Single cell type - TLCD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TLCD1
Gene descriptionⁱ Full gene name according to HGNC.	TLC domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TLCD1 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IRX3	Iroquois homeobox 3	0.5344	35
MUC16	Mucin 16, cell surface associated	0.5153	26
SYNE4	Spectrin repeat containing nuclear envelope family member 4	0.5130	35
PEX13	Peroxisomal biogenesis factor 13	0.5102	26
SLC35A2	Solute carrier family 35 member A2	0.4839	30
SRD5A3	Steroid 5 alpha-reductase 3	0.4719	26
PAPOLA	Poly(A) polymerase alpha	0.4719	10
TMPRSS13	Transmembrane serine protease 13	0.4694	38
IL20RA	Interleukin 20 receptor subunit alpha	0.4667	44
PIGF	Phosphatidylinositol glycan anchor biosynthesis class F	0.4641	26
SLC4A11	Solute carrier family 4 member 11	0.4633	26
GABRP	Gamma-aminobutyric acid type A receptor subunit pi	0.4632	44
AIMP1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1	0.4619	10
EMC6	ER membrane protein complex subunit 6	0.4597	10
UPK1B	Uroplakin 1B	0.4586	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.1 nTPM
Breast	4.0 nTPM
Adipose tissue	0.3 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	8.4 nTPM
Lung	8.4 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	2.5 nTPM
Breast	14.7 nTPM
Kidney	4.8 nTPM
Colon	1.6 nTPM
Liver	1.3 nTPM
Stomach	0.9 nTPM
Spleen	0.7 nTPM
Adipose tissue	0.5 nTPM
PBMC	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM

Dendritic cells	1.0 nTPM
Breast	2.5 nTPM
Adipose tissue	0.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	1.7 nTPM
Breast	4.9 nTPM
Prostate	3.5 nTPM
Skin	3.1 nTPM
Endometrium	1.9 nTPM
Liver	1.8 nTPM
Placenta	1.7 nTPM
Eye	1.6 nTPM
Skeletal muscle	1.4 nTPM
Testis	1.1 nTPM
Ovary	1.0 nTPM
Esophagus	1.0 nTPM
Heart muscle	0.2 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	4.2 nTPM
Prostate	13.9 nTPM
Heart muscle	7.4 nTPM
Breast	4.9 nTPM
Lung	4.5 nTPM
Placenta	3.8 nTPM
Skin	3.6 nTPM
Skeletal muscle	2.4 nTPM
Ovary	1.8 nTPM
Stomach	1.5 nTPM
Esophagus	1.2 nTPM
Adipose tissue	1.1 nTPM

Intestinal goblet cells	8.8 nTPM
Colon	12.9 nTPM
Small intestine	7.5 nTPM
Rectum	6.0 nTPM

Macrophages	1.5 nTPM
Breast	5.5 nTPM
Endometrium	3.4 nTPM
Adipose tissue	2.6 nTPM
Pancreas	2.5 nTPM
Kidney	2.3 nTPM
Prostate	2.2 nTPM
Skeletal muscle	1.6 nTPM
Testis	1.2 nTPM
Lung	1.1 nTPM
Ovary	0.8 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	4.5 nTPM
Rectum	10.3 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	1.8 nTPM
Esophagus	6.1 nTPM
Stomach	1.5 nTPM
Spleen	0.7 nTPM
Adipose tissue	0.6 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	31.0 nTPM
Bronchus	45.9 nTPM
Lung	16.0 nTPM

Smooth muscle cells	8.8 nTPM
Bronchus	71.8 nTPM
Pancreas	5.2 nTPM
Breast	5.1 nTPM
Heart muscle	2.8 nTPM
Prostate	2.5 nTPM
Endometrium	2.5 nTPM
Skeletal muscle	2.5 nTPM
Adipose tissue	1.8 nTPM
Ovary	1.7 nTPM
Skin	1.4 nTPM
Esophagus	0.0 nTPM

T-cells	2.2 nTPM
Breast	10.5 nTPM
Endometrium	7.1 nTPM
Colon	4.7 nTPM
Liver	3.3 nTPM
Skin	3.3 nTPM
Kidney	2.0 nTPM
Adipose tissue	1.8 nTPM
Lung	1.5 nTPM
Skeletal muscle	1.0 nTPM
Stomach	0.6 nTPM
Spleen	0.3 nTPM
PBMC	0.2 nTPM
Bone marrow	0.1 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM

Basal prostatic cells	11.8 nTPM
Prostate	11.8 nTPM

Basal respiratory cells	23.9 nTPM
Bronchus	23.9 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Cytotrophoblasts	18.3 nTPM
Placenta	18.3 nTPM

Undifferentiated cells	8.0 nTPM
Rectum	10.2 nTPM
Colon	7.3 nTPM
Small intestine	6.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC