Single cell type - RSPRY1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RSPRY1
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger and SPRY domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RSPRY1 is part of cluster 29 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C20orf173	Chromosome 20 open reading frame 173	0.6783	29
SRRM5	Serine/arginine repetitive matrix 5	0.6762	29
FAM170B	Family with sequence similarity 170 member B	0.6734	29
TEKT5	Tektin 5	0.6721	29
C10orf120	Chromosome 10 open reading frame 120	0.6695	29
DNAJB7	DnaJ heat shock protein family (Hsp40) member B7	0.6682	29
IQCF6	IQ motif containing F6	0.6673	29
LRRC72	Leucine rich repeat containing 72	0.6635	29
CCIN	Calicin	0.6622	29
PRSS58	Serine protease 58	0.6612	29
FAM71A	Family with sequence similarity 71 member A	0.6589	29
FAM71B	Family with sequence similarity 71 member B	0.6584	29
DCDC2C	Doublecortin domain containing 2C	0.6581	29
CCDC185	Coiled-coil domain containing 185	0.6572	29
WFDC11	WAP four-disulfide core domain 11	0.6563	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.6 nTPM
Adipose tissue	23.7 nTPM
Breast	13.6 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	13.1 nTPM
Lung	13.1 nTPM

Astrocytes	22.5 nTPM
Brain	22.5 nTPM

B-cells	24.0 nTPM
Colon	33.5 nTPM
Lymph node	30.4 nTPM
Spleen	28.0 nTPM
PBMC	24.3 nTPM
Adipose tissue	24.0 nTPM
Stomach	23.6 nTPM
Liver	21.3 nTPM
Bone marrow	21.3 nTPM
Kidney	19.0 nTPM
Breast	14.7 nTPM

Dendritic cells	18.9 nTPM
Adipose tissue	25.1 nTPM
PBMC	16.0 nTPM
Breast	15.7 nTPM

Endothelial cells	23.8 nTPM
Pancreas	38.6 nTPM
Skin	34.9 nTPM
Esophagus	30.3 nTPM
Endometrium	28.6 nTPM
Prostate	28.1 nTPM
Ovary	25.4 nTPM
Liver	22.9 nTPM
Lung	21.8 nTPM
Placenta	19.9 nTPM
Heart muscle	18.7 nTPM
Breast	17.8 nTPM
Skeletal muscle	17.4 nTPM
Testis	16.3 nTPM
Eye	12.9 nTPM

Fibroblasts	29.2 nTPM
Prostate	42.2 nTPM
Skin	37.2 nTPM
Lung	34.7 nTPM
Adipose tissue	30.9 nTPM
Placenta	29.6 nTPM
Esophagus	27.7 nTPM
Stomach	26.7 nTPM
Breast	25.1 nTPM
Skeletal muscle	24.8 nTPM
Ovary	21.6 nTPM
Heart muscle	21.2 nTPM

Intestinal goblet cells	32.9 nTPM
Colon	38.6 nTPM
Rectum	31.6 nTPM
Small intestine	28.7 nTPM

Macrophages	19.8 nTPM
Spleen	38.4 nTPM
Bone marrow	28.7 nTPM
Adipose tissue	26.2 nTPM
Stomach	23.5 nTPM
Ovary	23.3 nTPM
Kidney	21.9 nTPM
Pancreas	20.4 nTPM
Esophagus	20.4 nTPM
Testis	18.6 nTPM
Endometrium	18.5 nTPM
Skeletal muscle	17.3 nTPM
Breast	13.7 nTPM
Lung	13.5 nTPM
Prostate	12.6 nTPM
PBMC	0.0 nTPM

Paneth cells	15.5 nTPM
Rectum	24.1 nTPM
Small intestine	22.5 nTPM
Colon	0.0 nTPM

Plasma cells	21.2 nTPM
Stomach	23.8 nTPM
Bone marrow	23.0 nTPM
Spleen	20.5 nTPM
Adipose tissue	20.0 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	23.3 nTPM
Bronchus	30.6 nTPM
Lung	16.0 nTPM

Smooth muscle cells	25.2 nTPM
Heart muscle	46.5 nTPM
Bronchus	29.1 nTPM
Ovary	28.7 nTPM
Endometrium	27.0 nTPM
Prostate	26.3 nTPM
Skin	25.5 nTPM
Pancreas	24.4 nTPM
Adipose tissue	22.8 nTPM
Esophagus	18.6 nTPM
Skeletal muscle	15.7 nTPM
Breast	13.0 nTPM

T-cells	21.8 nTPM
Colon	33.2 nTPM
Esophagus	32.8 nTPM
Adipose tissue	29.0 nTPM
Lymph node	28.0 nTPM
Stomach	27.9 nTPM
Spleen	24.9 nTPM
Skin	21.6 nTPM
Liver	20.5 nTPM
PBMC	20.3 nTPM
Kidney	19.8 nTPM
Bone marrow	19.6 nTPM
Skeletal muscle	18.7 nTPM
Endometrium	18.5 nTPM
Lung	16.7 nTPM
Breast	16.5 nTPM
Prostate	14.2 nTPM
Ovary	8.9 nTPM

Basal keratinocytes	34.0 nTPM
Skin	34.0 nTPM

Basal prostatic cells	21.0 nTPM
Prostate	21.0 nTPM

Basal respiratory cells	27.5 nTPM
Bronchus	27.5 nTPM

Basal squamous epithelial cells	38.7 nTPM
Esophagus	38.7 nTPM

Undifferentiated cells	23.5 nTPM
Small intestine	24.5 nTPM
Rectum	24.0 nTPM
Colon	22.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC