nTPM
Breast	16.0 nTPM

Dendritic cells	21.8 nTPM
PBMC	27.9 nTPM
Adipose tissue	21.7 nTPM
Breast	15.7 nTPM

Endothelial cells	21.9 nTPM
Prostate	39.8 nTPM
Heart muscle	31.6 nTPM
Pancreas	27.0 nTPM
Endometrium	25.2 nTPM
Lung	24.9 nTPM
Placenta	21.6 nTPM
Esophagus	21.2 nTPM
Ovary	20.7 nTPM
Skin	19.1 nTPM
Liver	16.5 nTPM
Skeletal muscle	16.1 nTPM
Breast	15.2 nTPM
Testis	14.2 nTPM
Eye	12.9 nTPM

Fibroblasts	27.2 nTPM
Prostate	54.0 nTPM
Lung	53.6 nTPM
Ovary	37.3 nTPM
Stomach	23.7 nTPM
Heart muscle	22.4 nTPM
Esophagus	21.7 nTPM
Adipose tissue	20.5 nTPM
Placenta	18.8 nTPM
Skeletal muscle	17.2 nTPM
Skin	16.6 nTPM
Breast	13.1 nTPM

Intestinal goblet cells	17.1 nTPM
Rectum	19.4 nTPM
Colon	17.2 nTPM
Small intestine	14.6 nTPM

Macrophages	17.0 nTPM
Lung	21.9 nTPM
Endometrium	21.9 nTPM
Kidney	21.1 nTPM
Testis	20.9 nTPM
Ovary	20.2 nTPM
Bone marrow	20.0 nTPM
Spleen	19.7 nTPM
Esophagus	18.9 nTPM
Skeletal muscle	16.1 nTPM
Breast	15.4 nTPM
Adipose tissue	14.8 nTPM
PBMC	13.6 nTPM
Pancreas	12.8 nTPM
Prostate	9.1 nTPM
Stomach	8.8 nTPM

Paneth cells	12.7 nTPM
Rectum	23.5 nTPM
Small intestine	11.3 nTPM
Colon	3.3 nTPM

Plasma cells	22.7 nTPM
Bone marrow	42.9 nTPM
Spleen	30.5 nTPM
Stomach	20.0 nTPM
Adipose tissue	14.2 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	17.8 nTPM
Bronchus	19.6 nTPM
Lung	16.0 nTPM

Smooth muscle cells	23.9 nTPM
Prostate	42.5 nTPM
Pancreas	38.9 nTPM
Adipose tissue	30.9 nTPM
Skin	24.7 nTPM
Endometrium	24.7 nTPM
Ovary	22.8 nTPM
Skeletal muscle	20.7 nTPM
Esophagus	20.1 nTPM
Breast	17.4 nTPM
Bronchus	11.4 nTPM
Heart muscle	9.0 nTPM

T-cells	21.2 nTPM
Lung	34.9 nTPM
Bone marrow	33.2 nTPM
Lymph node	31.5 nTPM
Kidney	29.4 nTPM
Spleen	25.9 nTPM
PBMC	23.4 nTPM
Adipose tissue	22.7 nTPM
Stomach	22.7 nTPM
Endometrium	20.4 nTPM
Colon	19.0 nTPM
Skin	18.8 nTPM
Liver	17.9 nTPM
Breast	16.3 nTPM
Skeletal muscle	14.4 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM
Ovary	6.7 nTPM

Basal keratinocytes	46.0 nTPM
Skin	46.0 nTPM

Basal prostatic cells	50.3 nTPM
Prostate	50.3 nTPM

Basal respiratory cells	34.1 nTPM
Bronchus	34.1 nTPM

Basal squamous epithelial cells	38.1 nTPM
Esophagus	38.1 nTPM

Undifferentiated cells	24.1 nTPM
Colon	27.3 nTPM
Small intestine	24.1 nTPM
Rectum	21.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC