Single cell type - TRAPPC10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRAPPC10
Gene descriptionⁱ Full gene name according to HGNC.	Trafficking protein particle complex 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, dendritic cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, dendritic cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRAPPC10 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ABHD17A	Abhydrolase domain containing 17A, depalmitoylase	0.6797	63
OTULIN	OTU deubiquitinase with linear linkage specificity	0.6369	24
CEP78	Centrosomal protein 78	0.6201	63
XCL2	X-C motif chemokine ligand 2	0.6017	63
SAMD3	Sterile alpha motif domain containing 3	0.5974	63
SACM1L	SAC1 like phosphatidylinositide phosphatase	0.5973	24
KIR3DL3	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3	0.5950	63
GNLY	Granulysin	0.5895	63
KLRC4	Killer cell lectin like receptor C4	0.5822	63
CDK13	Cyclin dependent kinase 13	0.5818	52
ABHD17B	Abhydrolase domain containing 17B, depalmitoylase	0.5810	46
ZNF276	Zinc finger protein 276	0.5783	63
OSBPL5	Oxysterol binding protein like 5	0.5759	63
KIR2DL3	Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	0.5731	63
GTF3C1	General transcription factor IIIC subunit 1	0.5638	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.1 nTPM
Breast	19.8 nTPM
Adipose tissue	14.5 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	3.6 nTPM
Lung	3.6 nTPM

Astrocytes	26.1 nTPM
Brain	26.1 nTPM

B-cells	28.9 nTPM
Adipose tissue	56.1 nTPM
Breast	44.1 nTPM
Colon	35.1 nTPM
Kidney	33.4 nTPM
Stomach	30.9 nTPM
Lymph node	22.3 nTPM
Bone marrow	21.3 nTPM
PBMC	17.1 nTPM
Spleen	14.9 nTPM
Liver	13.4 nTPM

Dendritic cells	81.2 nTPM
Adipose tissue	148.0 nTPM
Breast	83.8 nTPM
PBMC	12.0 nTPM

Endothelial cells	10.6 nTPM
Eye	19.4 nTPM
Heart muscle	15.5 nTPM
Skeletal muscle	15.5 nTPM
Endometrium	15.3 nTPM
Skin	14.4 nTPM
Ovary	13.8 nTPM
Testis	11.6 nTPM
Prostate	11.5 nTPM
Breast	11.1 nTPM
Liver	8.2 nTPM
Placenta	5.1 nTPM
Lung	3.1 nTPM
Esophagus	3.1 nTPM
Pancreas	0.0 nTPM

Fibroblasts	9.5 nTPM
Skeletal muscle	16.8 nTPM
Skin	13.1 nTPM
Breast	12.9 nTPM
Prostate	12.7 nTPM
Adipose tissue	12.4 nTPM
Stomach	10.4 nTPM
Ovary	8.5 nTPM
Heart muscle	6.8 nTPM
Lung	6.7 nTPM
Esophagus	2.9 nTPM
Placenta	1.9 nTPM

Intestinal goblet cells	11.0 nTPM
Colon	21.5 nTPM
Rectum	6.7 nTPM
Small intestine	4.9 nTPM

Macrophages	17.6 nTPM
Adipose tissue	35.7 nTPM
Skeletal muscle	34.6 nTPM
Breast	32.9 nTPM
Endometrium	29.8 nTPM
Ovary	23.8 nTPM
Prostate	17.2 nTPM
PBMC	13.6 nTPM
Testis	12.8 nTPM
Spleen	12.5 nTPM
Kidney	12.0 nTPM
Bone marrow	10.0 nTPM
Esophagus	9.4 nTPM
Stomach	8.8 nTPM
Lung	8.5 nTPM
Pancreas	2.5 nTPM

Paneth cells	15.7 nTPM
Colon	36.2 nTPM
Rectum	7.1 nTPM
Small intestine	3.7 nTPM

Plasma cells	28.0 nTPM
Adipose tissue	88.3 nTPM
Spleen	25.3 nTPM
Bone marrow	16.5 nTPM
Stomach	9.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	12.0 nTPM
Bronchus	16.7 nTPM
Lung	7.3 nTPM

Smooth muscle cells	13.1 nTPM
Ovary	20.7 nTPM
Endometrium	19.5 nTPM
Breast	17.4 nTPM
Heart muscle	16.4 nTPM
Adipose tissue	16.1 nTPM
Skeletal muscle	14.9 nTPM
Skin	14.3 nTPM
Prostate	9.1 nTPM
Pancreas	7.9 nTPM
Bronchus	4.8 nTPM
Esophagus	3.1 nTPM

T-cells	37.0 nTPM
Adipose tissue	89.3 nTPM
Endometrium	80.6 nTPM
Skeletal muscle	75.6 nTPM
Breast	59.3 nTPM
Ovary	48.9 nTPM
Colon	45.6 nTPM
Bone marrow	36.6 nTPM
Spleen	32.2 nTPM
Liver	31.7 nTPM
PBMC	30.5 nTPM
Skin	25.4 nTPM
Stomach	23.7 nTPM
Lymph node	21.5 nTPM
Kidney	19.8 nTPM
Prostate	4.7 nTPM
Lung	3.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	16.6 nTPM
Skin	16.6 nTPM

Basal respiratory cells	6.9 nTPM
Bronchus	6.9 nTPM

Basal squamous epithelial cells	4.6 nTPM
Esophagus	4.6 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Undifferentiated cells	11.5 nTPM
Colon	23.5 nTPM
Rectum	6.1 nTPM
Small intestine	4.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC