Single cell type - PRMT2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRMT2
Gene descriptionⁱ Full gene name according to HGNC.	Protein arginine methyltransferase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (NK-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRMT2 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KLRG1	Killer cell lectin like receptor G1	0.7793	63
UTS2	Urotensin 2	0.7009	63
TSPAN32	Tetraspanin 32	0.6874	63
DENND2D	DENN domain containing 2D	0.6744	63
IFNL1	Interferon lambda 1	0.6727	63
TRGV5	T cell receptor gamma variable 5	0.6653	63
IL12RB1	Interleukin 12 receptor subunit beta 1	0.6591	63
TXK	TXK tyrosine kinase	0.6585	63
KRT73	Keratin 73	0.6500	63
ZAP70	Zeta chain of T cell receptor associated protein kinase 70	0.6482	63
PATL2	PAT1 homolog 2	0.6478	63
TRDC	T cell receptor delta constant	0.6449	63
TMIGD2	Transmembrane and immunoglobulin domain containing 2	0.6422	63
EOMES	Eomesodermin	0.6398	63
CD160	CD160 molecule	0.6379	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	71.5 nTPM
Adipose tissue	72.1 nTPM
Breast	70.9 nTPM

Alveolar cells type 1	93.0 nTPM
Lung	93.0 nTPM

Alveolar cells type 2	36.2 nTPM
Lung	36.2 nTPM

Astrocytes	54.5 nTPM
Brain	54.5 nTPM

B-cells	74.4 nTPM
Colon	111.8 nTPM
PBMC	107.1 nTPM
Adipose tissue	80.2 nTPM
Liver	76.4 nTPM
Stomach	75.9 nTPM
Bone marrow	73.6 nTPM
Lymph node	66.6 nTPM
Breast	65.6 nTPM
Spleen	63.3 nTPM
Kidney	23.8 nTPM

Dendritic cells	192.9 nTPM
Adipose tissue	307.3 nTPM
Breast	140.0 nTPM
PBMC	131.5 nTPM

Endothelial cells	82.9 nTPM
Testis	126.8 nTPM
Breast	113.8 nTPM
Liver	105.5 nTPM
Placenta	100.6 nTPM
Eye	95.5 nTPM
Lung	93.6 nTPM
Prostate	89.0 nTPM
Ovary	78.7 nTPM
Heart muscle	68.6 nTPM
Endometrium	62.5 nTPM
Esophagus	60.9 nTPM
Skeletal muscle	56.2 nTPM
Skin	55.2 nTPM
Pancreas	54.0 nTPM

Fibroblasts	68.0 nTPM
Breast	115.5 nTPM
Esophagus	84.2 nTPM
Placenta	82.7 nTPM
Adipose tissue	74.1 nTPM
Heart muscle	68.2 nTPM
Ovary	58.1 nTPM
Lung	56.9 nTPM
Skin	56.1 nTPM
Stomach	55.0 nTPM
Skeletal muscle	51.7 nTPM
Prostate	45.2 nTPM

Intestinal goblet cells	32.6 nTPM
Small intestine	40.8 nTPM
Colon	32.9 nTPM
Rectum	24.2 nTPM

Macrophages	109.3 nTPM
PBMC	218.3 nTPM
Testis	158.0 nTPM
Pancreas	137.9 nTPM
Adipose tissue	137.9 nTPM
Prostate	121.5 nTPM
Breast	108.6 nTPM
Kidney	108.1 nTPM
Bone marrow	107.5 nTPM
Esophagus	94.5 nTPM
Spleen	85.0 nTPM
Ovary	83.6 nTPM
Endometrium	81.0 nTPM
Lung	80.0 nTPM
Skeletal muscle	68.1 nTPM
Stomach	49.8 nTPM

Paneth cells	40.0 nTPM
Small intestine	41.3 nTPM
Colon	39.6 nTPM
Rectum	39.2 nTPM

Plasma cells	64.6 nTPM
Adipose tissue	141.2 nTPM
Esophagus	55.5 nTPM
Bone marrow	51.1 nTPM
Stomach	40.8 nTPM
Spleen	34.4 nTPM

Respiratory ciliated cells	71.4 nTPM
Lung	81.6 nTPM
Bronchus	61.2 nTPM

Smooth muscle cells	77.2 nTPM
Adipose tissue	108.2 nTPM
Breast	102.4 nTPM
Heart muscle	90.3 nTPM
Ovary	85.9 nTPM
Esophagus	82.2 nTPM
Pancreas	76.5 nTPM
Skeletal muscle	75.5 nTPM
Skin	71.8 nTPM
Prostate	70.6 nTPM
Endometrium	58.6 nTPM
Bronchus	27.0 nTPM

T-cells	167.1 nTPM
PBMC	356.4 nTPM
Bone marrow	287.7 nTPM
Lymph node	217.1 nTPM
Spleen	207.7 nTPM
Adipose tissue	201.1 nTPM
Ovary	200.2 nTPM
Liver	194.4 nTPM
Skeletal muscle	173.1 nTPM
Lung	153.4 nTPM
Stomach	149.1 nTPM
Kidney	141.7 nTPM
Colon	126.9 nTPM
Prostate	108.9 nTPM
Breast	95.2 nTPM
Skin	85.6 nTPM
Endometrium	76.7 nTPM
Esophagus	65.5 nTPM

Basal keratinocytes	46.1 nTPM
Skin	46.1 nTPM

Basal prostatic cells	69.8 nTPM
Prostate	69.8 nTPM

Basal respiratory cells	79.1 nTPM
Bronchus	79.1 nTPM

Cholangiocytes	67.2 nTPM
Liver	67.2 nTPM

Undifferentiated cells	38.3 nTPM
Colon	46.2 nTPM
Small intestine	36.5 nTPM
Rectum	32.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC