Single cell type - MCM3AP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MCM3AP
Gene descriptionⁱ Full gene name according to HGNC.	Minichromosome maintenance complex component 3 associated protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MCM3AP is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NHEJ1	Non-homologous end joining factor 1	0.6716	59
MTG1	Mitochondrial ribosome associated GTPase 1	0.6546	59
GET4	Guided entry of tail-anchored proteins factor 4	0.6264	59
DPH1	Diphthamide biosynthesis 1	0.6099	59
HMGN4	High mobility group nucleosomal binding domain 4	0.6065	59
ZNF484	Zinc finger protein 484	0.6055	59
ST20-MTHFS	ST20-MTHFS readthrough	0.6025	59
ZGPAT	Zinc finger CCCH-type and G-patch domain containing	0.6010	59
ABHD18	Abhydrolase domain containing 18	0.5964	59
UTP20	UTP20 small subunit processome component	0.5964	59
RRN3	RRN3 homolog, RNA polymerase I transcription factor	0.5947	59
ERVK3-1	Endogenous retrovirus group K3 member 1	0.5936	59
DIABLO	Diablo IAP-binding mitochondrial protein	0.5897	59
RWDD3	RWD domain containing 3	0.5871	59
RTEL1	Regulator of telomere elongation helicase 1	0.5852	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.3 nTPM
Adipose tissue	18.6 nTPM
Breast	16.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	18.9 nTPM
Lung	18.9 nTPM

Astrocytes	28.1 nTPM
Brain	28.1 nTPM

B-cells	21.3 nTPM
Lymph node	33.2 nTPM
Bone marrow	27.8 nTPM
Spleen	27.3 nTPM
Stomach	27.3 nTPM
Colon	20.8 nTPM
Adipose tissue	18.6 nTPM
Breast	17.3 nTPM
PBMC	15.7 nTPM
Liver	15.1 nTPM
Kidney	9.5 nTPM

Dendritic cells	20.6 nTPM
Adipose tissue	30.9 nTPM
Breast	18.9 nTPM
PBMC	12.0 nTPM

Endothelial cells	14.8 nTPM
Liver	23.8 nTPM
Esophagus	23.6 nTPM
Ovary	20.2 nTPM
Endometrium	20.1 nTPM
Eye	18.6 nTPM
Skeletal muscle	17.2 nTPM
Lung	15.6 nTPM
Testis	14.9 nTPM
Placenta	13.7 nTPM
Breast	11.6 nTPM
Prostate	8.9 nTPM
Pancreas	7.7 nTPM
Skin	6.2 nTPM
Heart muscle	5.3 nTPM

Fibroblasts	12.8 nTPM
Esophagus	20.5 nTPM
Skeletal muscle	18.6 nTPM
Ovary	16.2 nTPM
Lung	13.4 nTPM
Placenta	13.2 nTPM
Adipose tissue	12.6 nTPM
Breast	11.9 nTPM
Prostate	10.1 nTPM
Heart muscle	9.1 nTPM
Skin	7.8 nTPM
Stomach	7.4 nTPM

Intestinal goblet cells	19.2 nTPM
Rectum	25.2 nTPM
Small intestine	18.2 nTPM
Colon	14.3 nTPM

Macrophages	18.6 nTPM
Bone marrow	42.5 nTPM
Esophagus	23.6 nTPM
Pancreas	23.0 nTPM
Spleen	22.8 nTPM
Endometrium	21.2 nTPM
Skeletal muscle	20.0 nTPM
Lung	19.4 nTPM
Adipose tissue	18.2 nTPM
Breast	17.9 nTPM
Stomach	17.6 nTPM
Ovary	17.4 nTPM
Kidney	15.2 nTPM
Testis	13.4 nTPM
Prostate	6.9 nTPM
PBMC	0.0 nTPM

Paneth cells	8.6 nTPM
Rectum	18.3 nTPM
Small intestine	7.5 nTPM
Colon	0.0 nTPM

Plasma cells	21.6 nTPM
Adipose tissue	27.7 nTPM
Spleen	27.5 nTPM
Esophagus	18.4 nTPM
Stomach	17.7 nTPM
Bone marrow	16.5 nTPM

Respiratory ciliated cells	15.5 nTPM
Bronchus	19.4 nTPM
Lung	11.7 nTPM

Smooth muscle cells	12.9 nTPM
Esophagus	24.8 nTPM
Endometrium	22.9 nTPM
Breast	14.5 nTPM
Skeletal muscle	14.0 nTPM
Ovary	13.4 nTPM
Adipose tissue	12.7 nTPM
Pancreas	12.4 nTPM
Skin	9.0 nTPM
Heart muscle	7.3 nTPM
Prostate	5.6 nTPM
Bronchus	4.7 nTPM

T-cells	19.1 nTPM
Lymph node	39.8 nTPM
Bone marrow	38.6 nTPM
Spleen	31.2 nTPM
Stomach	26.4 nTPM
Endometrium	23.0 nTPM
Adipose tissue	22.3 nTPM
Skeletal muscle	21.1 nTPM
Esophagus	19.7 nTPM
Lung	18.2 nTPM
PBMC	17.3 nTPM
Breast	16.3 nTPM
Liver	13.9 nTPM
Skin	10.5 nTPM
Colon	9.0 nTPM
Ovary	8.9 nTPM
Kidney	8.2 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	7.0 nTPM
Skin	7.0 nTPM

Basal prostatic cells	7.1 nTPM
Prostate	7.1 nTPM

Basal squamous epithelial cells	22.2 nTPM
Esophagus	22.2 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Undifferentiated cells	17.9 nTPM
Rectum	19.3 nTPM
Colon	18.8 nTPM
Small intestine	15.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC