Single cell type - ABCG1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABCG1
Gene descriptionⁱ Full gene name according to HGNC.	ATP binding cassette subfamily G member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells, Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTCEpi, JURKAT, MCF7, MOLT-4, OE19, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABCG1 is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC24A1	Solute carrier family 24 member 1	0.6321	46
SLC4A7	Solute carrier family 4 member 7	0.6217	9
CABP4	Calcium binding protein 4	0.6012	46
GNB1	G protein subunit beta 1	0.6001	46
CNGB1	Cyclic nucleotide gated channel subunit beta 1	0.5971	46
PDE6B	Phosphodiesterase 6B	0.5963	46
PDE6A	Phosphodiesterase 6A	0.5957	46
ZFYVE26	Zinc finger FYVE-type containing 26	0.5956	46
RAX2	Retina and anterior neural fold homeobox 2	0.5929	46
KCNJ14	Potassium inwardly rectifying channel subfamily J member 14	0.5915	46
ZMYND19	Zinc finger MYND-type containing 19	0.5898	46
PRPH2	Peripherin 2	0.5891	46
OR5P2	Olfactory receptor family 5 subfamily P member 2	0.5846	46
ADD1	Adducin 1	0.5827	46
NR2E3	Nuclear receptor subfamily 2 group E member 3	0.5815	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.2 nTPM
Adipose tissue	50.7 nTPM
Breast	25.6 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	8.2 nTPM
Lung	8.2 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	21.3 nTPM
Lymph node	73.5 nTPM
Stomach	47.7 nTPM
Adipose tissue	21.6 nTPM
PBMC	18.6 nTPM
Bone marrow	13.9 nTPM
Spleen	10.7 nTPM
Colon	9.6 nTPM
Breast	6.6 nTPM
Liver	6.3 nTPM
Kidney	4.8 nTPM

Dendritic cells	7.0 nTPM
Adipose tissue	12.6 nTPM
Breast	8.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	33.8 nTPM
Skin	54.0 nTPM
Pancreas	50.2 nTPM
Ovary	41.3 nTPM
Liver	41.2 nTPM
Testis	39.7 nTPM
Eye	34.8 nTPM
Prostate	32.2 nTPM
Skeletal muscle	31.1 nTPM
Endometrium	28.2 nTPM
Esophagus	27.8 nTPM
Heart muscle	26.2 nTPM
Lung	24.9 nTPM
Breast	24.9 nTPM
Placenta	17.0 nTPM

Fibroblasts	7.5 nTPM
Stomach	19.3 nTPM
Skeletal muscle	15.4 nTPM
Lung	13.4 nTPM
Esophagus	9.2 nTPM
Skin	6.3 nTPM
Heart muscle	5.4 nTPM
Adipose tissue	5.2 nTPM
Breast	3.0 nTPM
Prostate	2.9 nTPM
Placenta	2.0 nTPM
Ovary	0.3 nTPM

Intestinal goblet cells	12.1 nTPM
Colon	13.6 nTPM
Small intestine	12.5 nTPM
Rectum	10.1 nTPM

Macrophages	20.9 nTPM
Lung	75.8 nTPM
Prostate	47.0 nTPM
Endometrium	35.2 nTPM
Spleen	24.9 nTPM
Breast	23.1 nTPM
Esophagus	22.0 nTPM
Adipose tissue	18.3 nTPM
Testis	18.0 nTPM
Bone marrow	11.3 nTPM
Kidney	10.6 nTPM
Skeletal muscle	9.6 nTPM
Stomach	8.8 nTPM
Pancreas	7.7 nTPM
Ovary	0.9 nTPM
PBMC	0.0 nTPM

Paneth cells	8.3 nTPM
Colon	19.7 nTPM
Rectum	5.2 nTPM
Small intestine	0.0 nTPM

Plasma cells	4.0 nTPM
Adipose tissue	16.7 nTPM
Stomach	3.1 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	4.5 nTPM
Bronchus	7.4 nTPM
Lung	1.5 nTPM

Smooth muscle cells	3.5 nTPM
Skeletal muscle	10.1 nTPM
Skin	8.4 nTPM
Heart muscle	5.7 nTPM
Endometrium	4.2 nTPM
Breast	3.6 nTPM
Adipose tissue	2.1 nTPM
Prostate	1.9 nTPM
Esophagus	1.5 nTPM
Ovary	1.1 nTPM
Pancreas	0.2 nTPM
Bronchus	0.0 nTPM

T-cells	21.4 nTPM
Lymph node	41.6 nTPM
Colon	39.0 nTPM
Endometrium	38.6 nTPM
Skin	35.9 nTPM
Adipose tissue	28.4 nTPM
Breast	26.8 nTPM
Stomach	26.3 nTPM
Esophagus	26.2 nTPM
Liver	23.2 nTPM
Spleen	15.6 nTPM
Lung	13.6 nTPM
Bone marrow	11.6 nTPM
Ovary	11.1 nTPM
Skeletal muscle	10.5 nTPM
Kidney	8.2 nTPM
PBMC	7.7 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	8.9 nTPM
Skin	8.9 nTPM

Basal prostatic cells	6.9 nTPM
Prostate	6.9 nTPM

Basal respiratory cells	3.2 nTPM
Bronchus	3.2 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Undifferentiated cells	1.1 nTPM
Small intestine	1.9 nTPM
Rectum	1.1 nTPM
Colon	0.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC