Single cell type - GBP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GBP2
Gene descriptionⁱ Full gene name according to HGNC.	Guanylate binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Glandular and luminal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, EFO-21, HDLM-2, HUVEC TERT2, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Glandular and luminal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GBP2 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRKX	Protein kinase X-linked	0.6296	44
MAFF	MAF bZIP transcription factor F	0.5819	44
ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3	0.5559	44
CRISP3	Cysteine rich secretory protein 3	0.5474	44
SCGB1D2	Secretoglobin family 1D member 2	0.5386	44
PIGA	Phosphatidylinositol glycan anchor biosynthesis class A	0.5366	41
AC005551.1	Novel protein	0.5345	44
SCGB2A1	Secretoglobin family 2A member 1	0.5322	44
HAP1	Huntingtin associated protein 1	0.5315	44
YTHDC1	YTH domain containing 1	0.5253	44
PNPLA8	Patatin like phospholipase domain containing 8	0.5231	41
TNFAIP3	TNF alpha induced protein 3	0.5219	41
ZNF611	Zinc finger protein 611	0.5180	44
CDSN	Corneodesmosin	0.5120	44
TMEM101	Transmembrane protein 101	0.5097	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	35.4 nTPM
Adipose tissue	38.7 nTPM
Breast	32.2 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	34.3 nTPM
Lung	34.3 nTPM

Astrocytes	0.7 nTPM
Brain	0.7 nTPM

B-cells	21.5 nTPM
Colon	67.1 nTPM
Adipose tissue	38.1 nTPM
PBMC	22.8 nTPM
Bone marrow	18.8 nTPM
Spleen	18.3 nTPM
Stomach	14.5 nTPM
Lymph node	13.1 nTPM
Kidney	9.5 nTPM
Breast	8.1 nTPM
Liver	4.6 nTPM

Dendritic cells	47.7 nTPM
Adipose tissue	86.7 nTPM
Breast	52.5 nTPM
PBMC	4.0 nTPM

Endothelial cells	60.5 nTPM
Skin	147.1 nTPM
Prostate	115.6 nTPM
Pancreas	108.1 nTPM
Eye	74.4 nTPM
Esophagus	64.2 nTPM
Testis	59.5 nTPM
Skeletal muscle	58.9 nTPM
Lung	49.9 nTPM
Heart muscle	49.4 nTPM
Breast	44.2 nTPM
Endometrium	25.2 nTPM
Ovary	22.8 nTPM
Placenta	22.1 nTPM
Liver	5.5 nTPM

Fibroblasts	41.2 nTPM
Prostate	83.5 nTPM
Esophagus	60.2 nTPM
Heart muscle	54.7 nTPM
Stomach	47.5 nTPM
Skeletal muscle	45.4 nTPM
Adipose tissue	44.4 nTPM
Lung	33.5 nTPM
Skin	32.7 nTPM
Breast	27.3 nTPM
Ovary	18.1 nTPM
Placenta	6.2 nTPM

Intestinal goblet cells	15.7 nTPM
Small intestine	24.0 nTPM
Colon	13.6 nTPM
Rectum	9.6 nTPM

Macrophages	81.1 nTPM
Spleen	187.7 nTPM
Prostate	177.6 nTPM
Lung	133.4 nTPM
Adipose tissue	101.0 nTPM
Kidney	99.1 nTPM
Testis	98.2 nTPM
Bone marrow	85.0 nTPM
Stomach	76.2 nTPM
Esophagus	62.9 nTPM
Skeletal muscle	59.1 nTPM
Endometrium	50.5 nTPM
Breast	46.0 nTPM
Ovary	24.0 nTPM
Pancreas	15.3 nTPM
PBMC	0.0 nTPM

Paneth cells	25.9 nTPM
Colon	36.2 nTPM
Small intestine	30.0 nTPM
Rectum	11.6 nTPM

Plasma cells	17.3 nTPM
Adipose tissue	50.3 nTPM
Esophagus	18.4 nTPM
Stomach	10.8 nTPM
Bone marrow	5.0 nTPM
Spleen	1.9 nTPM

Respiratory ciliated cells	27.5 nTPM
Bronchus	28.7 nTPM
Lung	26.2 nTPM

Smooth muscle cells	45.2 nTPM
Prostate	88.7 nTPM
Heart muscle	76.6 nTPM
Skin	67.7 nTPM
Esophagus	60.4 nTPM
Endometrium	49.7 nTPM
Breast	46.8 nTPM
Skeletal muscle	31.0 nTPM
Adipose tissue	25.1 nTPM
Ovary	23.9 nTPM
Pancreas	15.7 nTPM
Bronchus	11.2 nTPM

T-cells	81.8 nTPM
Colon	139.3 nTPM
PBMC	122.3 nTPM
Adipose tissue	119.0 nTPM
Kidney	106.7 nTPM
Prostate	94.7 nTPM
Liver	93.1 nTPM
Ovary	86.7 nTPM
Lung	83.6 nTPM
Bone marrow	77.5 nTPM
Spleen	76.1 nTPM
Lymph node	67.3 nTPM
Skin	65.8 nTPM
Skeletal muscle	65.1 nTPM
Endometrium	58.1 nTPM
Stomach	52.1 nTPM
Breast	43.3 nTPM
Esophagus	39.3 nTPM

Basal keratinocytes	46.5 nTPM
Skin	46.5 nTPM

Basal prostatic cells	123.5 nTPM
Prostate	123.5 nTPM

Basal respiratory cells	24.9 nTPM
Bronchus	24.9 nTPM

Basal squamous epithelial cells	18.2 nTPM
Esophagus	18.2 nTPM

Undifferentiated cells	15.3 nTPM
Small intestine	22.1 nTPM
Colon	16.7 nTPM
Rectum	6.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC